Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8tg9
Q-score: 0.495
Dunn ME, Kithcart A, Kim JH, Ho AJ, Franklin MC, Romero Hernandez A, de Hoon J, Botermans W, Meyer J, Jin X, Zhang D, Torello J, Jasewicz D, Kamat V, Garnova E, Liu N, Rosconi M, Pan H, Karnik S, Burczynski ME, Zheng W, Rafique A, Nielsen JB, De T, Verweij N, Pandit A, Locke A, Chalasani N, Melander O, Schwantes-An TH, Baras A, Lotta LA, Musser BJ, Mastaitis J, Devalaraja-Narashimha KB, Rankin AJ, Huang T, Herman G, Olson W, Murphy AJ, Yancopoulos GD, Olenchock BA, Morton L
Nature (2024) 633 pp. 654-661 [ DOI: doi:10.1038/s41586-024-07903-1 Pubmed: 39261724 ]
- Regn5381 fab heavy chain (24 kDa, Protein from Mus musculus)
- Atrial natriuretic peptide receptor 1 (52 kDa, Protein from Homo sapiens)
- Regn5381 fab light chain (23 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Active complex of npr1 ectodomain, anp, and regn5381 fab (Complex from Homo sapiens)
- Atrial natriuretic peptide (3 kDa, Protein from Homo sapiens)
Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 8tga
Q-score: 0.117
Dunn ME, Kithcart A, Kim JH, Ho AJ, Franklin MC, Romero Hernandez A, de Hoon J, Botermans W, Meyer J, Jin X, Zhang D, Torello J, Jasewicz D, Kamat V, Garnova E, Liu N, Rosconi M, Pan H, Karnik S, Burczynski ME, Zheng W, Rafique A, Nielsen JB, De T, Verweij N, Pandit A, Locke A, Chalasani N, Melander O, Schwantes-An TH, Baras A, Lotta LA, Musser BJ, Mastaitis J, Devalaraja-Narashimha KB, Rankin AJ, Huang T, Herman G, Olson W, Murphy AJ, Yancopoulos GD, Olenchock BA, Morton L
Nature (2024) 633 pp. 654-661 [ DOI: doi:10.1038/s41586-024-07903-1 Pubmed: 39261724 ]
- Active-like complex of npr1 ectodomain and regn5381 fab, with no anp present (Complex from Homo sapiens)
- Regn5381 fab heavy chain (24 kDa, Protein from Mus musculus)
- Regn5381 fab light chain (23 kDa, Protein from Mus musculus)
- Atrial natriuretic peptide receptor 1 (52 kDa, Protein from Homo sapiens)
Human gamma-secretase treated with ganglioside GM1
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8im7
Q-score: 0.483
Wang X, Zhou R, Sun X, Li J, Wang J, Yue W, Wang L, Liu H, Shi Y, Zhang D
Adv Sci (2023) 10 pp. e2303411-e2303411 [ Pubmed: 37759382 DOI: doi:10.1002/advs.202303411 ]
- Presenilin-1 ctf12 (52 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Gamma-secretase subunit pen-2 (12 kDa, Protein from Homo sapiens)
- Nicastrin (78 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Human gamma-secretase treated with ganglioside gm1 (Complex from Homo sapiens)
- Gamma-secretase subunit aph-1a (29 kDa, Protein from Homo sapiens)
SARS-CoV-2 Omicron BA.1 spike protein receptor-binding domain in complex with white-tailed deer ACE2
Resolution: 3.21 Å
EM Method: Single-particle
Fitted PDBs: 8hfy
Q-score: 0.506
Han P, Meng Y, Zhang D, Xu Z, Li Z, Pan X, Zhao Z, Li L, Tang L, Qi J, Liu K, Gao GF
J Virol (2023) 97 pp. e0050523-e0050523 [ DOI: doi:10.1128/jvi.00505-23 Pubmed: 37676003 ]
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 omicron ba.1 spike protein receptor-binding domain in complex with white-tailed deer ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Angiotensin-converting enzyme (69 kDa, Protein from Odocoileus virginianus texanus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of SARS-CoV-2 prototype spike protein in complex with white-tailed deer ACE2
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8hfz
Q-score: 0.423
Han P, Meng Y, Zhang D, Xu Z, Li Z, Pan X, Zhao Z, Li L, Tang L, Qi J, Liu K, Gao GF
J Virol (2023) 97 pp. e0050523-e0050523 [ DOI: doi:10.1128/jvi.00505-23 Pubmed: 37676003 ]
- Angiotensin-converting enzyme (76 kDa, Protein from Odocoileus virginianus texanus)
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 prototype spike protein in complex with white-tailed deer ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (135 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 8hg0
Q-score: 0.42
Han P, Meng Y, Zhang D, Xu Z, Li Z, Pan X, Zhao Z, Li L, Tang L, Qi J, Liu K, Gao GF
J Virol (2023) 97 pp. e0050523-e0050523 [ DOI: doi:10.1128/jvi.00505-23 Pubmed: 37676003 ]
- Angiotensin-converting enzyme (71 kDa, Protein from Odocoileus virginianus texanus)
- Zinc ion (65 Da, Ligand)
- Sars-cov-2 prototype spike protein receptor-binding domain in complex with white-tailed deer ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (21 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 Omicron BA.4/5 spike protein in complex with white-tailed deer ACE2
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 8ify
Q-score: 0.382
Han P, Meng Y, Zhang D, Xu Z, Li Z, Pan X, Zhao Z, Li L, Tang L, Qi J, Liu K, Gao GF
J Virol (2023) 97 pp. e0050523-e0050523 [ DOI: doi:10.1128/jvi.00505-23 Pubmed: 37676003 ]
- Spike glycoprotein (125 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Angiotensin-converting enzyme (76 kDa, Protein from Odocoileus virginianus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cryo-em structure of sars-cov-2 omicron ba.4/5 spike protein in complex with white-tailed deer ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8ifz
Q-score: 0.447
Han P, Meng Y, Zhang D, Xu Z, Li Z, Pan X, Zhao Z, Li L, Tang L, Qi J, Liu K, Gao GF
J Virol (2023) 97 pp. e0050523-e0050523 [ DOI: doi:10.1128/jvi.00505-23 Pubmed: 37676003 ]
- Sars-cov-2 omicron ba.4/5 spike protein receptor-binding domain in complex with white-tailed deer ace2 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Zinc ion (65 Da, Ligand)
- Angiotensin-converting enzyme (76 kDa, Protein from Odocoileus virginianus)
- Spike protein s1 (26 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-61432059
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ayl
Q-score: 0.511
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ DOI: doi:10.1038/s41467-023-37259-5 Pubmed: 36966141 ]
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- 5-[2-(4-fluorophenyl)-7-(4-oxidanylpiperidin-1-yl)pyrazolo[1,5-c]pyrimidin-3-yl]-1,3-dihydroindol-2-one (443 Da, Ligand)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Resting state glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand jnj-61432059 (Complex from Rattus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and ligand JNJ-55511118
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8aym
Q-score: 0.472
Zhang D, Lape R, Shaikh SA, Kohegyi BK, Watson JF, Cais O, Nakagawa T, Greger IH
Nat Commun (2023) 14 pp. 1659-1659 [ DOI: doi:10.1038/s41467-023-37259-5 Pubmed: 36966141 ]
- Palmitic acid (256 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- {[7-morpholin-4-yl-2,3-dioxo-6-(trifluoromethyl)-3,4-dihydroquinoxalin-1(2h)-yl]methyl}phosphonic acid (409 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- 6-[2-chloro-6-(trifluoromethoxy)phenyl]-1h-benzimidazol-2-ol (328 Da, Ligand)
- Glua1/a2 ampa receptor in complex with tarp gamma 8 and ligand jnj-55511118 (Complex from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)