Full length alpha1 Glycine receptor in presence of 32uM Tetrahydrocannabinol
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 7m6m
Q-score: 0.46
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- (6ar,10ar)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6h-benzo[c]chromen-1-ol (314 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 0.1mM Glycine
Resolution: 2.61 Å
EM Method: Single-particle
Fitted PDBs: 7m6n
Q-score: 0.508
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 0.1mM Glycine and 32uM Tetrahydrocannabinol
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 7m6o
Q-score: 0.481
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (6ar,10ar)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6h-benzo[c]chromen-1-ol (314 Da, Ligand)
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 1mM Glycine
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 7m6p
Q-score: 0.424
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 1
Resolution: 2.91 Å
EM Method: Single-particle
Fitted PDBs: 7m6q
Q-score: 0.486
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (6ar,10ar)-6,6,9-trimethyl-3-pentyl-6a,7,8,10a-tetrahydro-6h-benzo[c]chromen-1-ol (314 Da, Ligand)
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 2
Resolution: 3.57 Å
EM Method: Single-particle
Fitted PDBs: 7m6r
Q-score: 0.369
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Full length alpha1 Glycine receptor in presence of 1mM Glycine and 32uM Tetrahydrocannabinol State 3
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 7m6s
Q-score: 0.355
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S
Nat Commun (2022) 13 pp. 4862-4862 [ Pubmed: 35982060 DOI: doi:10.1038/s41467-022-32594-5 ]
- Glycine receptor subunit alpha z1 (250 MDa, Complex from Danio rerio)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycine (75 Da, Ligand)
- Glycine receptor subunit alphaz1 (50 kDa, Protein from Danio rerio)
Structure of canine Sec61 inhibited by mycolactone
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 6z3t
Q-score: 0.341
Gerard SF, Hall BS, Zaki AM, Corfield KA, Mayerhofer PU, Costa C, Whelligan DK, Biggin PC, Simmonds RE, Higgins MK
Mol Cell (2020) 79 pp. 406-415.e7 [ DOI: doi:10.1016/j.molcel.2020.06.013 Pubmed: 32692975 ]
- Protein transport protein sec61 subunit beta (1 kDa, Protein from Canis lupus familiaris)
- Ribosome-translocon complexes from canine er microsomes, bound to mycolactone (Complex from Canis lupus familiaris)
- Protein transport protein sec61 subunit alpha isoform 1 (52 kDa, Protein from Canis lupus familiaris)
- [(6~{s},7~{s},9~{z},12~{r})-12-[(~{z},2~{s},6~{r},7~{r},9~{r})-4,6-dimethyl-7,9-bis(oxidanyl)dec-4-en-2-yl]-7,9-dimethyl-2-oxidanylidene-1-oxacyclododec-9-en-6-yl] (2~{e},4~{e},6~{e},8~{e},10~{e},12~{s},13~{s},15~{s})-4,6,10-trimethyl-12,13,15-tris(oxidanyl)hexadeca-2,4,6,8,10-pentaenoate (743 Da, Ligand)
- Protein transport protein sec61 subunit gamma (7 kDa, Protein from Canis lupus familiaris)