Structure of HKU1B RBD with TMPRSS2
Gao X, Zhu K, Wang L, Shang K, Hua L, Qin B, Zhu H, Ding W, Cui S
Cell Discov (2024) 10 pp. 84-84 [ DOI: doi:10.1038/s41421-024-00717-5 Pubmed: 39112468 ]
- Hku1b-rbd with tmprss2 receptor (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike protein s1 (31 kDa, Protein from Candidatus Accumulibacter adiacens)
- Transmembrane protease serine 2 (42 kDa, Protein from Homo sapiens)
Structure of the wild-type Arabidopsis ABCB19 in the brassinolide and AMP-PNP bound state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8woo
Q-score: 0.401
Ying W, Wang Y, Wei H, Luo Y, Ma Q, Zhu H, Janssens H, Vukasinovic N, Kvasnica M, Winne JM, Gao Y, Tan S, Friml J, Liu X, Russinova E, Sun L
Science (2024) 383 pp. eadj4591-eadj4591 [ DOI: doi:10.1126/science.adj4591 Pubmed: 38513023 ]
- Abc transporter b family member 19 (136 kDa, Protein from Arabidopsis thaliana)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Purified wild-type abcb19 protein in complex with brassinolide and amp-pnp (Cellular component from Arabidopsis thaliana)
- Brassinolide (480 Da, Ligand)
Structure of the Arabidopsis E529Q/E1174Q ABCB19 in the ATP bound state
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8wp0
Q-score: 0.464
Ying W, Wang Y, Wei H, Luo Y, Ma Q, Zhu H, Janssens H, Vukasinovic N, Kvasnica M, Winne JM, Gao Y, Tan S, Friml J, Liu X, Russinova E, Sun L
Science (2024) 383 pp. eadj4591-eadj4591 [ DOI: doi:10.1126/science.adj4591 Pubmed: 38513023 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Abc transporter b family member 19 (136 kDa, Protein from Arabidopsis thaliana)
- Purified e529q/e1174q mutant abcb19 protein in complex with atp (Cellular component from Arabidopsis thaliana)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8foi
Q-score: 0.564
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Native gabaa receptor isolated from mouse brain containing two alpha1 subunits, in complex with 8e3-fab, gaba, and allopregnanolone (350 kDa, Complex from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Light chain of 8e3-fab (23 kDa, Protein from Mus musculus)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- N-octane (114 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8g4n
Q-score: 0.543
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Light chain of 8e3 fab (23 kDa, Protein from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Dodecane (170 Da, Ligand)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- N-octane (114 Da, Ligand)
- Zolpidem (307 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Native gabaa receptor isolated from mouse brain containing two alpha1 subunits, in complex with 8e3-fab, gaba, zolpidem, and endogenous neurosteroid (350 kDa, Complex from Mus musculus)
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 8g4o
Q-score: 0.423
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Light chain of 8e3 fab (23 kDa, Protein from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- Native gabaa receptor isolated from mouse brain containing two alpha1 subunits, in complex with 8e3-fab, didesethylflurazepam, and endogenous gaba (350 kDa, Complex from Mus musculus)
- (5m)-1-(2-aminoethyl)-7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2h-1,4-benzodiazepin-2-one (331 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.56 Å
EM Method: Single-particle
Fitted PDBs: 8g4x
Q-score: 0.504
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Light chain of 8e3 fab (23 kDa, Protein from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-3 (55 kDa, Protein from Mus musculus)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Native gabaa receptor isolated from mouse brain containing one alpha1 subunit, in complex with 8e3-fab, gaba, and allopregnanolone (350 kDa, Complex from Mus musculus)
Resolution: 2.64 Å
EM Method: Single-particle
Fitted PDBs: 8g5f
Q-score: 0.491
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Light chain of 8e3 fab (23 kDa, Protein from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-3 (55 kDa, Protein from Mus musculus)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- Native gabaa receptor isolated from mouse brain containing one alpha1 subunit, in complex with 8e3-fab, gaba, and allopregnanolone (350 kDa, Complex from Mus musculus)
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 8g5g
Q-score: 0.435
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Light chain of 8e3 fab (23 kDa, Protein from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-3 (55 kDa, Protein from Mus musculus)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- Zolpidem (307 Da, Ligand)
- Native gabaa receptor isolated from mouse brain containing one alpha1 subunit, in complex with 8e3-fab, gaba, zolpidem, and endogenous neurosteroid (350 kDa, Complex from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)
Resolution: 2.89 Å
EM Method: Single-particle
Fitted PDBs: 8g5h
Q-score: 0.477
Sun C, Zhu H, Clark S, Gouaux E
Nature (2023) 622 pp. 195-201 [ Pubmed: 37730991 DOI: doi:10.1038/s41586-023-06556-w ]
- Light chain of 8e3 fab (23 kDa, Protein from Mus musculus)
- Heavy chain of 8e3 fab (24 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-3 (55 kDa, Protein from Mus musculus)
- Allopregnanolone (318 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit gamma-2 (55 kDa, Protein from Mus musculus)
- Gamma-aminobutyric acid receptor subunit alpha-1 (51 kDa, Protein from Mus musculus)
- Zolpidem (307 Da, Ligand)
- Native gabaa receptor isolated from mouse brain containing one alpha1 subunit, in complex with 8e3-fab, gaba, zolpidem, and endogenous neurosteroid (350 kDa, Complex from Mus musculus)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- Gamma-aminobutyric acid receptor subunit beta-2 (59 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- [(2r)-2-octanoyloxy-3-[oxidanyl-[(1r,2r,3s,4r,5r,6s)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate (746 Da, Ligand)