Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 1)
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8wqa
Q-score: 0.362
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Cryo-em structure of cul2-rbx1-elob-eloc-fem1b bound with the c-degron of ccdc89 (conformation 1) (Complex from Homo sapiens)
- Coiled-coil domain-containing protein 89 (3 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CCDC89 (conformation 2)
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8wqb
Q-score: 0.39
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Coiled-coil domain-containing protein 89 (3 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Cryo-em structure of cul2-rbx1-elob-eloc-fem1b bound with the c-degron of ccdc89 (conformation 2) (Complex from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
cryo-EM structure of neddylated CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CDK5R1
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 8wqc
Q-score: 0.352
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Cryo-em structure of neddylated cul2-rbx1-elob-eloc-fem1b bound with the c-degron of cdk5r1 (Complex from Homo sapiens)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
Local refinement of FEM1B bound with the C-degron of CCC89
Resolution: 3.55 Å
EM Method: Single-particle
Fitted PDBs: 8wqd
Q-score: 0.5
Cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 1)
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8wqe
Q-score: 0.372
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Protein casp (3 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Cryo-em structure of cul2-rbx1-elob-eloc-fem1b bound with the c-degron of cux1 (conformation 1) (Complex from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
cryo-EM structure of CUL2-RBX1-ELOB-ELOC-FEM1B bound with the C-degron of CUX1 (conformation 2)
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8wqf
Q-score: 0.439
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Protein casp (3 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Cryo-em structure of cul2-rbx1-elob-eloc-fem1b bound with the c-degron of cux1 (conformation 2) (Complex from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
Resolution: 3.44 Å
EM Method: Single-particle
Fitted PDBs: 8wqh
Q-score: 0.362
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Coiled-coil domain-containing protein 89 (3 kDa, Protein from Homo sapiens)
- Cryo-em structure of neddylated cul2-rbx1-elob-eloc-fem1b bound with the c-degron of ccdc89 (conformation 2) (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1, n-terminally processed (11 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-c (10 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
Local refinement of FEM1B bound with the C-degron of CUX1
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8wqi
Q-score: 0.47
Chen X, Raiff A, Li S, Guo Q, Zhang J, Zhou H, Timms RT, Yao X, Elledge SJ, Koren I, Zhang K, Xu C
Nat Commun (2024) 15 pp. 3558-3558 [ DOI: doi:10.1038/s41467-024-47890-5 Pubmed: 38670995 ]
- Protein casp (3 kDa, Protein from Homo sapiens)
- Local refinement of fem1b bound with the c-degron of cux1 (Complex from Homo sapiens)
- Protein fem-1 homolog b (70 kDa, Protein from Homo sapiens)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7xog
Q-score: 0.294
Tan S, Zhao J, Hu X, Li Y, Wu Z, Lu G, Yu Z, Du B, Liu Y, Li L, Chen Y, Li Y, Yao Y, Zhang X, Rao J, Gao G, Peng Y, Liu H, Yuan Z, Liu J, Wang Q, Hu H, Gao X, Zhou H, Yu H, Xu Y, Yu W, Feng L, Wang M, Shan C, Lu J, Lin J
Sci Bull (Beijing) (2023) 68 pp. 3192-3206 [ Pubmed: 37993332 DOI: doi:10.1016/j.scib.2023.11.024 ]
- Spike glycoprotein,peptide (142 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Severe acute respiratory syndrome coronavirus (Complex from Severe acute respiratory syndrome coronavirus)
- Alpha-d-mannopyranose (180 Da, Ligand)