Vaccine-elicited human antibody 2C06 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8g4m
Q-score: 0.564
Wang S, Matassoli F, Zhang B, Liu T, Shen CH, Bylund T, Johnston T, Henry AR, Teng IT, Tripathi P, Becker JE, Changela A, Chaudhary R, Cheng C, Gaudinski M, Gorman J, Harris DR, Lee M, Morano NC, Novik L, O'Dell S, Olia AS, Parchment DK, Rawi R, Roberts-Torres J, Stephens T, Tsybovsky Y, Wang D, Van Wazer DJ, Zhou T, Doria-Rose NA, Koup RA, Shapiro L, Douek DC, McDermott AB, Kwong PD
Cell Rep (2023) 42 pp. 112755-112755 [ DOI: doi:10.1016/j.celrep.2023.112755 Pubmed: 37436899 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Antibody light chain (23 kDa, Protein from Homo sapiens)
- Antibody heavy chain (25 kDa, Protein from Homo sapiens)
- Hiv envelope trimer in complex with three copies of antibody fab (Complex)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Vaccine-elicited human antibody 2C09 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8g4t
Q-score: 0.56
Wang S, Matassoli F, Zhang B, Liu T, Shen CH, Bylund T, Johnston T, Henry AR, Teng IT, Tripathi P, Becker JE, Changela A, Chaudhary R, Cheng C, Gaudinski M, Gorman J, Harris DR, Lee M, Morano NC, Novik L, O'Dell S, Olia AS, Parchment DK, Rawi R, Roberts-Torres J, Stephens T, Tsybovsky Y, Wang D, Van Wazer DJ, Zhou T, Doria-Rose NA, Koup RA, Shapiro L, Douek DC, McDermott AB, Kwong PD
Cell Rep (2023) 42 pp. 112755-112755 [ DOI: doi:10.1016/j.celrep.2023.112755 Pubmed: 37436899 ]
- Fab 2c09 light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab 2c09 heavy chain (24 kDa, Protein from Homo sapiens)
- Hiv envelope trimer in complex with three copies of antibody fab (Complex)
- Envelope glycoprotein bg505 ds-sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein bg505 ds-sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of SIVmac239 SOS-2P Env trimer in complex with human bNAb PGT145
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 8dvd
Q-score: 0.322
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]
- Sivmac239 sos-2p in complex with pgt145 (Complex from Simian immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt145 heavy (26 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (57 kDa, Protein from Simian immunodeficiency virus)
- Pgt145 light (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (16 kDa, Protein from Simian immunodeficiency virus)
- Alpha-d-mannopyranose (180 Da, Ligand)
SIV E660.CR54 SOS-2P Env Trimer with ITS92.02
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 8dua
Q-score: 0.249
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (16 kDa, Protein from Simian immunodeficiency virus)
- Envelope glycoprotein gp120 (59 kDa, Protein from Simian immunodeficiency virus)
- Siv e660.cr54 sos-2p with its92.02 (Complex from Influenza A virus)
- Its92.02 light chain (23 kDa, Protein from Macaca mulatta)
- Its92.02 heavy chain (24 kDa, Protein from Macaca mulatta)
In-situ structure of SIV trimer
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]
in situ SIVmac239-Env trimers on the surface of AT-2-inactivated virions
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]
in situ SIVmac239-Env trimers on the surface of AT-2-inactivated virions
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]
In-situ structure of SIVmac239-Env trimers with ITS90.03 associated
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]
SIV mac239 SOS-2P K169T Env trimer with bNAb PGT145 and jacalin
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 7ly9
Q-score: 0.377
Lee M, Changela A, Gorman J, Rawi R, Bylund T, Chao CW, Lin BC, Louder MK, Olia AS, Zhang B, Doria-Rose NA, Zolla-Pazner S, Shapiro L, Chuang GY, Kwong PD
Nat Commun (2021) 12 pp. 6470-6470 [ DOI: doi:10.1038/s41467-021-26579-z Pubmed: 34753907 ]
- 2909 heavy chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- 2909 light chain (22 kDa, Protein from Homo sapiens)
- 2909 fab in complex with 3bnc117 fab and cap256.wk34.c80 sosip.rns2 n160k hiv-1 env trimer (Complex from Human immunodeficiency virus 1)
- 3bnc117 light chain (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 3bnc117 heavy chain (24 kDa, Protein from Homo sapiens)