Cryo-EM structure of noradrenaline transporter in apo state
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wtu
Q-score: 0.614
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
Cryo-EM structure of noradrenaline transporter in complex with noradrenaline
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8wtv
Q-score: 0.655
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- Noradrenaline (170 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Water (18 Da, Ligand)
Cryo-EM structure of noradrenaline transporter in complex with a x-MrlA analogue
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8wtw
Q-score: 0.617
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- Apo (Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Mrla (1 kDa, Protein from Conus marmoreus)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of noradrenaline transporter in complex with bupropion
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8wtx
Q-score: 0.58
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- (2~{r})-2-(~{tert}-butylamino)-1-(3-chlorophenyl)propan-1-one (239 Da, Ligand)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
Cryo-EM structure of noradrenaline transporter in complex with ziprasidone
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8wty
Q-score: 0.549
Hu T, Yu Z, Zhao J, Meng Y, Salomon K, Bai Q, Wei Y, Zhang J, Xu S, Dai Q, Yu R, Yang B, Loland CJ, Zhao Y
Nature (2024) 632 pp. 930-937 [ DOI: doi:10.1038/s41586-024-07638-z Pubmed: 39085602 ]
- Ziprasidone (412 Da, Ligand)
- Structure of a protein (63 MDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (63 kDa, Protein from Homo sapiens)
SARS-CoV-2 Omicron spike in complex with 5817 Fab
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8khc
Q-score: 0.351
Wang Y, Zhang Z, Yang M, Xiong X, Yan Q, Cao L, Wei P, Zhang Y, Zhang L, Lv K, Chen J, Liu X, Zhao X, Xiao J, Zhang S, Zhu A, Gan M, Zhang J, Cai R, Zhuo J, Zhang Y, Rao H, Qu B, Zhang Y, Chen L, Dai J, Cheng L, Hu Q, Chen Y, Lv H, So RTY, Peiris M, Zhao J, Liu X, Mok CKP, Wang X, Zhao J
Cell Rep (2024) 43 pp. 113653-113653 [ Pubmed: 38175758 DOI: doi:10.1016/j.celrep.2023.113653 ]
- Light chain of 5817 fab (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of 5817 fab (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 omicron spike in complex with 5817 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Water (18 Da, Ligand)
The interface structure of Omicron RBD binding to 5817 Fab
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8khd
Q-score: 0.393
Wang Y, Zhang Z, Yang M, Xiong X, Yan Q, Cao L, Wei P, Zhang Y, Zhang L, Lv K, Chen J, Liu X, Zhao X, Xiao J, Zhang S, Zhu A, Gan M, Zhang J, Cai R, Zhuo J, Zhang Y, Rao H, Qu B, Zhang Y, Chen L, Dai J, Cheng L, Hu Q, Chen Y, Lv H, So RTY, Peiris M, Zhao J, Liu X, Mok CKP, Wang X, Zhao J
Cell Rep (2024) 43 pp. 113653-113653 [ Pubmed: 38175758 DOI: doi:10.1016/j.celrep.2023.113653 ]
- Light chain of 5817 (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- The interface structure of omicron rbd binding to 5817 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike protein s1 (22 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Heavy chain of 5817 (13 kDa, Protein from Homo sapiens)
Cryo-EM structure of the GPR34 receptor in complex with the antagonist YL-365
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8iyx
Q-score: 0.448
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S
PNAS (2023) 120 pp. e2308435120-e2308435120 [ Pubmed: 37733739 DOI: doi:10.1073/pnas.2308435120 ]
- 1-[4-(3-chlorophenyl)phenyl]carbonyl-4-[2-(4-phenylmethoxyphenyl)ethanoylamino]piperidine-4-carboxylic acid (583 Da, Ligand)
- Probable g-protein coupled receptor 34,probable g-protein coupled receptor 34,yl-365 (66 kDa, Protein from Homo sapiens)
- Cryo-em structure of the gpr34 receptor in complex with the antagonist yl-365 (Complex from Homo sapiens)
Cryo-EM structure of GPR34-Gi complex
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8sai
Q-score: 0.471
Xia A, Yong X, Zhang C, Lin G, Jia G, Zhao C, Wang X, Hao Y, Wang Y, Zhou P, Yang X, Deng Y, Wu C, Chen Y, Zhu J, Tang X, Liu J, Zhang S, Zhang J, Xu Z, Hu Q, Zhao J, Yue Y, Yan W, Su Z, Wei Y, Zhou R, Dong H, Shao Z, Yang S
PNAS (2023) 120 pp. e2308435120-e2308435120 [ Pubmed: 37733739 DOI: doi:10.1073/pnas.2308435120 ]
- Scfv16 (Complex from Mus musculus)
- Human gpr34 in complex with gi heterotrimer and scfv16 (Complex)
- O-[(s)-hydroxy{[(2s)-2-hydroxy-3-(octadec-9-enoyloxy)propyl]oxy}phosphoryl]-l-serine (523 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Probable g-protein coupled receptor 34 (53 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
- Soluble cytochrome b562,probable g-protein coupled receptor 34, guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, guanine nucleotide-binding protein g(i) subunit alpha-1, guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
Cryo-EM structure of the marine siphophage vB_Dshs-R4C capsid
Resolution: 3.63 Å
EM Method: Single-particle
Fitted PDBs: 8gta
Q-score: 0.475