Antibody vFP53.02 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8fr6
Q-score: 0.528
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- Antibody fab (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Complex of antibody fab vfp53.02 with hiv-1 env trimer bg505 ds-sosip (Complex)
- Vfp53.02 fab heavy chain (24 kDa, Protein from Mus musculus)
- Hiv-1 env trimer bg505 ds-sosip (Complex from Human immunodeficiency virus 1)
- Vfp53.02 fab light chain (24 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
vFP52.02 Fab in complex with BG505 DS-SOSIP Env trimer
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 8g85
Q-score: 0.323
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp52.02 heavy (13 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vfp52.02 light (11 kDa, Protein from Mus musculus)
- Vfp52.02 fab in complex with bg505 ds-sosip env trimer (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 1)
Resolution: 4.66 Å
EM Method: Single-particle
Fitted PDBs: 8g9w
Q-score: 0.237
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp49.02 light chain (23 kDa, Protein from Mus musculus)
- Vfp49.02 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Vfp49.02 heavy chain (25 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2)
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 8g9x
Q-score: 0.253
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp49.02 light chain (23 kDa, Protein from Mus musculus)
- Vfp49.02 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Vfp49.02 heavy chain (25 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 3)
Resolution: 4.28 Å
EM Method: Single-particle
Fitted PDBs: 8g9y
Q-score: 0.291
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp49.02 light chain (23 kDa, Protein from Mus musculus)
- Vfp49.02 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Vfp49.02 heavy chain (25 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer
Resolution: 4.04 Å
EM Method: Single-particle
Fitted PDBs: 8gas
Q-score: 0.347
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp48.02 heavy chain (13 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vfp48.02 light chain (12 kDa, Protein from Mus musculus)
- Vfp48.02 fab in complex with bg505 ds-sosip env trimer (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of SIVmac239 SOS-2P Env trimer in complex with human bNAb PGT145
Resolution: 4.12 Å
EM Method: Single-particle
Fitted PDBs: 8dvd
Q-score: 0.322
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]
- Sivmac239 sos-2p in complex with pgt145 (Complex from Simian immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt145 heavy (26 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (57 kDa, Protein from Simian immunodeficiency virus)
- Pgt145 light (23 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (16 kDa, Protein from Simian immunodeficiency virus)
- Alpha-d-mannopyranose (180 Da, Ligand)
SIV E660.CR54 SOS-2P Env Trimer with ITS92.02
Resolution: 4.32 Å
EM Method: Single-particle
Fitted PDBs: 8dua
Q-score: 0.249
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (16 kDa, Protein from Simian immunodeficiency virus)
- Envelope glycoprotein gp120 (59 kDa, Protein from Simian immunodeficiency virus)
- Siv e660.cr54 sos-2p with its92.02 (Complex from Influenza A virus)
- Its92.02 light chain (23 kDa, Protein from Macaca mulatta)
- Its92.02 heavy chain (24 kDa, Protein from Macaca mulatta)
In-situ structure of SIV trimer
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]
in situ SIVmac239-Env trimers on the surface of AT-2-inactivated virions
Gorman J, Wang C, Mason RD, Nazzari AF, Welles HC, Zhou T, Bess Jr JW, Bylund T, Lee M, Tsybovsky Y, Verardi R, Wang S, Yang Y, Zhang B, Rawi R, Keele BF, Lifson JD, Liu J, Roederer M, Kwong PD
Nat Struct Mol Biol (2022) 29 pp. 1080-1091 [ DOI: doi:10.1038/s41594-022-00852-1 Pubmed: 36344847 ]