Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7upw
Q-score: 0.464
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- Three rbd-down state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (650 kDa, Complex)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7upx
Q-score: 0.513
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ Pubmed: 35951767 DOI: doi:10.1126/sciimmunol.add5446 ]
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Three rbd-down state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (local refinement of the rbd and fab variable domains) (6 MDa, Complex)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7upy
Q-score: 0.384
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ Pubmed: 35951767 DOI: doi:10.1126/sciimmunol.add5446 ]
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus)
- Sp1-77 fab heavy chain (49 kDa, Protein from Homo sapiens)
- Sp1-77 fab light chain (23 kDa, Protein from Homo sapiens)
- Sp1-77 fab heavy chain, sp1-77 fab light chain (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- One rbd-up state of sars-cov-2 d614g spike in complex with the sp1-77 neutralizing antibody fab fragment (650 kDa, Complex)
- Spike glycoprotein (144 kDa, Protein from Severe acute respiratory syndrome coronavirus)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ Pubmed: 35951767 DOI: doi:10.1126/sciimmunol.add5446 ]
- Sp1-77 antibody fab light chain (Protein from Mus musculus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Sp1-77 antibody fab heavy chain (Protein from Mus musculus)
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Complex of sars-cov2 2p spike with sp1-77 antibody fab (48 kDa, Complex)
- Sp1-77 antibody fab light chain, sp1-77 antibody fab heavy chain (Complex from Mus musculus)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ DOI: doi:10.1126/sciimmunol.add5446 Pubmed: 35951767 ]
- Vhh7-7-53 antibody fab light chain, vhh7-7-53 antibody fab heavy chain (Complex from Mus musculus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Vhh7-7-53 antibody heavy chain (Protein from Mus musculus)
- Vhh7-7-53 antibody light chain (Protein from Mus musculus)
- Complex of sars-cov2 2p spike with vhh7-7-53 antibody fab (48 kDa, Complex)
Luo S, Zhang J, Kreutzberger AJB, Eaton A, Edwards RJ, Jing C, Dai HQ, Sempowski GD, Cronin K, Parks R, Ye AY, Mansouri K, Barr M, Pishesha N, Williams AC, Vieira Francisco L, Saminathan A, Peng H, Batra H, Bellusci L, Khurana S, Alam SM, Montefiori DC, Saunders KO, Tian M, Ploegh H, Kirchhausen T, Chen B, Haynes BF, Alt FW
Sci Immunol (2022) 7 pp. eadd5446-eadd5446 [ Pubmed: 35951767 DOI: doi:10.1126/sciimmunol.add5446 ]
- Complex of sars-cov2 2p spike with vhh7-5-82 antibody fab (48 kDa, Complex)
- Vhh7-5-82 antibody fab light chain (Protein from Mus musculus)
- Sars-cov2 2p spike (Complex from Severe acute respiratory syndrome coronavirus)
- Sars-cov2 2p spike (Protein from Severe acute respiratory syndrome coronavirus)
- Vhh7-5-82 antibody fab heavy chain (Protein from Mus musculus)
- Vhh7-5-82 antibody fab light chain, vhh7-5-82 antibody fab heavy chain (Complex from Mus musculus)
IMM20184 and IMM20253 Fabs in ternary complex with SARS-CoV-2 receptor binding domain
Nikitin PA, DiMuzio JM, Dowling JP, Patel NB, Bingaman-Steele JL, Heimbach BC, Henriquez N, Nicolescu C, Polley A, Sikorski EL, Howanski RJ, Nath M, Shukla H, Scheaffer SM, Finn JP, Liang LF, Smith T, Storm N, McKay LGA, Johnson RI, Malsick LE, Honko AN, Griffiths A, Diamond MS, Sarma P, Geising DH, Morin MJ, Robinson MK
Sci Immunol (2022) 7 pp. eabl9943-eabl9943 [ Pubmed: 35771946 DOI: doi:10.1126/sciimmunol.abl9943 ]
- Imm20184 and imm20253 fabs in ternary complex with rbd of sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus)
- Imm20253 fab (Complex from Homo sapiens)
- Sars-cov-2 rbd (Complex from Severe acute respiratory syndrome coronavirus)
- Imm20184 fab (Complex from Homo sapiens)