Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the absence of telomeric ssDNA
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8soj
Q-score: 0.34
Cai SW, Takai H, Zaug AJ, Dilgen TC, Cech TR, Walz T, de Lange T
Cell (2024) 187 pp. 3638-3651.e18 [ Pubmed: 38838667 DOI: doi:10.1016/j.cell.2024.05.002 ]
- Cst complex subunit stn1 (115 kDa, Protein from Homo sapiens)
- Protection of telomeres protein 1 (72 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cst complex subunit ctc1 (178 kDa, Protein from Homo sapiens)
- Cst complex subunit ten1 (13 kDa, Protein from Homo sapiens)
- Human cst-pot1(esdl)/tpp1 complex (380 kDa, Complex from Homo sapiens)
Cryo-EM structure of human CST bound to POT1(ESDL)/TPP1 in the presence of telomeric ssDNA
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8sok
Q-score: 0.283
Cai SW, Takai H, Zaug AJ, Dilgen TC, Cech TR, Walz T, de Lange T
Cell (2024) 187 pp. 3638-3651.e18 [ Pubmed: 38838667 DOI: doi:10.1016/j.cell.2024.05.002 ]
- Ssdna-bound human cst-pot1(esdl)/tpp1 complex (370 kDa, Complex from Homo sapiens)
- Cst complex subunit stn1 (42 kDa, Protein from Homo sapiens)
- Protection of telomeres protein 1 (72 kDa, Protein from Homo sapiens)
- Tpp1 (58 kDa, Protein from Homo sapiens)
- Dna (5'-d(*tp*tp*ap*gp*gp*gp*tp*tp*ap*g)-3') (5 kDa, DNA from synthetic construct)
- Zinc ion (65 Da, Ligand)
- Cst complex subunit ctc1 (178 kDa, Protein from Homo sapiens)
- Cst complex subunit ten1 (13 kDa, Protein from Homo sapiens)
The structure of human CST reveals a decameric assembly bound to telomeric DNA
Lim C, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR
Science (2020) 368 pp. 1081-1085 [ DOI: 10.1126/science.aaz9649 Pubmed: 32499435 ]
Image sets:
The structure of human CST reveals a decameric assembly bound to telomeric DNA
Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR
Science (2020) 368 pp. 1081-1085 [ Pubmed: 32499435 DOI: doi:10.1126/science.aaz9649 ]
- 3xtel (DNA from Homo sapiens)
- Homo sapiens cst complex subunit ctc1 (Protein from Homo sapiens)
- Homo sapiens cst complex subunit stn1 (Protein from Homo sapiens)
- Homo sapiens cst complex subunit ten1 (Protein from Homo sapiens)
- Decameric assembly of human cst complex with telomeric single-stranded dna (2 MDa, Complex from Homo sapiens)
Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR
Science (2020) 368 pp. 1081-1085 [ Pubmed: 32499435 DOI: doi:10.1126/science.aaz9649 ]
- Homo sapien stn1 (Protein from Homo sapiens)
- Heterotrimeric complex of human cst complex without dna (200 kDa, Complex from Homo sapiens)
- Homo sapien ten1 (Protein from Homo sapiens)
- Homo sapien ctc1 (Protein from Homo sapiens)
Arm conformation from CST-3xTEL oligomer-mixture
Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR
Science (2020) 368 pp. 1081-1085 [ Pubmed: 32499435 DOI: doi:10.1126/science.aaz9649 ]
Head conformation from CST-3xTEL oligomer-mixture
Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR
Science (2020) 368 pp. 1081-1085 [ Pubmed: 32499435 DOI: doi:10.1126/science.aaz9649 ]
Cryo-EM structure of CST bound to telomeric single-stranded DNA
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6w6w
Q-score: 0.536
Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR
Science (2020) 368 pp. 1081-1085 [ Pubmed: 32499435 DOI: doi:10.1126/science.aaz9649 ]
- Cst complex subunit ctc1 (136 kDa, Protein from Homo sapiens)
- Dna (5'-d(p*tp*ap*gp*g)-3') (1 kDa, DNA from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Human cst complex (200 kDa, Complex from Homo sapiens)
- Cst complex subunit stn1 (43 kDa, Protein from Homo sapiens)
- Cst complex subunit ten1 (17 kDa, Protein from Homo sapiens)