Integrin alpha-v beta-8 in complex with the Fab of 130H2
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 9ind
Q-score: 0.533
Guo C, Sun H, Du Y, Dai X, Pang Y, Han Z, Xiong X, Li S, Zhang J, Zheng Q, Gui X
J Exp Clin Cancer Res (2025) 44 pp. 1-1 [ DOI: doi:10.1186/s13046-024-03250-1 Pubmed: 39743547 ]
- Integrin alpha-v beta-8 complexed with antibody fab fragment of 130h2 (Complex)
- Integrin beta-8 (39 kDa, Protein from Homo sapiens)
- 130h2-fab (Complex from Mus musculus)
- The light chain of 130h2-fab (11 kDa, Protein from Mus musculus)
- Integrin alpha-v beta-8 (Complex from Homo)
- Integrin alpha-v heavy chain (47 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The heavy chain of 130h2-fab (13 kDa, Protein from Mus musculus)
CryoEM structure of compound HNC-1664 bound with RdRP-RNA complex of SARS-CoV-2
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8xko
Q-score: 0.486
Jia X, Jing X, Li M, Gao M, Zhong Y, Li E, Liu Y, Li R, Yao G, Liu Q, Zhou M, Hou Y, An L, Hong Y, Li S, Zhang J, Wang W, Zhang K, Gong P, Chiu S
Nat Commun (2024) 15 pp. 10750-10750 [ Pubmed: 39737930 DOI: doi:10.1038/s41467-024-54918-3 ]
- Rna (5'-r(p*up*up*cp*ap*up*gp*cp*up*ap*cp*gp*cp*gp*up*ap*g)-3') (5 kDa, RNA from synthetic construct)
- Magnesium ion (24 Da, Ligand)
- Non-structural protein 7 (10 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Rna (5'-r(p*cp*up*ap*cp*gp*cp*gp*up*ap*gp*cp*ap*up*g)-3') (4 kDa, RNA from synthetic construct)
- Cryoem structure of compound hnc-1644 bound with rdrp-rna (150 kDa, Complex from Severe acute respiratory syndrome coronavirus)
- [[(2~{r},3~{r},4~{s},5~{r})-4-fluoranyl-5-(5-iodanyl-4-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (633 Da, Ligand)
- Rna-directed rna polymerase nsp12 (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 8 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus)
Cryo-EM structure of human HCN3 channel with cAMP
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8io0
Q-score: 0.42
Resolution: 3.94 Å
EM Method: Single-particle
Fitted PDBs: 8kci
Q-score: 0.356
Huang Y, Xue C, Bu R, Wu C, Li J, Zhang J, Chen J, Shi Z, Chen Y, Wang Y, Liu Z
Nat Commun (2024) 15 pp. 4811-4811 [ Pubmed: 38844452 DOI: doi:10.1038/s41467-024-49204-1 ]
- Atp-bound hmrp5 outward-open (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-binding cassette sub-family c member 5 (160 kDa, Protein from Homo sapiens)
Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1)
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8wqa
Q-score: 0.362
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Cryo-em structure of cul2-rbx1-elob-eloc-fem1b bound with the c-degron of ccdc89 (conformation 1) (Complex from Homo sapiens)
- Coiled-coil domain-containing protein 89 (3 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2)
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8wqb
Q-score: 0.39
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Coiled-coil domain-containing protein 89 (3 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Cryo-em structure of cul2-rbx1-elob-eloc-fem1b bound with the c-degron of ccdc89 (conformation 2) (Complex from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8wqc
Q-score: 0.352
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Cryo-em structure of neddylated cul2-rbx1-elob-eloc-fem1b bound with the c-degron of cdk5r1 (Complex from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 1)
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8wqe
Q-score: 0.372
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Protein casp (3 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Cryo-em structure of cul2-rbx1-elob-eloc-fem1b bound with the c-degron of cux1 (conformation 1) (Complex from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8wqf
Q-score: 0.439
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Protein casp (3 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Cryo-em structure of cul2-rbx1-elob-eloc-fem1b bound with the c-degron of cux1 (conformation 2) (Complex from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
Resolution: 4.09 Å
EM Method: Single-particle
Fitted PDBs: 8wqg
Q-score: 0.265
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Cryo-em structure of neddylated cul2-rbx1-elob-eloc-fem1b bound with the c-degron of ccdc89 (conformation 1) (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)