mGluR3 in the presence of the agonist LY379268 and PAM VU6023326
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8tqb
Q-score: 0.456
Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J
bioRxiv (2023) [ DOI: doi:10.1101/2023.08.13.552748 Pubmed: 37645747 ]
- Metabotropic glutamate receptor 3 dimer (260 kDa, Complex from Rattus norvegicus)
- (1r,4r,5s,6r)-4-azanyl-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (187 Da, Ligand)
- Metabotropic glutamate receptor 3 (103 kDa, Protein from Rattus norvegicus)
- Calcium ion (40 Da, Ligand)
Metabotropic glutamate receptor 3 class 3 bound to antagonist LY 341495
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8tr0
Q-score: 0.436
Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J
bioRxiv (2023) [ DOI: doi:10.1101/2023.08.13.552748 Pubmed: 37645747 ]
- Metabotropic glutamate receptor 3 dimer (260 kDa, Complex from Rattus norvegicus)
- Metabotropic glutamate receptor 3 (103 kDa, Protein from Rattus norvegicus)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
mGluR3 in the presence of the agonist LY379268
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8tr2
Q-score: 0.473
Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J
bioRxiv (2023) [ DOI: doi:10.1101/2023.08.13.552748 Pubmed: 37645747 ]
- Metabotropic glutamate receptor 3 dimer (260 kDa, Complex from Rattus norvegicus)
- (1s,4r,5r,6s)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (187 Da, Ligand)
- Metabotropic glutamate receptor 3 (103 kDa, Protein from Rattus norvegicus)
- Calcium ion (40 Da, Ligand)
mGluR3 in the presence of the antagonist LY 341495 and positive allosteric modulator VU6023326
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8trc
Q-score: 0.393
Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J
bioRxiv (2023) [ DOI: doi:10.1101/2023.08.13.552748 Pubmed: 37645747 ]
- Metabotropic glutamate receptor 3 dimer (260 kDa, Complex from Rattus norvegicus)
- Metabotropic glutamate receptor 3 (103 kDa, Protein from Rattus norvegicus)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
mGluR3 class 1 in the presence of the antagonist LY 341495
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8trd
Q-score: 0.41
Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Arefin A, Huynh K, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J
Nat Commun (2024) 15 pp. 6498-6498 [ DOI: doi:10.1038/s41467-024-50548-x Pubmed: 39090128 ]
- Metabotropic glutamate receptor 3 dimer (260 kDa, Complex from Rattus norvegicus)
- Metabotropic glutamate receptor 3 (103 kDa, Protein from Rattus norvegicus)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
metabotropic glutamate receptor subtype three bound to the antagonist LY 341495, class two
Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J
bioRxiv (2023) [ DOI: doi:10.1101/2023.08.13.552748 Pubmed: 37645747 ]
Strauss A, Gonzalez-Hernandez AJ, Lee J, Abreu N, Selvakumar P, Salas-Estrada L, Kristt M, Arefin A, Huynh K, Marx DC, Gilliland K, Melancon BJ, Filizola M, Meyerson J, Levitz J
Nat Commun (2024) 15 pp. 6498-6498 [ DOI: doi:10.1038/s41467-024-50548-x Pubmed: 39090128 ]
- Metabotropic glutamate receptor 3 dimer (260 kDa, Complex from Rattus norvegicus)