CryoEM structure of human XPR1 in complex with phosphate in state A
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9j51
Q-score: 0.468
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Human xpr1 (Complex from Homo sapiens)
CryoEM structure of human XPR1 in complex with phosphate in state B
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9j52
Q-score: 0.468
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Human xpr1 (Complex from Homo sapiens)
CryoEM structure of human XPR1 in complex with phosphate in state C
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 9j53
Q-score: 0.413
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Human xpr1 (Complex from Homo sapiens)
CryoEM structure of compound HNC-1664 bound with RdRP-RNA complex of SARS-CoV-2
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8xko
Q-score: 0.486
Jia X, Jing X, Li M, Gao M, Zhong Y, Li E, Liu Y, Li R, Yao G, Liu Q, Zhou M, Hou Y, An L, Hong Y, Li S, Zhang J, Wang W, Zhang K, Gong P, Chiu S
Nat Commun (2024) 15 pp. 10750-10750 [ Pubmed: 39737930 DOI: doi:10.1038/s41467-024-54918-3 ]
- [[(2~{r},3~{r},4~{s},5~{r})-4-fluoranyl-5-(5-iodanyl-4-methyl-pyrrolo[2,3-d]pyrimidin-7-yl)-3-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate (633 Da, Ligand)
- Rna (5'-r(p*up*up*cp*ap*up*gp*cp*up*ap*cp*gp*cp*gp*up*ap*g)-3') (5 kDa, RNA from synthetic construct)
- Non-structural protein 8 (23 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Magnesium ion (24 Da, Ligand)
- Rna (5'-r(p*cp*up*ap*cp*gp*cp*gp*up*ap*gp*cp*ap*up*g)-3') (4 kDa, RNA from synthetic construct)
- Cryoem structure of compound hnc-1644 bound with rdrp-rna (150 kDa, Complex from Severe acute respiratory syndrome coronavirus)
- Rna-directed rna polymerase nsp12 (108 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Non-structural protein 7 (10 kDa, Protein from Severe acute respiratory syndrome coronavirus)
CryoEM structure of human XPR1 in apo state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9j4x
Q-score: 0.554
Zhang W, Chen Y, Guan Z, Wang Y, Tang M, Du Z, Zhang J, Cheng M, Zuo J, Liu Y, Wang Q, Liu Y, Zhang D, Yin P, Ma L, Liu Z
Nat Commun (2025) 16 pp. 18-18 [ Pubmed: 39747008 DOI: doi:10.1038/s41467-024-55471-9 ]
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Solute carrier family 53 member 1 (84 kDa, Protein from Homo sapiens)
- Human xpr1 (Complex from Homo sapiens)
Cryo-EM structure of enterovirus A71 mature virion in complex with Fab h1A6.2
Zhu R, Wu Y, Huang Y, Jiang Y, Jiang Y, Zhang D, Sun H, Zhou Z, Zhou L, Weng S, Chen H, Chen X, Ning W, Zou Y, He M, Yang H, Deng W, Li Y, Chen Z, Ye X, Han J, Yin Z, Zhao H, Liu C, Que Y, Fang M, Yu H, Zhang J, Luo W, Li S, Zheng Q, Xu L, Xia N, Cheng T
Nat Microbiol (2024) 9 pp. 2939-2953 [ Pubmed: 39424982 DOI: doi:10.1038/s41564-024-01822-7 ]
- Enterovirus a71 mature virion in complex with fab h1a6.2 (Complex)
- Capsid protein vp4 (7 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Fab h1a6.2 (Complex from Mus)
- Capsid protein vp1 (32 kDa, Protein from Enterovirus A71)
- Capsid protein vp2 (27 kDa, Protein from Enterovirus A71)
- Capsid protein vp3 (26 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
Choline transporter BetT - CHT bound
Yang T, Nian Y, Lin H, Li J, Lin X, Li T, Wang R, Wang L, Beattie GA, Zhang J, Fan M
Sci Adv (2024) 10 pp. eado6229-eado6229 [ DOI: doi:10.1126/sciadv.ado6229 Pubmed: 39141726 ]
- Choline ion (104 Da, Ligand)
- Bcct family transporter (75 kDa, Protein from Pseudomonas syringae)
- Choline transporter bett (Complex from Pseudomonas syringae)
- Water (18 Da, Ligand)
Cryo-EM structure of enterovirus A71 mature virion
Zhu R, Wu Y, Huang Y, Jiang Y, Jiang Y, Zhang D, Sun H, Zhou Z, Zhou L, Weng S, Chen H, Chen X, Ning W, Zou Y, He M, Yang H, Deng W, Li Y, Chen Z, Ye X, Han J, Yin Z, Zhao H, Liu C, Que Y, Fang M, Yu H, Zhang J, Luo W, Li S, Zheng Q, Xu L, Xia N, Cheng T
Nat Microbiol (2024) 9 pp. 2939-2953 [ Pubmed: 39424982 DOI: doi:10.1038/s41564-024-01822-7 ]
- Capsid protein vp4 (7 kDa, Protein from Enterovirus A71)
- Sphingosine (299 Da, Ligand)
- Capsid protein vp1 (32 kDa, Protein from Enterovirus A71)
- Capsid protein vp2 (27 kDa, Protein from Enterovirus A71)
- Capsid protein vp3 (26 kDa, Protein from Enterovirus A71)
- Enterovirus a71 (Virus from Enterovirus A71)
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in two fab bind conformation
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8jiz
Q-score: 0.335
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ Pubmed: 39227720 DOI: doi:10.1038/s41594-024-01387-3 ]
- Fab5f6 heavy chain (27 kDa, Protein from Homo sapiens)
- Cryo-em structure of glun1-2a nmdar in complex with human fab23 (Cell from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
- Fab5f6 light chain (25 kDa, Protein from Homo sapiens)
Cryo-EM structure of GluN1-2A NMDAR in complex with human Fab5F6 in one fab bind conformation
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 8jj0
Q-score: 0.25
Wang H, Xie C, Deng B, Ding J, Li N, Kou Z, Jin M, He J, Wang Q, Wen H, Zhang J, Zhou Q, Chen S, Chen X, Yuan TF, Zhu S
Nat Struct Mol Biol (2024) 31 pp. 1987-1996 [ Pubmed: 39227720 DOI: doi:10.1038/s41594-024-01387-3 ]
- Fab5f6 heavy chain (27 kDa, Protein from Homo sapiens)
- Cryo-em structure of glun1-2a nmdar in complex with human fab23 (Cell from Homo sapiens)
- Glutamate receptor ionotropic, nmda 1 (95 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glutamate receptor ionotropic, nmda 2a (94 kDa, Protein from Homo sapiens)
- Fab5f6 light chain (25 kDa, Protein from Homo sapiens)