Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 monomer state
Resolution: 4.13 Å
EM Method: Single-particle
Fitted PDBs: 8fo2
Q-score: 0.333
Zhu H, Tonelli F, Turk M, Prescott A, Alessi DR, Sun J
Science (2023) 382 pp. 1404-1411 [ DOI: doi:10.1126/science.adi9926 Pubmed: 38127736 ]
- Leucine-rich repeat serine/threonine-protein kinase 2 (286 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ras-related protein rab-7l1 (20 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Lrrk2-rab29 (Complex from Homo sapiens)
Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 dimer state
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 8fo8
Q-score: 0.264
Zhu H, Tonelli F, Turk M, Prescott A, Alessi DR, Sun J
Science (2023) 382 pp. 1404-1411 [ DOI: doi:10.1126/science.adi9926 Pubmed: 38127736 ]
- Leucine-rich repeat serine/threonine-protein kinase 2 (286 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ras-related protein rab-7l1 (20 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Rab29-lrrk2 (Complex from Homo sapiens)
Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 tetramer state
Resolution: 3.48 Å
EM Method: Single-particle
Fitted PDBs: 8fo9
Q-score: 0.307
Zhu H, Tonelli F, Turk M, Prescott A, Alessi DR, Sun J
Science (2023) 382 pp. 1404-1411 [ DOI: doi:10.1126/science.adi9926 Pubmed: 38127736 ]
- Leucine-rich repeat serine/threonine-protein kinase 2 (286 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ras-related protein rab-7l1 (20 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Rab29-lrrk2 (Complex from Homo sapiens)
Cryo-EM structure of LRRK2 bound with type-I inhibitor DNL201
Resolution: 4.02 Å
EM Method: Single-particle
Fitted PDBs: 8smc
Q-score: 0.435
Zhu H, Tonelli F, Turk M, Prescott A, Alessi DR, Sun J
Science (2023) 382 pp. 1404-1411 [ DOI: doi:10.1126/science.adi9926 Pubmed: 38127736 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Lrrk2 (Complex from Homo sapiens)
- Non-specific serine/threonine protein kinase (136 kDa, Protein from Homo sapiens)
- 2-methyl-2-(3-methyl-4-{[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1h-pyrazol-1-yl)propanenitrile (339 Da, Ligand)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7yrg
Q-score: 0.227
Huang L, Wang Y, Long H, Zhu H, Wen Z, Zhang L, Zhang W, Guo Z, Wang L, Tang F, Hu J, Bao K, Zhu P, Li G, Zhou Z
Mol Cell (2023) 83 pp. 2884-2895.e7 [ Pubmed: 37536340 DOI: doi:10.1016/j.molcel.2023.07.001 ]
- Histone,suv420h1 (Complex from Xenopus laevis)
- Histone h2b 1.1 (10 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Histone methyltransferase and nucleosome complex (Complex)
- Histone h2a.z (12 kDa, Protein from Homo sapiens)
- Dna (146-mer) (45 kDa, DNA from Homo sapiens)
- Histone h3.2 (12 kDa, Protein from Xenopus laevis)
- S-adenosylmethionine (398 Da, Ligand)
- [histone h4]-n-methyl-l-lysine20 n-methyltransferase kmt5b (32 kDa, Protein from Homo sapiens)
- Histone (Complex from Homo sapiens)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7yrd
Q-score: 0.484
Huang L, Wang Y, Long H, Zhu H, Wen Z, Zhang L, Zhang W, Guo Z, Wang L, Tang F, Hu J, Bao K, Zhu P, Li G, Zhou Z
Mol Cell (2023) 83 pp. 2884-2895.e7 [ Pubmed: 37536340 DOI: doi:10.1016/j.molcel.2023.07.001 ]
- Histone h2b 1.1 (10 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Histone h2a.z (12 kDa, Protein from Homo sapiens)
- Dna (146-mer) (45 kDa, DNA from Homo sapiens)
- Histone h3.2 (12 kDa, Protein from Xenopus laevis)
- S-adenosylmethionine (398 Da, Ligand)
- Histone methyltransferase and nucleosome complex (Complex from Homo sapiens)
- [histone h4]-n-methyl-l-lysine20 n-methyltransferase kmt5b (32 kDa, Protein from Homo sapiens)
Cryo-EM structure of the HCMV pentamer bound by Fabs 2-18 and 8I21
Resolution: 4.02 Å
EM Method: Single-particle
Fitted PDBs: 7kbb
Q-score: 0.274
Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
Sci Adv (2022) 8 pp. eabm2546-eabm2546 [ Pubmed: 35275718 DOI: doi:10.1126/sciadv.abm2546 ]
- 8i21 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Ul131a (13 kDa, Protein from Human cytomegalovirus)
- Hcmv pentamer (refinement focused on three of the subunits) (Complex from Human betaherpesvirus 5)
- Fab 2-18 (Complex from Homo sapiens)
- Envelope glycoprotein ul130 (21 kDa, Protein from Human cytomegalovirus)
- Fab 8i21 (Complex from Homo sapiens)
- 8i21 fab light chain (23 kDa, Protein from Homo sapiens)
- Hcmv pentamer bound by antibodies 2-18 and 8i21 (280 kDa, Complex)
- Envelope protein ul128 (16 kDa, Protein from Human cytomegalovirus)
- 2-18 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-18 fab heavy chain (25 kDa, Protein from Homo sapiens)
Cryo-EM structure of the HCMV pentamer bound by human neuropilin 2
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 7m22
Q-score: 0.409
Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
Sci Adv (2022) 8 pp. eabm2546-eabm2546 [ Pubmed: 35275718 DOI: doi:10.1126/sciadv.abm2546 ]
- Neuropilin-2 (65 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ul131a (13 kDa, Protein from Human cytomegalovirus)
- The ectodomain of the hcmv pentamer (Complex from Human betaherpesvirus 5)
- The ectodomain of the hcmv pentamer bound by domains a1a2b1b2 of human neuropilin 2 (230 kDa, Complex)
- Envelope glycoprotein ul130 (21 kDa, Protein from Human cytomegalovirus)
- Envelope protein ul128 (16 kDa, Protein from Human cytomegalovirus)
- Domains a1a2b1b2 of human neuropilin 2 (Complex from Homo sapiens)