Cryo-EM structure of Mycobacterium tuberculosis DppABCD in apo form
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8wd9
Q-score: 0.528
To Be Published
- Probable periplasmic dipeptide-binding lipoprotein dppa (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Probable dipeptide-transport integral membrane protein abc transporter dppb (32 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Palmitic acid (256 Da, Ligand)
- (2s)-1-(hexadecanoyloxy)propan-2-yl (10s)-10-methyloctadecanoate (594 Da, Ligand)
- Probable dipeptide-transport integral membrane protein abc transporter dppc (30 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Dppabcd (Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Probable dipeptide-transport atp-binding protein abc transporter dppd (59 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
Cryo-EM structure of the substrate-bound DppABCD complex
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8wda
Q-score: 0.545
To Be Published
- Probable periplasmic dipeptide-binding lipoprotein dppa (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Probable dipeptide-transport integral membrane protein abc transporter dppb (32 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Palmitic acid (256 Da, Ligand)
- (2s)-1-(hexadecanoyloxy)propan-2-yl (10s)-10-methyloctadecanoate (594 Da, Ligand)
- Probable dipeptide-transport integral membrane protein abc transporter dppc (30 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Dppabcd (Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Probable dipeptide-transport atp-binding protein abc transporter dppd (59 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Tetrapeptide (330 Da, Protein from Mycolicibacterium smegmatis MC2 155)
Cryo-EM structure of the ATP-bound DppABCD complex
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8wdb
Q-score: 0.605
To Be Published
- Probable periplasmic dipeptide-binding lipoprotein dppa (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Probable dipeptide-transport integral membrane protein abc transporter dppb (32 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Probable dipeptide-transport atp-binding protein abc transporter dppd (59 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Probable dipeptide-transport integral membrane protein abc transporter dppc (30 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Dppabcd (Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of the ATP-bound Mtb DppABCD with the D445A mutation of DppA
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 8xfc
Q-score: 0.425
To Be Published
- Probable dipeptide-transport integral membrane protein abc transporter dppb (32 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Probable dipeptide-transport atp-binding protein abc transporter dppd (59 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Dppabcd (Complex from Mycobacterium tuberculosis H37Rv)
- Probable dipeptide-transport integral membrane protein abc transporter dppc (30 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Probable periplasmic dipeptide-binding lipoprotein dppa (56 kDa, Protein from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- Adenosine-5'-triphosphate (507 Da, Ligand)
Cryo-EM structure of Mycobacterium tuberculosis irtAB complexed with ATP in an occluded conformation
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 7wiw
Q-score: 0.56
Sun S, Gao Y, Yang X, Yang X, Hu T, Liang J, Xiong Z, Ran Y, Ren P, Bai F, Guddat LW, Yang H, Rao Z, Zhang B
Protein Cell (2023) 14 pp. 448-458 [ Pubmed: 36882106 DOI: doi:10.1093/procel/pwac060 ]
- Mycobactin import atp-binding/permease protein irtb (61 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Mycobactin import atp-binding/permease protein irta (93 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- Irtab (Complex from Mycobacterium tuberculosis H37Rv)
Cryo-EM structure of Mycobacterium tuberculosis irtAB in complex with ADP
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 7wix
Q-score: 0.48
Sun S, Gao Y, Yang X, Yang X, Hu T, Liang J, Xiong Z, Ran Y, Ren P, Bai F, Guddat LW, Yang H, Rao Z, Zhang B
Protein Cell (2023) 14 pp. 448-458 [ Pubmed: 36882106 DOI: doi:10.1093/procel/pwac060 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Mycobactin import atp-binding/permease protein irta (93 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- Mycobactin import atp-binding/permease protein irtb (61 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- Magnesium ion (24 Da, Ligand)
- Irtab (Complex from Mycobacterium tuberculosis H37Rv)
Mycobacterium smegmatis LpqY-SugABC complex in the catalytic intermediate state
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 7cag
Q-score: 0.453
Liu F, Liang J, Zhang B, Gao Y, Yang X, Hu T, Yang H, Xu W, Guddat LW, Rao Z
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abb9833 Pubmed: 33127676 ]
- Mycobacterium smegmatis lpqy-sugabc complex in the catalytic intermediate state (Complex from Mycolicibacterium smegmatis MC2 155)
- Abc sugar transporter, permease component (32 kDa, Protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155))
- Abc transporter, atp-binding protein sugc (43 kDa, Protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155))
- Bacterial extracellular solute-binding protein (50 kDa, Protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155))
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Abc transporter, permease protein sugb (29 kDa, Protein from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155))
SARS-Cov-2 RNA-dependent RNA polymerase in complex with cofactors in reduced conditions
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 7btf
Q-score: 0.569
Gao Y, Yan L, Huang Y, Liu F, Zhao Y, Cao L, Wang T, Sun Q, Ming Z, Zhang L, Ge J, Zheng L, Zhang Y, Wang H, Zhu Y, Zhu C, Hu T, Hua T, Zhang B, Yang X, Li J, Yang H, Liu Z, Xu W, Guddat LW, Wang Q, Lou Z, Rao Z
Science (2020) 368 pp. 779-782 [ Pubmed: 32277040 DOI: doi:10.1126/science.abb7498 ]
- Zinc ion (65 Da, Ligand)
- Rna-directed rna polymerase (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (9 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 8 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Structure of sars-cov-2 rna-dependent rna polymerase in complex with cofactors in reduced condition (155 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)