human NaS1 intermediate state 2
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8y5w
Q-score: 0.579
Chen X, Zhang Y, Yin J, Liu C, Xie M, Wang Y, Chen M, Zhang R, Yuan X, Li D, Chen X, Gao X, Cai G, Zhang S, Zhou B, Yang M
Sci Adv (2024) 10 pp. eado6778-eado6778 [ Pubmed: 39576865 DOI: doi:10.1126/sciadv.ado6778 ]
- Solute carrier family 13 member 1 (66 kDa, Protein from Homo sapiens)
- Sulfate ion (96 Da, Ligand)
- Membrane sodium anion transproter 2 (Complex from Homo sapiens)
- Sodium ion (22 Da, Ligand)
human NaS1 intermediate state 3
Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8y5x
Q-score: 0.484
Chen X, Zhang Y, Yin J, Liu C, Xie M, Wang Y, Chen M, Zhang R, Yuan X, Li D, Chen X, Gao X, Cai G, Zhang S, Zhou B, Yang M
Sci Adv (2024) 10 pp. eado6778-eado6778 [ Pubmed: 39576865 DOI: doi:10.1126/sciadv.ado6778 ]
- Membrane sodium anion transproter 3 (Cellular component from Homo sapiens)
- Solute carrier family 13 member 1 (66 kDa, Protein from Homo sapiens)
- Sulfate ion (96 Da, Ligand)
- Sodium ion (22 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8y5y
Q-score: 0.443
Chen X, Zhang Y, Yin J, Liu C, Xie M, Wang Y, Chen M, Zhang R, Yuan X, Li D, Chen X, Gao X, Cai G, Zhang S, Zhou B, Yang M
Sci Adv (2024) 10 pp. eado6778-eado6778 [ Pubmed: 39576865 DOI: doi:10.1126/sciadv.ado6778 ]
- Solute carrier family 13 member 1 (66 kDa, Protein from Homo sapiens)
- Membrane sodium anion transproter out (Complex from Homo sapiens)
- Sulfate ion (96 Da, Ligand)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8y5z
Q-score: 0.474
Chen X, Zhang Y, Yin J, Liu C, Xie M, Wang Y, Chen M, Zhang R, Yuan X, Li D, Chen X, Gao X, Cai G, Zhang S, Zhou B, Yang M
Sci Adv (2024) 10 pp. eado6778-eado6778 [ Pubmed: 39576865 DOI: doi:10.1126/sciadv.ado6778 ]
- Solute carrier family 13 member 1 (66 kDa, Protein from Homo sapiens)
- Sulfate ion (96 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Membrane sodium anion transproter in (Complex from Homo sapiens)
Cryo-EM co-structure of AcrB with the CU032 efflux pump inhibitor
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 9bfh
Q-score: 0.625
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- H6pd (Complex from Homo sapiens)
- (2s)-1-[(3r)-3-aminopyrrolidin-1-yl]-3-(3,4-dichlorophenoxy)propan-2-ol (305 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- Water (18 Da, Ligand)
Cryo-EM co-structure of AcrB with the EPM35 efflux pump inhibitor
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 9bfm
Q-score: 0.609
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- H6pd (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- (2s)-1-(3,4-dichlorophenoxy)-3-(4-{[4-(trifluoromethyl)pyrimidin-2-yl]amino}piperidin-1-yl)propan-2-ol (465 Da, Ligand)
Cryo-EM co-structure of AcrB with the CU232 efflux pump inhibitor
Resolution: 2.71 Å
EM Method: Single-particle
Fitted PDBs: 9bfn
Q-score: 0.604
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- (2r)-1-(4-aminopiperidin-1-yl)-3-[3-(trifluoromethyl)phenoxy]propan-2-ol (318 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- H6pd (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Cryo-EM co-structure of AcrB with CU244
Resolution: 2.44 Å
EM Method: Single-particle
Fitted PDBs: 9bft
Q-score: 0.658
Allgood SC, Su CC, Crooks AL, Meyer CT, Zhou B, Betterton MD, Barbachyn MR, Yu EW, Detweiler CS
mBio (2023) 14 pp. e0249223- [ DOI: doi:10.1073/pnas.1901346116 Pubmed: 37921493 ]
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli K-12)
- (2s)-1-{[(1r,5r)-3-azabicyclo[3.1.0]hexan-6-yl]amino}-3-(3,5-dichlorophenoxy)propan-2-ol (317 Da, Ligand)
- H6pd (Complex from Homo sapiens)
- Water (18 Da, Ligand)
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8jzs
Q-score: 0.521
Chen X, Xie M, Zhang S, Monguio-Tortajada M, Yin J, Liu C, Zhang Y, Delacretaz M, Song M, Wang Y, Dong L, Ding Q, Zhou B, Tian X, Deng H, Xu L, Liu X, Yang Z, Chang Q, Na J, Zeng W, Superti-Furga G, Rebsamen M, Yang M
Nat Commun (2023) 14 pp. 6627-6627 [ Pubmed: 37863913 DOI: doi:10.1038/s41467-023-42210-9 ]
- Cholesterol (386 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Endolysosomal transporter (Cellular component from Homo sapiens)
- Lysosomal transporter (66 kDa, Protein from Homo sapiens)
Cryo EM structure of lysosomal ATPase
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7fjp
Q-score: 0.527
Chen X, Zhou M, Zhang S, Yin J, Zhang P, Xuan X, Wang P, Liu Z, Zhou B, Yang M
Cell Discov (2021) 7 pp. 106-106 [ DOI: doi:10.1038/s41421-021-00334-6 Pubmed: 34728622 ]
- Phosphate ion (94 Da, Ligand)
- Polyamine-transporting atpase 13a2 (125 kDa, Protein from Homo sapiens)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Lysosomal atpase e1p_adp (Cellular component from Homo sapiens)
- Magnesium ion (24 Da, Ligand)