5-HT1A-Gi in complex with compound (R)-IHCH-7179
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8jt6
Q-score: 0.542
Chen Z, Yu J, Wang H, Xu P, Fan L, Sun F, Huang S, Zhang P, Huang H, Gu S, Zhang B, Zhou Y, Wan X, Pei G, Xu HE, Cheng J, Wang S
Cell (2024) 187 pp. 2194-2208.e22 [ Pubmed: 38552625 DOI: doi:10.1016/j.cell.2024.02.034 ]
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Soluble cytochrome b562,5-hydroxytryptamine receptor 1a (60 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- [(2r)-1-[oxidanyl-[(2r,3r,5s,6r)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl] (5e,8e)-hexadeca-5,8,11,14-tetraenoate (854 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- 1-(4-fluorophenyl)-4-[(7r)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one (377 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
- 5-ht1a-gi in complex with compound (r)-ihch-7179 (Complex from Homo sapiens)
Cryo-EM structure of human HCAR2-Gi complex with niacin
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8ija
Q-score: 0.574
Pan X, Ye F, Ning P, Zhang Z, Li X, Zhang B, Wang Q, Chen G, Gao W, Qiu C, Wu Z, Li J, Zhu L, Xia J, Gong K, Du Y
Cell Discov (2023) 9 pp. 118-118 [ DOI: doi:10.1038/s41421-023-00610-7 Pubmed: 38012147 ]
- Hydroxycarboxylic acid receptor 2 (34 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of human hcar2-gi complex with niacin (Complex from Homo sapiens)
- Scfv16 (26 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7y04
Q-score: 0.49
Wen Z, Zhang Y, Zhang B, Hang Y, Xu L, Chen Y, Xie Q, Zhao Q, Zhang L, Li G, Zhao B, Sun F, Zhai Y, Zhu Y
Structure (2023) 31 pp. 295- [ Pubmed: 36649707 DOI: doi:10.1016/j.str.2022.12.013 ]
- Aryl hydrocarbon receptor (46 kDa, Protein from Mus musculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Hsp90-ahr-p23 complex (Complex from Mus musculus)
- Prostaglandin e synthase 3 (Complex from Mus musculus)
- Prostaglandin e synthase 3 (20 kDa, Protein from Mus musculus)
- Heat shock protein hsp 90-beta (Complex from Mus musculus)
- Beryllium trifluoride ion (66 Da, Ligand)
- Heat shock protein hsp 90-beta (86 kDa, Protein from Mus musculus)
- Aryl hydrocarbon receptor (Complex)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8h77
Q-score: 0.45
Wen Z, Zhang Y, Zhang B, Hang Y, Xu L, Chen Y, Xie Q, Zhao Q, Zhang L, Li G, Zhao B, Sun F, Zhai Y, Zhu Y
Structure (2023) 31 pp. 295- [ Pubmed: 36649707 DOI: doi:10.1016/j.str.2022.12.013 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Ah receptor-interacting protein (Complex from Mus musculus)
- Prostaglandin e synthase 3 (Complex from Mus musculus)
- Ah receptor-interacting protein (38 kDa, Protein from Mus musculus)
- Prostaglandin e synthase 3 (20 kDa, Protein from Mus musculus)
- Heat shock protein hsp 90-beta (Complex from Mus musculus)
- Aryl hydrocarbon receptor (Complex from Mus musculus)
- Mouse hsp90-ahr-p23-xap2 complex (Complex)
- Beryllium trifluoride ion (66 Da, Ligand)
- Aryl hydrocarbon receptor (50 kDa, Protein from Mus musculus)
- Heat shock protein hsp 90-beta (86 kDa, Protein from Mus musculus)
ACE2 -Targeting Monoclonal Antibody as Potent and Broad-Spectrum Coronavirus Blocker
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7v61
Q-score: 0.366
Chen Y, Zhang YN, Yan R, Wang G, Zhang Y, Zhang ZR, Li Y, Ou J, Chu W, Liang Z, Wang Y, Chen YL, Chen G, Wang Q, Zhou Q, Zhang B, Wang C
Signal Transduct Target Ther (2021) 6 pp. 315-315 [ Pubmed: 34433803 DOI: doi:10.1038/s41392-021-00740-y ]
- 3e8 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Ace2-b0at1 complex (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Sodium-dependent neutral amino acid transporter b(0)at1 (73 kDa, Protein from Homo sapiens)
- 3e8 (49 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
S protein of SARS-CoV-2 in complex with 2G1
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7x08
Q-score: 0.458
Ma H, Guo Y, Tang H, Tseng CK, Wang L, Zong H, Wang Z, He Y, Chang Y, Wang S, Huang H, Ke Y, Yuan Y, Wu M, Zhang Y, Drelich A, Kempaiah KR, Peng BH, Wang A, Yang K, Yin H, Liu J, Yue Y, Xu W, Zhu S, Ji T, Zhang X, Wang Z, Li G, Liu G, Song J, Mu L, Xiang Z, Song Z, Chen H, Bian Y, Zhang B, Chen H, Zhang J, Liao Y, Zhang L, Yang L, Chen Y, Gilly J, Xiao X, Han L, Jiang H, Xie Y, Zhou Q, Zhu J
Cell Discov (2022) 8 pp. 16-16 [ DOI: doi:10.1038/s41421-022-00381-7 Pubmed: 35169121 ]
- S protein of sars-cov-2 in complex with 2g1 (Complex)
- Light chain of 2g1 (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of 2g1 (49 kDa, Protein from Homo sapiens)
- 2g1 (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Linoleic acid (280 Da, Ligand)
- S protein of sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus)
Structure of SARS-CoV-2 spike at pH 4.5
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7jwy
Q-score: 0.612
Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schon A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, Stephens T, Stuckey J, Teng IT, Wang P, Wang S, Zhang B, Friesner RA, Ho DD, Mascola JR, Shapiro L, Kwong PD
Cell Host Microbe (2020) 28 pp. 867-879.e5 [ DOI: doi:10.1016/j.chom.2020.11.004 Pubmed: 33271067 ]
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike at ph 4.5 (423 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
Structure of SARS-CoV-2 spike at pH 4.0
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 6xlu
Q-score: 0.63
Zhou T, Tsybovsky Y, Gorman J, Rapp M, Cerutti G, Chuang GY, Katsamba PS, Sampson JM, Schon A, Bimela J, Boyington JC, Nazzari A, Olia AS, Shi W, Sastry M, Stephens T, Stuckey J, Teng IT, Wang P, Wang S, Zhang B, Friesner RA, Ho DD, Mascola JR, Shapiro L, Kwong PD
Cell Host Microbe (2020) 28 pp. 867-879.e5 [ DOI: doi:10.1016/j.chom.2020.11.004 Pubmed: 33271067 ]
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Sars-cov-2 spike (423 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)