Human E3 ligase E6AP in complex with HPV16-E6 and p53
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 9cht
Q-score: 0.263
Kenny S, Iyer S, Gabel CA, Tegenfeldt N, DeMarco AG, Hall MC, Chang L, Davisson VJ, Pol SV, Das C
Structure (2025) [ Pubmed: 39818213 DOI: doi:10.1016/j.str.2024.12.013 ]
- Ternary complex of e6ap with viral factor e6 and neosubstrate p53 (Complex from Homo sapiens)
- Immunoglobulin g-binding protein g/cellular tumor antigen p53 fusion protein (43 kDa, Protein from Homo sapiens)
- Ubiquitin-protein ligase e3a (102 kDa, Protein from Homo sapiens)
- Protein e6 (18 kDa, Protein from Human papillomavirus 16)
Structure of E6AP-E6 complex in Att1 state
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 8jrn
Q-score: 0.531
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ Pubmed: 38670961 DOI: doi:10.1038/s41467-024-47586-w ]
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of E6AP-E6 complex in Att2 state
Resolution: 3.01 Å
EM Method: Single-particle
Fitted PDBs: 8jro
Q-score: 0.492
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ Pubmed: 38670961 DOI: doi:10.1038/s41467-024-47586-w ]
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of E6AP-E6 complex in Att3 state
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 8jrp
Q-score: 0.34
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ Pubmed: 38670961 DOI: doi:10.1038/s41467-024-47586-w ]
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (17 kDa, Protein from Human papillomavirus 16)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of E6AP-E6 complex in Det1 state
Resolution: 4.15 Å
EM Method: Single-particle
Fitted PDBs: 8jrq
Q-score: 0.186
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ Pubmed: 38670961 DOI: doi:10.1038/s41467-024-47586-w ]
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (19 kDa, Protein from Human papillomavirus 16)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of E6AP-E6 complex in Det2 state
Resolution: 4.35 Å
EM Method: Single-particle
Fitted PDBs: 8jrr
Q-score: 0.164
Wang Z, Fan F, Li Z, Ye F, Wang Q, Gao R, Qiu J, Lv Y, Lin M, Xu W, Luo C, Yu X
Nat Commun (2024) 15 pp. 3531-3531 [ Pubmed: 38670961 DOI: doi:10.1038/s41467-024-47586-w ]
- E6ap-e6 complex (Complex from Homo sapiens)
- Protein e6 (16 kDa, Protein from Human papillomavirus 16)
- Zinc ion (65 Da, Ligand)
- Ubiquitin-protein ligase e3a (100 kDa, Protein from Homo sapiens)
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 8gcr
Q-score: 0.468
Wang JCK, Baddock HT, Mafi A, Foe IT, Bratkowski M, Lin TY, Jensvold ZD, Preciado Lopez M, Stokoe D, Eaton D, Hao Q, Nile AH
Nat Commun (2024) 15 pp. 1842-1842 [ DOI: doi:10.1038/s41467-024-45920-w Pubmed: 38418456 ]
- P53 (Complex from Homo sapiens)
- Ternary complex of hpv16 e6, e6ap, and p53 (Complex)
- Ubiquitin-protein ligase e3a (104 kDa, Protein from Homo sapiens)
- Hpv16 e6 - mbp fusion (Complex from Escherichia coli)
- Cellular tumor antigen p53 (24 kDa, Protein from Homo sapiens)
- E6ap (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Maltose/maltodextrin-binding periplasmic protein,protein e6 (61 kDa, Protein from Human papillomavirus type 16)
Monomeric E6AP-E6-p53 ternary complex
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8r1f
Q-score: 0.316
Sandate CR, Chakraborty D, Kater L, Kempf G, Thoma NH
bioRxiv (2023) [ DOI: doi:10.1101/2023.11.01.565136 ]
- Monomeric e6ap-e6-p53 ternary complex (176 kDa, Complex from Homo sapiens)
- Cellular tumor antigen p53 (46 kDa, Protein from Homo sapiens)
- Ubiquitin-like protein smt3,protein e6 (31 kDa, Protein from Human papillomavirus type 16)
- Ubiquitin-protein ligase e3a (103 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Dimeric ternary structure of E6AP-E6-p53
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 8r1g
Q-score: 0.175
Sandate CR, Chakraborty D, Kater L, Kempf G, Thoma NH
bioRxiv (2023) [ DOI: doi:10.1101/2023.11.01.565136 ]
- Dimeric e6ap-e6-p53 ternary complex (352 kDa, Complex from Homo sapiens)
- Cellular tumor antigen p53 (46 kDa, Protein from Homo sapiens)
- Ubiquitin-like protein smt3,protein e6 (31 kDa, Protein from Human papillomavirus type 16)
- Ubiquitin-protein ligase e3a (103 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7kzf
Q-score: 0.528
Goetschius DJ, Hartmann SR, Subramanian S, Bator CM, Christensen ND, Hafenstein SL
Sci Rep (2021) 11 pp. 3498-3498 [ DOI: doi:10.1038/s41598-021-83076-5 Pubmed: 33568731 ]