Structure of Src in complex with beta-arrestin 1 revealing SH3 binding sites
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9bt8
Q-score: 0.539
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Proto-oncogene tyrosine-protein kinase src (54 kDa, Protein from Gallus gallus)
- Antibody fragment fab30, light chain (23 kDa, Protein from Bacteriophage sp.)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Bacteriophage sp.)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Nanobody 32 (13 kDa, Protein from Lama glama)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment fab30 in complex with three-domain src (sh3-sh2-sh1). (Complex from Rattus norvegicus)
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
Structure of SH3 domain of Src in complex with beta-arrestin 1
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 9cx3
Q-score: 0.423
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Antibody fragment fab30, light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment fab30 in complex with sh3 domain of src (Complex from Rattus norvegicus)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Mus musculus)
- Proto-oncogene tyrosine-protein kinase src (9 kDa, Protein from Gallus gallus)
- Nanobody 32 (13 kDa, Protein from Lama glama)
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
Structure of SH3 domain of Src in complex with beta-arrestin 1
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9cx9
Q-score: 0.47
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Antibody fragment fab30, light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide and antibody fragment fab30 in complex with sh3 domain of src (Complex from Rattus norvegicus)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Mus musculus)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Proto-oncogene tyrosine-protein kinase src (9 kDa, Protein from Gallus gallus)
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 7zqs
Q-score: 0.6
Cheng EL, Cardle II, Kacherovsky N, Bansia H, Wang T, Zhou Y, Raman J, Yen A, Gutierrez D, Salipante SJ, des Georges A, Jensen MC, Pun SH
J Am Chem Soc (2022) 144 pp. 13851-13864 [ Pubmed: 35875870 DOI: doi:10.1021/jacs.2c05349 ]
- Transferrin receptor protein 1 (84 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Human transferrin receptor 1 in complex with dna aptamer (190 kDa, Complex from Homo sapiens)
- Dna (30-mer) (15 kDa, DNA from unidentified)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Multidrug efflux pump subunit AcrB
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7rr6
Q-score: 0.52
Trinh TKH, Cabezas AJ, Joshi S, Catalano C, Siddique AB, Qiu W, Deshmukh S, des Georges A, Guo Y
Chem Sci (2023) 14 pp. 7310-7326 [ DOI: doi:10.1039/d3sc01890c Pubmed: 37416719 ]
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Dodecane (170 Da, Ligand)
- Multidrug efflux pump subunit acrb (Complex from Escherichia coli (strain K12))
- Phosphatidylethanolamine (734 Da, Ligand)
Multidrug efflux pump subunit AcrB
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7rr7
Q-score: 0.517
Trinh TKH, Cabezas AJ, Joshi S, Catalano C, Siddique AB, Qiu W, Deshmukh S, des Georges A, Guo Y
Chem Sci (2023) 14 pp. 7310-7326 [ DOI: doi:10.1039/d3sc01890c Pubmed: 37416719 ]
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Dodecane (170 Da, Ligand)
- Multidrug efflux pump subunit acrb (Complex from Escherichia coli (strain K12))
- Phosphatidylethanolamine (734 Da, Ligand)
Multidrug efflux pump subunit AcrB
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 7rr8
Q-score: 0.547
Trinh TKH, Cabezas AJ, Joshi S, Catalano C, Siddique AB, Qiu W, Deshmukh S, des Georges A, Guo Y
Chem Sci (2023) 14 pp. 7310-7326 [ DOI: doi:10.1039/d3sc01890c Pubmed: 37416719 ]
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Dodecane (170 Da, Ligand)
- Multidrug efflux pump subunit acrb (Complex from Escherichia coli (strain K12))
- Phosphatidylethanolamine (734 Da, Ligand)
Small conductance mechanosensitive channel MscS
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7raz
Q-score: 0.418
Catalano C, Ben-Hail D, Qiu W, des Georges A, Guo Y
To Be Published
Low conductance mechanosensitive channel YnaI
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7n4t
Q-score: 0.557
Catalano C, Ben-Hail D, Qiu W, Blount P, des Georges A, Guo Y
Membranes (Basel) (2021) 11 [ DOI: doi:10.3390/membranes11110849 Pubmed: 34832078 ]
Functional Pathways of Biomolecules Retrieved from Single-particle Snapshots
Resolution: 4.5 Å
EM Method: Single-particle
Fitted PDBs: 6pv6
Q-score: 0.18
Dashti A, Mashayekhi G, Shekhar M, Ben Hail D, Salah S, Schwander P, des Georges A, Singharoy A, Frank J, Ourmazd A
Nat Commun (2020) 11 pp. 4734-4734 [ DOI: doi:10.1038/s41467-020-18403-x Pubmed: 32948759 ]
- Peptidyl-prolyl cis-trans isomerase fkbp1b (11 kDa, Protein from Homo sapiens)
- Ryanodine receptor 1 bound to fkbp1b (2 MDa, Complex from Oryctolagus cuniculus)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Ryanodine receptor 1 (502 kDa, Protein from Oryctolagus cuniculus)