Active state of GluA1/2 in complex with TARP gamma 8, L-glutamate and CTZ
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7qhb
Q-score: 0.453
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ Pubmed: 35136046 DOI: doi:10.1038/s41467-022-28404-7 ]
- Cyclothiazide (389 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Palmitoleic acid (254 Da, Ligand)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- (2s)-2,3-dihydroxypropyl (7z)-hexadec-7-enoate (328 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
Active state of GluA1/A2 AMPA receptor in complex with TARP gamma-8 (TMD)
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ Pubmed: 35136046 DOI: doi:10.1038/s41467-022-28404-7 ]
- Ampa glutamate receptor 1, isoform flip (Protein from Rattus norvegicus)
- Tarp gamma 8 (Protein from Rattus norvegicus)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- Ampa glutamate receptor 2, isoform flip, q/r edited (Protein from Rattus norvegicus)
Active state of GluA1/A2 AMPA receptor in complex with TARP gamma-8 (LBD)
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ Pubmed: 35136046 DOI: doi:10.1038/s41467-022-28404-7 ]
- Ampa glutamate receptor 1, isoform flip (Protein from Rattus norvegicus)
- Ampa glutamate receptor 2, isoform flip, q/r edited (Protein from Rattus norvegicus)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- Tarp gamma 8 (Protein from Rattus norvegicus)
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD-LBD)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7qhh
Q-score: 0.359
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ Pubmed: 35136046 DOI: doi:10.1038/s41467-022-28404-7 ]
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Palmitoleic acid (254 Da, Ligand)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- (2r)-2,3-dihydroxypropyl (9z)-octadec-9-enoate (356 Da, Ligand)
- Glutamic acid (147 Da, Ligand)
- (2s)-2,3-dihydroxypropyl (7z)-hexadec-7-enoate (328 Da, Ligand)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (TMD)
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ Pubmed: 35136046 DOI: doi:10.1038/s41467-022-28404-7 ]
- Ampa glutamate receptor 2, flip isoform, q/r edited (Protein from Rattus norvegicus)
- Ampa glutamate receptor 1, flip isoform (Protein from Rattus norvegicus)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- Tarp gamma 8 (Protein from Rattus norvegicus)
Desensitized state of GluA1/2 AMPA receptor in complex with TARP-gamma 8 (LBD)
Herguedas B, Kohegyi BK, Dohrke JN, Watson JF, Zhang D, Ho H, Shaikh SA, Lape R, Krieger JM, Greger IH
Nat Commun (2022) 13 pp. 734-734 [ Pubmed: 35136046 DOI: doi:10.1038/s41467-022-28404-7 ]
- Ampa glutamate receptor 2, flip isoform, q/r edited (Protein from Rattus norvegicus)
- Tarp-gamma 8 (Protein from Rattus norvegicus)
- Complex between glua1/2 ampa receptor and auxiliary subunit tarp gamma8 (490 kDa, Complex from Rattus norvegicus)
- Glua1 ampa glutamate receptor 1, flip isoform (Protein from Rattus norvegicus)
Resting state GluA1/A2 heterotetramer in complex with auxiliary subunit TARP gamma 8 (LBD-TMD)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7ocd
Q-score: 0.495
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ DOI: doi:10.1038/s41586-021-03613-0 Pubmed: 34079129 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide (336 Da, Ligand)
- Glua1/a2 heterotetramer in complex with auxiliary subunit tarp gamma 8 (Complex from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
Resting state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7oce
Q-score: 0.541
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ DOI: doi:10.1038/s41586-021-03613-0 Pubmed: 34079129 ]
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Glua1/a2 heterotetramer in complex with auxiliary subunits tarp gamma 8 and cnih2 (527 kDa, Complex from Rattus norvegicus)
- Glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- 6-nitro-2,3-bis(oxidanylidene)-1,4-dihydrobenzo[f]quinoxaline-7-sulfonamide (336 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Protein cornichon homolog 2 (22 kDa, Protein from Rattus norvegicus)
- Glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)
Active state GluA1/A2 AMPA receptor in complex with TARP gamma 8 and CNIH2 (LBD-TMD)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7ocf
Q-score: 0.465
Zhang D, Watson JF, Matthews PM, Cais O, Greger IH
Nature (2021) 594 pp. 454-458 [ DOI: doi:10.1038/s41586-021-03613-0 Pubmed: 34079129 ]
- Cyclothiazide (389 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Isoform flip of glutamate receptor 2 (96 kDa, Protein from Rattus norvegicus)
- Glua1/a2 heterotetramer in complex with auxiliary subunits tarp gamma 8 and cnih2 (527 kDa, Complex from Rattus norvegicus)
- Glutamic acid (147 Da, Ligand)
- Protein cornichon homolog 2 (22 kDa, Protein from Rattus norvegicus)
- Voltage-dependent calcium channel gamma-8 subunit (43 kDa, Protein from Rattus norvegicus)
- Isoform flip of glutamate receptor 1 (102 kDa, Protein from Rattus norvegicus)