The structure of EfpA_BRD-8000.3 complex
Resolution: 3.41 Å
EM Method: Single-particle
Fitted PDBs: 8ynz
Q-score: 0.406
Li D, Zhang X, Yao Y, Sun X, Sun J, Ma X, Yuan K, Bai G, Pang X, Hua R, Guo T, Mi Y, Wu L, Zhang J, Wu Y, Liu Y, Wang P, Wong CCL, Chen XW, Xiao H, Gao GF, Gao F
PNAS (2024) 121 pp. e2412653121-e2412653121 [ Pubmed: 39441632 DOI: doi:10.1073/pnas.2412653121 ]
- Uncharacterized mfs-type transporter efpa (59 kDa, Protein from Mycobacterium tuberculosis H37Rv)
- Efpa (Complex from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv))
- (1s,3s)-n-[6-bromo-5-(pyrimidin-2-yl)pyridin-2-yl]-2,2-dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carboxamide (401 Da, Ligand)
Cryo-EM structure of Tdk1-Bdf1 complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 9ja5
Q-score: 0.524
Structure of L797591-SSTR1 G protein complex
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8xio
Q-score: 0.469
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- L797591-sstr1 g protein complex (160 kDa, Complex from Homo sapiens)
- G-alpha-i (41 kDa, Protein from Homo sapiens)
- (2~{s})-~{n}-[(4~{s})-6-azanyl-2,2,4-trimethyl-hexyl]-3-naphthalen-1-yl-2-[[2-phenylethyl(2-pyridin-2-ylethyl)carbamoyl]amino]propanamide (607 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 1 (42 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Structure of Pasireotide-SSTR1 G protein complex
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8xip
Q-score: 0.384
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- 004-dtr-lys-ty5-phe-a1d5e (1 kDa, Protein from synthetic construct)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Pasireotide-sstr1 g protein complex (160 kDa, Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 1 (42 kDa, Protein from Homo sapiens)
Structure of L796778-SSTR3 G protein complex
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 8xiq
Q-score: 0.462
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Structure of l796778-sstr3 g protein complex (160 kDa, Complex from Homo sapiens)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Nit-fc0-nle-a1d5b (584 Da, Protein from synthetic construct)
- Somatostatin receptor type 3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (40 kDa, Protein from Homo sapiens)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Structure of pasireotide-SSTR3 G protein complex
Resolution: 2.52 Å
EM Method: Single-particle
Fitted PDBs: 8xir
Q-score: 0.501
Wang Y, Xu Y, Wang Y, Zhang J, Chen L, He X, Fan W, Wu K, Hu W, Cheng X, Yang G, Xu HE, Zhuang Y, Sun S
PNAS (2024) 121 pp. e2400298121-e2400298121 [ DOI: doi:10.1073/pnas.2400298121 Pubmed: 39361640 ]
- Pasireotide-sstr3 g protein complex (160 kDa, Complex from Homo sapiens)
- G-alpha i (41 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 3 (45 kDa, Protein from Homo sapiens)
- Pasireotide (1 kDa, Protein from synthetic construct)
- Nanobody nb35 (16 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S
PNAS (2023) 120 pp. e2308435120-e2308435120 [ DOI: doi:10.1073/pnas.2308435120 Pubmed: 37733739 ]
Cryo-EM map of Gi-scFv16 complex
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S
PNAS (2023) 120 pp. e2308435120-e2308435120 [ DOI: doi:10.1073/pnas.2308435120 Pubmed: 37733739 ]
Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8iyx
Q-score: 0.448
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S
PNAS (2023) 120 pp. e2308435120-e2308435120 [ DOI: doi:10.1073/pnas.2308435120 Pubmed: 37733739 ]
- Cryo-em structure of the gpr34 receptor in complex with the antagonist yl-365 (Complex from Homo sapiens)
- 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid (583 Da, Ligand)
- Probable g-protein coupled receptor 34,probable g-protein coupled receptor 34,yl-365 (66 kDa, Protein from Homo sapiens)