Cryo-EM structure of noradrenaline transporter in apo state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wtu
Q-score: 0.614
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
Cryo-EM structure of noradrenaline transporter in complex with noradrenaline
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wtv
Q-score: 0.655
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- Water (18 Da, Ligand)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Noradrenaline (170 Da, Ligand)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8wtw
Q-score: 0.617
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Mrla (1 kDa, Protein from Conus marmoreus)
- Apo (Complex from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Cryo-EM structure of noradrenaline transporter in complex with bupropion
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8wtx
Q-score: 0.58
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- (2~{r})-2-(~{tert}-butylamino)-1-(3-chlorophenyl)propan-1-one (239 Da, Ligand)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
Cryo-EM structure of noradrenaline transporter in complex with ziprasidone
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wty
Q-score: 0.549
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- Ziprasidone (412 Da, Ligand)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
Acinetobacter GP16 Type IV pilus
Resolution: 3.14 Å
EM Method: Helical reconstruction
Fitted PDBs: 8tob
Q-score: 0.586
Meng R, Xing Z, Chang JY, Yu Z, Thongchol J, Xiao W, Wang Y, Chamakura K, Zeng Z, Wang F, Young R, Zeng L, Zhang J
Nat Commun (2024) 15 pp. 2746-2746 [ Pubmed: 38553443 DOI: doi:10.1038/s41467-024-47119-5 ]
- Acinetobacter genomosp.16 tyoe iv pilus (11 MDa, Complex from Acinetobacter genomosp. 16BJ)
- Fimbrial protein (7 kDa, Protein from Acinetobacter genomosp. 16BJ)
- Fimbrial protein (6 kDa, Protein from Acinetobacter genomosp. 16BJ)
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 8toc
Q-score: 0.354
Meng R, Xing Z, Chang JY, Yu Z, Thongchol J, Xiao W, Wang Y, Chamakura K, Zeng Z, Wang F, Young R, Zeng L, Zhang J
Nat Commun (2024) 15 pp. 2746-2746 [ Pubmed: 38553443 DOI: doi:10.1038/s41467-024-47119-5 ]
- Rna (4269-mer) (1 MDa, RNA from Bacteria abnormis)
- Coat protein (13 kDa, Protein from Acinetobacter phage AP205)
- Maturation protein (61 kDa, Protein from Acinetobacter phage AP205)
- Acinetobacter phage ap205 (3 MDa, Virus from Acinetobacter phage AP205)
AP205 binding to one Acinetobacter GP16 type iv pilus
Meng R, Xing Z, Chang JY, Yu Z, Thongchol J, Xiao W, Wang Y, Chamakura K, Zeng Z, Wang F, Young R, Zeng L, Zhang J
Nat Commun (2024) 15 pp. 2746-2746 [ Pubmed: 38553443 DOI: doi:10.1038/s41467-024-47119-5 ]
- Acinetobacter phage ap205 (4 MDa, Virus from Acinetobacter phage AP205)
Resolution: 8.15 Å
EM Method: Single-particle
Fitted PDBs: 8tv9
Q-score: 0.081
Meng R, Xing Z, Chang JY, Yu Z, Thongchol J, Xiao W, Wang Y, Chamakura K, Zeng Z, Wang F, Young R, Zeng L, Zhang J
Nat Commun (2024) 15 pp. 2746-2746 [ Pubmed: 38553443 DOI: doi:10.1038/s41467-024-47119-5 ]
- Acinetobacter phage ap205 (378 kDa, Virus from Acinetobacter phage AP205)
- Maturation protein (61 kDa, Protein from Acinetobacter phage AP205)
- Fimbrial protein (7 kDa, Protein from Acinetobacter genomosp. 16BJ)
- Fimbrial protein (6 kDa, Protein from Acinetobacter genomosp. 16BJ)
Resolution: 8.55 Å
EM Method: Single-particle
Fitted PDBs: 8tva
Q-score: 0.054
Meng R, Xing Z, Chang JY, Yu Z, Thongchol J, Xiao W, Wang Y, Chamakura K, Zeng Z, Wang F, Young R, Zeng L, Zhang J
Nat Commun (2024) 15 pp. 2746-2746 [ Pubmed: 38553443 DOI: doi:10.1038/s41467-024-47119-5 ]
- Acinetobacter phage ap205 (378 kDa, Virus from Acinetobacter phage AP205)
- Maturation protein (61 kDa, Protein from Acinetobacter phage AP205)
- Fimbrial protein (7 kDa, Protein from Acinetobacter genomosp. 16BJ)
- Fimbrial protein (6 kDa, Protein from Acinetobacter genomosp. 16BJ)