Cryo-EM structure of bilirubin ditaurate (BDT) bound human ABC transporter ABCC2
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8jxq
Q-score: 0.364
Mao YX, Chen ZP, Wang L, Wang J, Zhou CZ, Hou WT, Chen Y
Nat Commun (2024) 15 pp. 1061-1061 [ Pubmed: 38316776 DOI: doi:10.1038/s41467-024-45337-5 ]
- Atp-binding cassette sub-family c member 2 (176 kDa, Protein from Homo sapiens)
- Atp-binding cassette sub-family c member 2 (Cellular component from Homo sapiens)
- 2-[3-[5-[(e)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-4-methyl-3-[3-oxidanylidene-3-(2-sulfoethylamino)propyl]-1h-pyrrol-2-yl]methyl]-4-methyl-1h-pyrrol-3-yl]propanoylamino]ethanesulfonic acid (798 Da, Ligand)
- Cholesterol (386 Da, Ligand)
Cryo-EM structure of human ABC transporter ABCC2 under active turnover condition
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8jxu
Q-score: 0.349
Mao YX, Chen ZP, Wang L, Wang J, Zhou CZ, Hou WT, Chen Y
Nat Commun (2024) 15 pp. 1061-1061 [ Pubmed: 38316776 DOI: doi:10.1038/s41467-024-45337-5 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Atp-binding cassette sub-family c member 2 (Cellular component from Homo sapiens)
- Atp-binding cassette sub-family c member 2 (176 kDa, Protein from Homo sapiens)
Cryo-EM structure of dehydroepiandrosterone sulfate-bound human ABC transporter ABCC3 in nanodiscs
Cryo-EM structure of aspirin-bound ABCC4
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 8j3w
Q-score: 0.413
Chen Y, Wang L, Hou WT, Zhou CZ, Chen Y, Li Q
Nat Cardiovasc Res (2023) [ ]
- 2-(acetyloxy)benzoic acid (180 Da, Ligand)
- Apo-form abcc4 (Complex from Homo sapiens)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
Cryo-EM structure of ATP-U46619-bound ABCC4
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8j3z
Q-score: 0.455
Chen Y, Wang L, Hou WT, Zhou CZ, Chen Y, Li Q
Nat Cardiovasc Res (2023) [ ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- (5z)-7-{(1r,4s,5s,6r)-6-[(1e,3s)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid (350 Da, Ligand)
- Atp-binding cassette sub-family c member 4 (149 kDa, Protein from Homo sapiens)
- Apo-form abcc4 (Complex from Homo sapiens)
Cryo-EM structure of the human cholesterol transporter ABCG1 in complex with cholesterol
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 7fdv
Q-score: 0.528
Xu D, Li Y, Yang F, Sun CR, Pan J, Wang L, Chen ZP, Fang SC, Yao X, Hou WT, Zhou CZ, Chen Y
Cell Rep (2022) 38 pp. 110298-110298 [ DOI: doi:10.1016/j.celrep.2022.110298 Pubmed: 35081353 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- The complex of human abcg1 with cholesterol and atp (152 kDa, Complex from Homo sapiens)
- Atp-binding cassette sub-family g member 1 (75 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- [(e,2s,3r)-2-(hexadecanoylamino)-3-oxidanyl-octadec-4-enyl] 2-(trimethylazaniumyl)ethyl phosphate (703 Da, Ligand)
Cryo-EM structure of human very long-chain fatty acid ABC transporter ABCD1
Cryo-EM structure of ATP-bound human very long-chain fatty acid ABC transporter ABCD1
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7vx8
Q-score: 0.594
Chen ZP, Xu D, Wang L, Mao YX, Li Y, Cheng MT, Zhou CZ, Hou WT, Chen Y
Nat Commun (2022) 13 pp. 3299-3299 [ DOI: doi:10.1038/s41467-022-30974-5 Pubmed: 35676282 ]
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Atp-bound human peroxisomal abcd1 (175 MDa, Complex from Caenorhabditis elegans)
- Magnesium ion (24 Da, Ligand)
- Peroxisomal membrane protein related,atp-binding cassette sub-family d member 1 (87 kDa, Protein from Homo sapiens)