Cryo-EM structure of the SARS-CoV-2 Spike bound to TMEM106B
Baggen J, Jacquemyn M, Persoons L, Vanstreels E, Pye VE, Wrobel AG, Calvaresi V, Martin SR, Roustan C, Cronin NB, Reading E, Thibaut HJ, Vercruysse T, Maes P, De Smet F, Yee A, Nivitchanyong T, Roell M, Franco-Hernandez N, Rhinn H, Mamchak AA, Ah Young-Chapon M, Brown E, Cherepanov P, Daelemans D
Cell (2023) 186 pp. 3427-3442.e22 [ DOI: doi:10.1016/j.cell.2023.06.005 Pubmed: 37421949 ]
- Sars-cov-2 spike ectodomain, hexa-pro stabilized; belgium/ghb-03021 variant (asp-484) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike ectodomain, hexa-pro stabilized; belgium/ghb-03021 variant (asp-484) (Protein from Severe acute respiratory syndrome coronavirus 2)
- Tmem106b lumenal domain (Protein from Homo sapiens)
- Tmem106b lumenal domain (Complex from Homo sapiens)
- Trimeric sars-cov-2 spike bound to one molecule of tmem106b (450 kDa, Complex)
Local refinement of the SARS-CoV-2 Spike RBD bound to TMEM106B
Baggen J, Jacquemyn M, Persoons L, Vanstreels E, Pye VE, Wrobel AG, Calvaresi V, Martin SR, Roustan C, Cronin NB, Reading E, Thibaut HJ, Vercruysse T, Maes P, De Smet F, Yee A, Nivitchanyong T, Roell M, Franco-Hernandez N, Rhinn H, Mamchak AA, Ah Young-Chapon M, Brown E, Cherepanov P, Daelemans D
Cell (2023) 186 pp. 3427-3442.e22 [ DOI: doi:10.1016/j.cell.2023.06.005 Pubmed: 37421949 ]
- Sars-cov-2 spike ectodomain (belgium/ghb-03021) stabilized in trimeric pre-fusion state (Complex from Severe acute respiratory syndrome coronavirus 2)
- Tmem106b lumenall domain (Protein from Homo sapiens)
- Tmem106b lumenall domain (Complex from Homo sapiens)
- Trimeric sars-cov-2 spike bound to one molecule of tmem106b (450 kDa, Complex)
- Sars-cov-2 spike ectodomain (belgium/ghb-03021) stabilized in trimeric pre-fusion state (Protein from Severe acute respiratory syndrome coronavirus 2)
S protein of SARS-CoV-2 in complex with 2G1
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7x08
Q-score: 0.458
Ma H, Guo Y, Tang H, Tseng CK, Wang L, Zong H, Wang Z, He Y, Chang Y, Wang S, Huang H, Ke Y, Yuan Y, Wu M, Zhang Y, Drelich A, Kempaiah KR, Peng BH, Wang A, Yang K, Yin H, Liu J, Yue Y, Xu W, Zhu S, Ji T, Zhang X, Wang Z, Li G, Liu G, Song J, Mu L, Xiang Z, Song Z, Chen H, Bian Y, Zhang B, Chen H, Zhang J, Liao Y, Zhang L, Yang L, Chen Y, Gilly J, Xiao X, Han L, Jiang H, Xie Y, Zhou Q, Zhu J
Cell Discov (2022) 8 pp. 16-16 [ DOI: doi:10.1038/s41421-022-00381-7 Pubmed: 35169121 ]
- S protein of sars-cov-2 in complex with 2g1 (Complex)
- Light chain of 2g1 (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Heavy chain of 2g1 (49 kDa, Protein from Homo sapiens)
- 2g1 (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus)
- Linoleic acid (280 Da, Ligand)
- S protein of sars-cov-2 (Complex from Severe acute respiratory syndrome coronavirus)
S protein of SARS-CoV-2 in complex with 2G1 focused on RBD_2G1 sub-complex
Ma H, Guo Y, Tang H, Tseng CK, Wang L, Zong H, Wang Z, He Y, Chang Y, Wang S, Huang H, Ke Y, Yuan Y, Wu M, Zhang Y, Drelich A, Kempaiah KR, Peng BH, Wang A, Yang K, Yin H, Liu J, Yue Y, Xu W, Zhu S, Ji T, Zhang X, Wang Z, Li G, Liu G, Song J, Mu L, Xiang Z, Song Z, Chen H, Bian Y, Zhang B, Chen H, Zhang J, Liao Y, Zhang L, Yang L, Chen Y, Gilly J, Xiao X, Han L, Jiang H, Xie Y, Zhou Q, Zhu J
Cell Discov (2022) 8 pp. 16-16 [ DOI: doi:10.1038/s41421-022-00381-7 Pubmed: 35169121 ]