Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 monomer state
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8vh4
Q-score: 0.333
Li X, Zhu H, Huang BT, Li X, Kim H, Tan H, Zhang Y, Choi I, Peng J, Xu P, Sun J, Yue Z
Nat Commun (2024) 15 pp. 8434-8434 [ Pubmed: 39343966 DOI: doi:10.1038/s41467-024-52723-6 ]
- Leucine-rich repeat serine/threonine-protein kinase 2 (286 kDa, Protein from Homo sapiens)
- Rab12-lrrk2 (Complex from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ras-related protein rab-12 (20 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
Cryo-EM structure of Rab12-LRRK2 complex in the LRRK2 dimer state
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8vh5
Q-score: 0.248
Li X, Zhu H, Huang BT, Li X, Kim H, Tan H, Zhang Y, Choi I, Peng J, Xu P, Sun J, Yue Z
Nat Commun (2024) 15 pp. 8434-8434 [ Pubmed: 39343966 DOI: doi:10.1038/s41467-024-52723-6 ]
- Leucine-rich repeat serine/threonine-protein kinase 2 (286 kDa, Protein from Homo sapiens)
- Rab12-lrrk2 (Complex from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ras-related protein rab-12 (20 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
SARS-CoV-2 spike protein in complex with a trivalent nanobody
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8w4f
Q-score: 0.093
Cryo-EM structure of Rab29-LRRK2 complex in the LRRK2 monomer state
Resolution: 4.13 Å
EM Method: Single-particle
Fitted PDBs: 8fo2
Q-score: 0.333
Zhu H, Tonelli F, Turk M, Prescott A, Alessi DR, Sun J
Science (2023) 382 pp. 1404-1411 [ DOI: doi:10.1126/science.adi9926 Pubmed: 38127736 ]
- Leucine-rich repeat serine/threonine-protein kinase 2 (286 kDa, Protein from Homo sapiens)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Ras-related protein rab-7l1 (20 kDa, Protein from Homo sapiens)
- Phosphoaminophosphonic acid-guanylate ester (522 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Lrrk2-rab29 (Complex from Homo sapiens)
Cryo-EM structure of LRRK2 bound with type-I inhibitor DNL201
Resolution: 4.02 Å
EM Method: Single-particle
Fitted PDBs: 8smc
Q-score: 0.435
Zhu H, Tonelli F, Turk M, Prescott A, Alessi DR, Sun J
Science (2023) 382 pp. 1404-1411 [ DOI: doi:10.1126/science.adi9926 Pubmed: 38127736 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Lrrk2 (Complex from Homo sapiens)
- Non-specific serine/threonine protein kinase (136 kDa, Protein from Homo sapiens)
- 2-methyl-2-(3-methyl-4-{[4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-1h-pyrazol-1-yl)propanenitrile (339 Da, Ligand)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7yrg
Q-score: 0.227
Huang L, Wang Y, Long H, Zhu H, Wen Z, Zhang L, Zhang W, Guo Z, Wang L, Tang F, Hu J, Bao K, Zhu P, Li G, Zhou Z
Mol Cell (2023) 83 pp. 2884-2895.e7 [ Pubmed: 37536340 DOI: doi:10.1016/j.molcel.2023.07.001 ]
- Histone,suv420h1 (Complex from Xenopus laevis)
- Histone h2b 1.1 (10 kDa, Protein from Xenopus laevis)
- Zinc ion (65 Da, Ligand)
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Histone methyltransferase and nucleosome complex (Complex)
- Histone h2a.z (12 kDa, Protein from Homo sapiens)
- Dna (146-mer) (45 kDa, DNA from Homo sapiens)
- Histone h3.2 (12 kDa, Protein from Xenopus laevis)
- S-adenosylmethionine (398 Da, Ligand)
- [histone h4]-n-methyl-l-lysine20 n-methyltransferase kmt5b (32 kDa, Protein from Homo sapiens)
- Histone (Complex from Homo sapiens)
Cryo-EM structure of SaCas9-sgRNA-DNA ternary complex
Du W, Zhu H, Qian J, Xue D, Zheng S, Huang Q
Int J Mol Sci (2023) 24 [ DOI: doi:10.3390/ijms24021204 Pubmed: 36674715 ]
- Single-guide rna (sgrna) (RNA from synthetic construct)
- Sacas9 (Complex)
- Target dna strand(ts) (DNA from synthetic construct)
- Non-target dna strand (nts) (DNA from synthetic construct)
- Sacas9 (Protein from Staphylococcus aureus)
- Sacas9-sgrna-target dna ternary complex (Complex from Staphylococcus aureus)
- Sgrna-target dna (Complex)
Human IFT-A complex structures provide molecular insights into ciliary transport
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 8fh3
Q-score: 0.248
Jiang M, Palicharla VR, Miller D, Hwang SH, Zhu H, Hixson P, Mukhopadhyay S, Sun J
Cell Res (2023) 33 pp. 288-298 [ DOI: doi:10.1038/s41422-023-00778-3 Pubmed: 36775821 ]
- Zinc ion (65 Da, Ligand)
- Wd repeat-containing protein 19 (151 kDa, Protein from Homo sapiens)
- Ift-a_tulp3 (Complex from Homo sapiens)
- Intraflagellar transport complex a (ift-a) (Complex from Homo sapiens)
- Intraflagellar transport protein 122 homolog (141 kDa, Protein from Homo sapiens)
- Intraflagellar transport protein 140 homolog (165 kDa, Protein from Homo sapiens)
- Wd repeat-containing protein 35 (133 kDa, Protein from Homo sapiens)
- Tubby-related protein 3 (49 kDa, Protein from Homo sapiens)
One RBD-up 2 of pre-fusion SARS-CoV-2 Gamma variant spike protein
Resolution: 4.4 Å
EM Method: Single-particle
Fitted PDBs: 7sbt
Q-score: 0.269
Zhang J, Xiao T, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Walsh Jr RM, Rits-Volloch S, Wesemann DR, Yang W, Seaman MS, Lu J, Chen B
Science (2021) 374 pp. 1353-1360 [ DOI: doi:10.1126/science.abl9463 Pubmed: 34698504 ]
One RBD-up 2 of pre-fusion SARS-CoV-2 Delta variant spike protein
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7sbo
Q-score: 0.266
Zhang J, Xiao T, Cai Y, Lavine CL, Peng H, Zhu H, Anand K, Tong P, Gautam A, Mayer ML, Walsh Jr RM, Rits-Volloch S, Wesemann DR, Yang W, Seaman MS, Lu J, Chen B
Science (2021) 374 pp. 1353-1360 [ DOI: doi:10.1126/science.abl9463 Pubmed: 34698504 ]