Structure of Src in complex with beta-arrestin 1 revealing SH3 binding sites
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9bt8
Q-score: 0.539
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Proto-oncogene tyrosine-protein kinase src (54 kDa, Protein from Gallus gallus)
- Antibody fragment fab30, light chain (23 kDa, Protein from Bacteriophage sp.)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Bacteriophage sp.)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Nanobody 32 (13 kDa, Protein from Lama glama)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment fab30 in complex with three-domain src (sh3-sh2-sh1). (Complex from Rattus norvegicus)
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
Structure of SH3 domain of Src in complex with beta-arrestin 1
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 9cx3
Q-score: 0.423
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Antibody fragment fab30, light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment fab30 in complex with sh3 domain of src (Complex from Rattus norvegicus)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Mus musculus)
- Proto-oncogene tyrosine-protein kinase src (9 kDa, Protein from Gallus gallus)
- Nanobody 32 (13 kDa, Protein from Lama glama)
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
Structure of SH3 domain of Src in complex with beta-arrestin 1
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9cx9
Q-score: 0.47
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Antibody fragment fab30, light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide and antibody fragment fab30 in complex with sh3 domain of src (Complex from Rattus norvegicus)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Mus musculus)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Proto-oncogene tyrosine-protein kinase src (9 kDa, Protein from Gallus gallus)
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 7zqs
Q-score: 0.6
Cheng EL, Cardle II, Kacherovsky N, Bansia H, Wang T, Zhou Y, Raman J, Yen A, Gutierrez D, Salipante SJ, des Georges A, Jensen MC, Pun SH
J Am Chem Soc (2022) 144 pp. 13851-13864 [ Pubmed: 35875870 DOI: doi:10.1021/jacs.2c05349 ]
- Transferrin receptor protein 1 (84 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Human transferrin receptor 1 in complex with dna aptamer (190 kDa, Complex from Homo sapiens)
- Dna (30-mer) (15 kDa, DNA from unidentified)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)