Structure of Src in complex with beta-arrestin 1 revealing SH3 binding sites
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9bt8
Q-score: 0.539
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Proto-oncogene tyrosine-protein kinase src (54 kDa, Protein from Gallus gallus)
- Antibody fragment fab30, light chain (23 kDa, Protein from Bacteriophage sp.)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Bacteriophage sp.)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Nanobody 32 (13 kDa, Protein from Lama glama)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment fab30 in complex with three-domain src (sh3-sh2-sh1). (Complex from Rattus norvegicus)
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
Structure of SH3 domain of Src in complex with beta-arrestin 1
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 9cx3
Q-score: 0.423
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Antibody fragment fab30, light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide, nanobody 32 and antibody fragment fab30 in complex with sh3 domain of src (Complex from Rattus norvegicus)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Mus musculus)
- Proto-oncogene tyrosine-protein kinase src (9 kDa, Protein from Gallus gallus)
- Nanobody 32 (13 kDa, Protein from Lama glama)
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
Structure of SH3 domain of Src in complex with beta-arrestin 1
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 9cx9
Q-score: 0.47
Pakharukova N, Thomas BN, Bansia H, Li L, Abzalimov RR, Kim J, Kahsai AW, Pani B, Bassford DK, Liu S, Zhang X, des Georges A, Lefkowitz RJ
bioRxiv (2024) [ Pubmed: 39131402 DOI: doi:10.1101/2024.07.31.605623 ]
- Antibody fragment fab30, light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin 1 bound to a g protein-coupled receptor phosphopeptide and antibody fragment fab30 in complex with sh3 domain of src (Complex from Rattus norvegicus)
- Antibody fragment fab30, heavy chain (25 kDa, Protein from Mus musculus)
- Beta-arrestin-1 (44 kDa, Protein from Rattus norvegicus)
- Proto-oncogene tyrosine-protein kinase src (9 kDa, Protein from Gallus gallus)
- Vasopressin v2 receptor (3 kDa, Protein from Homo sapiens)
Subtomogram averaged map of hACE2 dimers on the surface of extracellular vesicles
Marcink TC, Kicmal T, Armbruster E, Zhang Z, Zipursky G, Golub KL, Idris M, Khao J, Drew-Bear J, McGill G, Gallagher T, Porotto M, des Georges A, Moscona A
Sci Adv (2022) 8 pp. eabo3153-eabo3153 [ DOI: doi:10.1126/sciadv.abo3153 Pubmed: 35984891 ]
Cryo-EM Structure of Human Transferrin Receptor 1 bound to DNA Aptamer
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 7zqs
Q-score: 0.6
Cheng EL, Cardle II, Kacherovsky N, Bansia H, Wang T, Zhou Y, Raman J, Yen A, Gutierrez D, Salipante SJ, des Georges A, Jensen MC, Pun SH
J Am Chem Soc (2022) 144 pp. 13851-13864 [ Pubmed: 35875870 DOI: doi:10.1021/jacs.2c05349 ]
- Transferrin receptor protein 1 (84 kDa, Protein from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Human transferrin receptor 1 in complex with dna aptamer (190 kDa, Complex from Homo sapiens)
- Dna (30-mer) (15 kDa, DNA from unidentified)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Multidrug efflux pump subunit AcrB
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7rr6
Q-score: 0.52
Trinh TKH, Cabezas AJ, Joshi S, Catalano C, Siddique AB, Qiu W, Deshmukh S, des Georges A, Guo Y
Chem Sci (2023) 14 pp. 7310-7326 [ DOI: doi:10.1039/d3sc01890c Pubmed: 37416719 ]
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Dodecane (170 Da, Ligand)
- Multidrug efflux pump subunit acrb (Complex from Escherichia coli (strain K12))
- Phosphatidylethanolamine (734 Da, Ligand)
Multidrug efflux pump subunit AcrB
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 7rr7
Q-score: 0.517
Trinh TKH, Cabezas AJ, Joshi S, Catalano C, Siddique AB, Qiu W, Deshmukh S, des Georges A, Guo Y
Chem Sci (2023) 14 pp. 7310-7326 [ DOI: doi:10.1039/d3sc01890c Pubmed: 37416719 ]
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Dodecane (170 Da, Ligand)
- Multidrug efflux pump subunit acrb (Complex from Escherichia coli (strain K12))
- Phosphatidylethanolamine (734 Da, Ligand)
Multidrug efflux pump subunit AcrB
Resolution: 3.51 Å
EM Method: Single-particle
Fitted PDBs: 7rr8
Q-score: 0.547
Trinh TKH, Cabezas AJ, Joshi S, Catalano C, Siddique AB, Qiu W, Deshmukh S, des Georges A, Guo Y
Chem Sci (2023) 14 pp. 7310-7326 [ DOI: doi:10.1039/d3sc01890c Pubmed: 37416719 ]
- Multidrug efflux pump subunit acrb (114 kDa, Protein from Escherichia coli (strain K12))
- Dodecane (170 Da, Ligand)
- Multidrug efflux pump subunit acrb (Complex from Escherichia coli (strain K12))
- Phosphatidylethanolamine (734 Da, Ligand)
Small conductance mechanosensitive channel MscS
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7raz
Q-score: 0.418
Catalano C, Ben-Hail D, Qiu W, des Georges A, Guo Y
To Be Published
Low conductance mechanosensitive channel YnaI
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7n4t
Q-score: 0.557
Catalano C, Ben-Hail D, Qiu W, Blount P, des Georges A, Guo Y
Membranes (Basel) (2021) 11 [ DOI: doi:10.3390/membranes11110849 Pubmed: 34832078 ]