Cryo-EM structure of membrane transporter with inhibitor G
He Z, Zhang J, Xu Y, Fine EJ, Suomivuori CM, Dror RO, Feng L
Nature (2025) [ DOI: doi:10.1038/s41586-025-08667-y ]
- Mitochondrial pyruvate carrier 2 (14 kDa, Protein from Homo sapiens)
- Mitochondrial pyruvate carrier 1 (13 kDa, Protein from Homo sapiens)
- Human mpc with gw604714x (Complex from Homo sapiens)
- Mbp-pra/g (59 kDa, Protein from Escherichia coli)
- Fab_8d3_2 heavy chain (28 kDa, Protein from Mus musculus)
- Nanobody (16 kDa, Protein from synthetic construct)
- (5e)-5-({(5p)-5-[6-(4-acetylpiperazin-1-yl)-3-nitropyridin-2-yl]-2-fluorophenyl}methylidene)-1,3-thiazolidine-2,4-dione (471 Da, Ligand)
- Fab_8d3_2 light chain (27 kDa, Protein from Mus musculus)
Cryo-EM structure of human MPC in complex with UK5099 in LMNG
He Z, Zhang J, Xu Y, Fine EJ, Suomivuori CM, Dror RO, Feng L
Nature (2025) [ DOI: doi:10.1038/s41586-025-08667-y ]
- Mitochondrial pyruvate carrier 2 (14 kDa, Protein from Homo sapiens)
- Mitochondrial pyruvate carrier 1 (13 kDa, Protein from Homo sapiens)
- Mbp-pra/g (59 kDa, Protein from Escherichia coli)
- (e)-2-cyano-3-(1-phenylindol-3-yl)prop-2-enoic acid (288 Da, Ligand)
- Fab_8d3_2 heavy chain (28 kDa, Protein from Mus musculus)
- Nanobody (16 kDa, Protein from synthetic construct)
- Human mpc in lmng with uk5099 (Complex from Homo sapiens)
- Fab_8d3_2 light chain (27 kDa, Protein from Mus musculus)
Structure of the human GluN1-N2B NMDA receptors in the Mg2+ bound state
Huang X, Sun X, Wang Q, Zhang J, Wen H, Chen WJ, Zhu S
Neuron (2025) [ DOI: doi:10.1016/j.neuron.2025.01.021 ]
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2b (90 kDa, Protein from Homo sapiens)
- Human glun1-n2b receptors in the mg2+-bond state (Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (91 kDa, Protein from Homo sapiens)
- Glycine (75 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of the human GluN1-N2B NMDA receptors in the Mg2+ free state
Huang X, Sun X, Wang Q, Zhang J, Wen H, Chen WJ, Zhu S
Neuron (2025) [ DOI: doi:10.1016/j.neuron.2025.01.021 ]
- (2r)-4-(3-phosphonopropyl)piperazine-2-carboxylic acid (252 Da, Ligand)
- Human glun1-n2b receptors in the mg2+-free state (Complex from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- Glutamate receptor ionotropic, nmda 2b (94 kDa, Protein from Homo sapiens)
- Glycine (75 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the receptor of xGPR4-Gs complex in pH6.2
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8zf4
Q-score: 0.497
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Cryo-EM structure of the receptor of xGPR4-Gs complex in pH6.7
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8zf7
Q-score: 0.495
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Cryo-EM structure of the receptor of xtGPR4-Gs complex in pH7.2
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8zfb
Q-score: 0.433
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Cryo-EM structure of partial VP4 from simian rotavirus SA11
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 8ygr
Q-score: 0.413
Huang Y, Song F, Zeng Y, Sun H, Sheng R, Wang X, Liu L, Luo G, Jiang Y, Chen Y, Zhang M, Zhang S, Gu Y, Yu H, Li S, Li T, Zheng Q, Ge S, Zhang J, Xia N
Nat Commun (2025) 16 pp. 838-838 [ Pubmed: 39833145 DOI: doi:10.1038/s41467-025-56114-3 ]
- Partial vp4 of rotavirus (Complex from Rotavirus A)
- Outer capsid protein vp4 (64 kDa, Protein from Rotavirus A)
- Rotavirus a (Virus from Rotavirus A)
- Outer capsid protein vp4 (64 kDa, Protein from Rotavirus A)
- Outer capsid protein vp4 (64 kDa, Protein from Rotavirus A)
Cryo-EM structure of simian rotavirus SA11 VP4 in complex with nAb 7H13
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8ygs
Q-score: 0.444
Huang Y, Song F, Zeng Y, Sun H, Sheng R, Wang X, Liu L, Luo G, Jiang Y, Chen Y, Zhang M, Zhang S, Gu Y, Yu H, Li S, Li T, Zheng Q, Ge S, Zhang J, Xia N
Nat Commun (2025) 16 pp. 838-838 [ Pubmed: 39833145 DOI: doi:10.1038/s41467-025-56114-3 ]
- Rotavirus vp4 (Complex from Rotavirus A)
- Immune complex of rotavirus with 7h13 (Complex from Rotavirus A)
- Fab 7h13 (Complex from Mus musculus)
- Antibody 7h13 heavy chain (12 kDa, Protein from Mus musculus)
- Outer capsid protein vp4 (64 kDa, Protein from Rotavirus A)
- Antibody 7h13 light chain (11 kDa, Protein from Mus musculus)
- Outer capsid protein vp4 (64 kDa, Protein from Rotavirus A)
Cryo-EM structure of simian rotavirus SA11 VP4 in complex with nAb 7H13-I54G mutant (left side)
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8ygt
Q-score: 0.559
Huang Y, Song F, Zeng Y, Sun H, Sheng R, Wang X, Liu L, Luo G, Jiang Y, Chen Y, Zhang M, Zhang S, Gu Y, Yu H, Li S, Li T, Zheng Q, Ge S, Zhang J, Xia N
Nat Commun (2025) 16 pp. 838-838 [ Pubmed: 39833145 DOI: doi:10.1038/s41467-025-56114-3 ]
- Rotavirus vp4 (Complex from Rotavirus A)
- Immune complex of rotavirus with 7h13 (Complex from Rotavirus A)
- Fab 7h13 (Complex from Mus musculus)
- Antibody 7h13-i54g mutant heavy chain (12 kDa, Protein from Mus musculus)
- Antibody 7h13-i54g mutant light chain (11 kDa, Protein from Mus musculus)
- Outer capsid protein vp4 (64 kDa, Protein from Rotavirus A)