Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S
PNAS (2023) 120 pp. e2308435120-e2308435120 [ Pubmed: 37733739 DOI: doi:10.1073/pnas.2308435120 ]
Cryo-EM map of Gi-scFv16 complex
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S
PNAS (2023) 120 pp. e2308435120-e2308435120 [ Pubmed: 37733739 DOI: doi:10.1073/pnas.2308435120 ]
Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8iyx
Q-score: 0.448
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S
PNAS (2023) 120 pp. e2308435120-e2308435120 [ Pubmed: 37733739 DOI: doi:10.1073/pnas.2308435120 ]
- 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid (583 Da, Ligand)
- Probable g-protein coupled receptor 34,probable g-protein coupled receptor 34,yl-365 (66 kDa, Protein from Homo sapiens)
- Cryo-em structure of the gpr34 receptor in complex with the antagonist yl-365 (Complex from Homo sapiens)
Structure of CRL2APPBP2 bound with RxxGP degron (dimer)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jal
Q-score: 0.473
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- Leu-thr-arg-asn-lys-gly-pro (1 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
Structure of CRL2APPBP2 bound with RxxGP degron (tetramer)
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8jaq
Q-score: 0.443
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (12 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Xp_211896 c-degron (1 kDa, Protein from Homo sapiens)
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
Structure of CRL2APPBP2 bound with RxxGPAA degron (dimer)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8jar
Q-score: 0.468
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- Xp_211896+aa c-degron (1 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
Structure of CRL2APPBP2 bound with RxxGPAA degron (tetramer)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8jas
Q-score: 0.366
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- Sumo-xp_211896+aa c-degron (1 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (12 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (dimer)
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8jau
Q-score: 0.478
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- Mrpl28 c-degron (1 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
Structure of CRL2APPBP2 bound with the C-degron of MRPL28 (tetramer)
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 8jav
Q-score: 0.421
Zhao S, Olmayev-Yaakobov D, Ru W, Li S, Chen X, Zhang J, Yao X, Koren I, Zhang K, Xu C
PNAS (2023) 120 pp. e2308870120-e2308870120 [ DOI: doi:10.1073/pnas.2308870120 Pubmed: 37844242 ]
- Crl2appbp2 e3 liganse (400 MDa, Complex from Homo sapiens)
- Mrpl28 c-degron (1 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (12 kDa, Protein from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Amyloid protein-binding protein 2 (66 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of GPR34-Gi complex
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8sai
Q-score: 0.471
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S
PNAS (2023) 120 pp. e2308435120-e2308435120 [ Pubmed: 37733739 DOI: doi:10.1073/pnas.2308435120 ]
- Scfv16 (Complex from Mus musculus)
- Human gpr34 in complex with gi heterotrimer and scfv16 (Complex)
- O-[(s)-hydroxy{[(2s)-2-hydroxy-3-(octadec-9-enoyloxy)propyl]oxy}phosphoryl]-l-serine (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 34 (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Soluble cytochrome b562,probable g-protein coupled receptor 34, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, guanine nucleotide-binding protein g(i) subunit alpha-1, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)