Cryo-EM structure of noradrenaline transporter in apo state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wtu
Q-score: 0.614
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ Pubmed: 39085602 DOI: doi:10.1038/s41586-024-07638-z ]
- Structure of a protein (63 MDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
Cryo-EM structure of noradrenaline transporter in complex with noradrenaline
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wtv
Q-score: 0.655
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ Pubmed: 39085602 DOI: doi:10.1038/s41586-024-07638-z ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Water (18 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Noradrenaline (170 Da, Ligand)
Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8wtw
Q-score: 0.617
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ Pubmed: 39085602 DOI: doi:10.1038/s41586-024-07638-z ]
- Apo (Complex from Homo sapiens)
- Mrla (1 kDa, Protein from Conus marmoreus)
- Sodium ion (22 Da, Ligand)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of noradrenaline transporter in complex with bupropion
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8wtx
Q-score: 0.58
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ Pubmed: 39085602 DOI: doi:10.1038/s41586-024-07638-z ]
- (2~{r})-2-(~{tert}-butylamino)-1-(3-chlorophenyl)propan-1-one (239 Da, Ligand)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
Cryo-EM structure of noradrenaline transporter in complex with ziprasidone
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wty
Q-score: 0.549
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ Pubmed: 39085602 DOI: doi:10.1038/s41586-024-07638-z ]
- Structure of a protein (63 MDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Ziprasidone (412 Da, Ligand)
SARS-CoV-2 Spike RBD (dimer) in complex with two 2S-1244 nanobodies
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 8jys
Q-score: 0.331
Local refinement of FEM1B bound with the C-degron of CCC89
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8wqd
Q-score: 0.5
Local refinement of FEM1B bound with the C-degron of CUX1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8wqi
Q-score: 0.47
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Protein casp (3 kDa, Protein from Homo sapiens)
- Local refinement of fem1b bound with the c-degron of cux1 (Complex from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8iyx
Q-score: 0.448
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S
PNAS (2023) 120 pp. e2308435120-e2308435120 [ DOI: doi:10.1073/pnas.2308435120 Pubmed: 37733739 ]
- Cryo-em structure of the gpr34 receptor in complex with the antagonist yl-365 (Complex from Homo sapiens)
- 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid (583 Da, Ligand)
- Probable g-protein coupled receptor 34,probable g-protein coupled receptor 34,yl-365 (66 kDa, Protein from Homo sapiens)
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8iv4
Q-score: 0.506
Sun H, Deng T, Zhang Y, Lin Y, Jiang Y, Jiang Y, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S, Zheng Q, Gu Y, Xia N
Protein Cell (2024) 15 pp. 121-134 [ DOI: doi:10.1093/procel/pwad040 Pubmed: 37470320 ]
- Heavy chain of 8h12 (13 kDa, Protein from Mus musculus)
- Light chain of 8h12 (11 kDa, Protein from Mus musculus)
- Cryo-em structure of sars-cov-2 spike protein in complex with double nabs 3e2 and 1c4 (Complex)
- Heavy chain of 3e2 (13 kDa, Protein from Mus musculus)
- Light chain of 3e2 (11 kDa, Protein from Mus musculus)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Nabs 8h12 and 3e2 (Complex from Mus musculus)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)