Cryo-EM structure of the HCMV pentamer bound by human neuropilin 2
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 7m22
Q-score: 0.409
Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
Sci Adv (2022) 8 pp. eabm2546-eabm2546 [ Pubmed: 35275718 DOI: doi:10.1126/sciadv.abm2546 ]
- Domains a1a2b1b2 of human neuropilin 2 (Complex from Homo sapiens)
- Envelope glycoprotein ul130 (21 kDa, Protein from Human cytomegalovirus)
- Envelope protein ul128 (16 kDa, Protein from Human cytomegalovirus)
- Ul131a (13 kDa, Protein from Human cytomegalovirus)
- The ectodomain of the hcmv pentamer (Complex from Human betaherpesvirus 5)
- The ectodomain of the hcmv pentamer bound by domains a1a2b1b2 of human neuropilin 2 (230 kDa, Complex)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neuropilin-2 (65 kDa, Protein from Homo sapiens)
Cryo-EM structure of the HCMV pentamer bound by antibodies 1-103, 1-32 and 2-25
Resolution: 3.81 Å
EM Method: Single-particle
Fitted PDBs: 7m30
Q-score: 0.323
Wrapp D, Ye X, Ku Z, Su H, Jones HG, Wang N, Mishra AK, Freed DC, Li F, Tang A, Li L, Jaijyan DK, Zhu H, Wang D, Fu TM, Zhang N, An Z, McLellan JS
Sci Adv (2022) 8 pp. eabm2546-eabm2546 [ Pubmed: 35275718 DOI: doi:10.1126/sciadv.abm2546 ]
- Quaternary complex of the hcmv pentamer bound by fabs 1-103, 1-32, and 2-25 (310 kDa, Complex)
- 2-25 fab (Complex from Homo sapiens)
- 1-103 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 1-103 fab light chain (22 kDa, Protein from Homo sapiens)
- 1-103 fab (Complex from Homo sapiens)
- 1-32 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein ul130 (21 kDa, Protein from Human cytomegalovirus)
- 2-25 fab light chain (22 kDa, Protein from Homo sapiens)
- Hcmv pentamer (Complex from Human betaherpesvirus 5)
- 2-25 fab heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope protein ul128 (16 kDa, Protein from Human cytomegalovirus)
- Ul131a (13 kDa, Protein from Human cytomegalovirus)
- 1-32 fab heavy chain (26 kDa, Protein from Homo sapiens)
- Envelope glycoprotein l (27 kDa, Protein from Human cytomegalovirus)
- 1-32 fab (Complex from Homo sapiens)
Structural impact on SARS-CoV-2 spike protein by D614G substitution
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7krq
Q-score: 0.415
Zhang J, Cai Y, Xiao T, Lu J, Peng H, Sterling SM, Walsh Jr RM, Rits-Volloch S, Zhu H, Woosley AN, Yang W, Sliz P, Chen B
Science (2021) 372 pp. 525-530 [ DOI: doi:10.1126/science.abf2303 Pubmed: 33727252 ]
Structural impact on SARS-CoV-2 spike protein by D614G substitution
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7krr
Q-score: 0.401
Zhang J, Cai Y, Xiao T, Lu J, Peng H, Sterling SM, Walsh Jr RM, Rits-Volloch S, Zhu H, Woosley AN, Yang W, Sliz P, Chen B
Science (2021) 372 pp. 525-530 [ DOI: doi:10.1126/science.abf2303 Pubmed: 33727252 ]
- Open state( one rbd up) of pre-fusion sars-cov-2 d614g mutant spike glycoprotein (440 MDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structural impact on SARS-CoV-2 spike protein by D614G substitution
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7krs
Q-score: 0.415
Zhang J, Cai Y, Xiao T, Lu J, Peng H, Sterling SM, Walsh Jr RM, Rits-Volloch S, Zhu H, Woosley AN, Yang W, Sliz P, Chen B
Science (2021) 372 pp. 525-530 [ DOI: doi:10.1126/science.abf2303 Pubmed: 33727252 ]