Small molecule agonist (PCO371) bound to human parathyroid hormone receptor type 1 (PTH1R)
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 8jr9
Q-score: 0.521
Zhao LH, He Q, Yuan Q, Gu Y, He X, Shan H, Li J, Wang K, Li Y, Hu W, Wu K, Shen J, Xu HE
Nature (2023) 621 pp. 635-641 [ Pubmed: 37524305 DOI: doi:10.1038/s41586-023-06467-w ]
- A conserved and druggable pocket in class b g protein coupled receptors for 2 orally active small molecule agonists (160 kDa, Complex from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha-1 (41 kDa, Protein from Homo sapiens)
- Pco-371 (635 Da, Ligand)
Molecular recognition of two endogenous hormones by the human parathyroid hormone receptor-1
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 8ha0
Q-score: 0.485
Zhao LH, Yuan QN, Dai AT, He XH, Chen CW, Zhang C, Xu YW, Zhou Y, Wang MW, Yang DH, Xu HE
Acta Pharmacol.Sin. (2023) 44 pp. 1227-1237 [ DOI: doi:10.1038/s41401-022-01032-z Pubmed: 36482086 ]
- Nanobody 35 (15 kDa, Protein from synthetic construct)
- Palmitic acid (256 Da, Ligand)
- Pth-pthr g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Parathyroid hormone/parathyroid hormone-related peptide receptor (54 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha (41 kDa, Protein from Bos taurus)
- Cholesterol (386 Da, Ligand)
- Parathyroid hormone (4 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (43 kDa, Protein from Rattus norvegicus)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 6pb1
Q-score: 0.47
Ma S, Shen Q, Zhao LH, Mao C, Zhou XE, Shen DD, de Waal PW, Bi P, Li C, Jiang Y, Wang MW, Sexton PM, Wootten D, Melcher K, Zhang Y, Xu HE
Mol Cell (2020) 77 pp. 669- [ DOI: doi:10.1016/j.molcel.2020.01.013 Pubmed: 32004470 ]
- Nanobody 35 (15 kDa, Protein from synthetic construct)
- Urocortin 1-bound corticotropin-releasing factor 2 receptor in complex with gs protein (Complex from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Urocortin (4 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Corticotropin-releasing factor receptor 2 (45 kDa, Protein from Homo sapiens)