CryoEM structure of human XPR1 in complex with phosphate in state A
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9j51
Q-score: 0.468
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Human xpr1 (Complex from Homo sapiens)
CryoEM structure of human XPR1 in complex with phosphate in state B
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9j52
Q-score: 0.468
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Human xpr1 (Complex from Homo sapiens)
CryoEM structure of human XPR1 in complex with phosphate in state C
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9j53
Q-score: 0.413
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Human xpr1 (Complex from Homo sapiens)
CryoEM structure of human XPR1 in apo state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9j4x
Q-score: 0.554
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Human xpr1 (Complex from Homo sapiens)
Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8tg9
Q-score: 0.495
Dunn ME, Kithcart A, Kim JH, Ho AJ, Franklin MC, Romero Hernandez A, de Hoon J, Botermans W, Meyer J, Jin X, Zhang D, Torello J, Jasewicz D, Kamat V, Garnova E, Liu N, Rosconi M, Pan H, Karnik S, Burczynski ME, Zheng W, Rafique A, Nielsen JB, De T, Verweij N, Pandit A, Locke A, Chalasani N, Melander O, Schwantes-An TH, Baras A, Lotta LA, Musser BJ, Mastaitis J, Devalaraja-Narashimha KB, Rankin AJ, Huang T, Herman G, Olson W, Murphy AJ, Yancopoulos GD, Olenchock BA, Morton L
Nature (2024) 633 pp. 654-661 [ DOI: doi:10.1038/s41586-024-07903-1 Pubmed: 39261724 ]
- Atrial natriuretic peptide (3 kDa, Protein from Homo sapiens)
- Atrial natriuretic peptide receptor 1 (52 kDa, Protein from Homo sapiens)
- Active complex of npr1 ectodomain, anp, and regn5381 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Regn5381 fab light chain (23 kDa, Protein from Mus musculus)
- Regn5381 fab heavy chain (24 kDa, Protein from Mus musculus)
Complex of NPR1 ectodomain and REGN5381 Fab in an active-like state with no ANP bound
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 8tga
Q-score: 0.117
Dunn ME, Kithcart A, Kim JH, Ho AJ, Franklin MC, Romero Hernandez A, de Hoon J, Botermans W, Meyer J, Jin X, Zhang D, Torello J, Jasewicz D, Kamat V, Garnova E, Liu N, Rosconi M, Pan H, Karnik S, Burczynski ME, Zheng W, Rafique A, Nielsen JB, De T, Verweij N, Pandit A, Locke A, Chalasani N, Melander O, Schwantes-An TH, Baras A, Lotta LA, Musser BJ, Mastaitis J, Devalaraja-Narashimha KB, Rankin AJ, Huang T, Herman G, Olson W, Murphy AJ, Yancopoulos GD, Olenchock BA, Morton L
Nature (2024) 633 pp. 654-661 [ DOI: doi:10.1038/s41586-024-07903-1 Pubmed: 39261724 ]
- Regn5381 fab heavy chain (24 kDa, Protein from Mus musculus)
- Active-like complex of npr1 ectodomain and regn5381 fab, with no anp present (Complex from Homo sapiens)
- Regn5381 fab light chain (23 kDa, Protein from Mus musculus)
- Atrial natriuretic peptide receptor 1 (52 kDa, Protein from Homo sapiens)
Cloprosetnol bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.63 Å
EM Method: Single-particle
Fitted PDBs: 8xjk
Q-score: 0.588
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Cloprostenol (424 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cloprosetnol-fp-minigq-scfv16 complex (Complex from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.77 Å
EM Method: Single-particle
Fitted PDBs: 8xjl
Q-score: 0.559
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Pgf2-alpha-fp-minigq-scfv16 complex (Complex from Homo sapiens)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- (z)-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(e,3s)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid (354 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
Latanoprost acid bound Prostaglandin F2-alpha receptor-Gq Protein Complex
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8xjm
Q-score: 0.555
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Fusion tag,prostaglandin f2-alpha receptor,lgbit (64 kDa, Protein from synthetic construct)
- Z-7-[(1r,2r,3r,5s)-3,5-bis(oxidanyl)-2-[(3r)-3-oxidanyl-5-phenyl-pentyl]cyclopentyl]hept-5-enoic acid (390 Da, Ligand)
- Latanoprost acid-fp-minigq-scfv16 complex (Complex from Homo sapiens)
- Engineered minigq (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8xjn
Q-score: 0.509
Li X, Zhang X, Wen X, Zhang D, Qu C, Miao X, Zhang W, Zhang R, Liu G, Xiao P, Sun JP, Gong W
Cell Rep (2024) 43 pp. 113893-113893 [ Pubmed: 38446662 DOI: doi:10.1016/j.celrep.2024.113893 ]
- Cloprosetnol-tp-minigq-scfv16 complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Antibody fragment scfv16 (27 kDa, Protein from synthetic construct)
- Cloprostenol (424 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Fusion tag,thromboxane a2 receptor,lgbit (61 kDa, Protein from synthetic construct)
- Engineered minigq (28 kDa, Protein from synthetic construct)