Electron Microscopy Data Bank

EMPIAR-11358

Release date: Jan. 20, 2023
Dataset size: 1.5 TB
Experiment type: EMDB

He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim C

Nature (2022) 608 pp. 826-832 [ DOI: 10.1038/s41586-022-05040-1 Pubmed: 35830881 ]

Image sets:

Unaligned frames for CST-Pola-primase + 3xTEL DNA

EMPIAR-11359

Release date: Jan. 20, 2023
Dataset size: 1.9 TB
Experiment type: EMDB

He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim C

Nature (2022) 608 pp. 826-832 [ DOI: 10.1038/s41586-022-05040-1 Pubmed: 35830881 ]

Image sets:

Unaligned frames for CST-Pola-primase + 6xTEL DNA

EMPIAR-11360

Release date: Jan. 20, 2023
Dataset size: 1.6 TB
Experiment type: EMDB

He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim C

Nature (2022) 608 pp. 826-832 [ DOI: 10.1038/s41586-022-05040-1 Pubmed: 35830881 ]

Image sets:

Unaligned frames for CST-Pola-primase + 4xTEL foldback DNA

EMD-27097

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Human CST-DNA polymerase alpha/primase preinitiation complex bound to 3xTEL template

Release date: June 22, 2022
Resolution: 3.62 Å
EM Method: Single-particle

He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ

Nature (2022) 608 pp. 826-832 [ Pubmed: 35830881 DOI: doi:10.1038/s41586-022-05040-1 ]

Sample:

Prim2 (Protein from Homo sapiens)
Pola1 (Protein from Homo sapiens)
C-3xtel (DNA from Homo sapiens)
Ten1 (Protein from Homo sapiens)
Stn1 (Protein from Homo sapiens)
Human cst-dna polymerase alpha/primase preinitiation complex bound to 3xtel template (540 kDa, Complex from Homo sapiens)
Prim1 (Protein from Homo sapiens)
Ctc1 (Protein from Homo sapiens)
Pola2 (Protein from Homo sapiens)

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EMD-27099

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Human CST-DNA polymerase alpha/primase preinitiation complex bound to 3xTEL template - local refined domains and merged

Release date: June 22, 2022
Resolution: 3.61 Å
EM Method: Single-particle

He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ

Nature (2022) 608 pp. 826-832 [ Pubmed: 35830881 DOI: doi:10.1038/s41586-022-05040-1 ]

Sample:

Prim2 (Protein from Homo sapiens)
Pola1 (Protein from Homo sapiens)
C-3xtel (DNA from Homo sapiens)
Ten1 (Protein from Homo sapiens)
Stn1 (Protein from Homo sapiens)
Human cst-dna polymerase alpha/primase preinitiation complex bound to 3xtel template - local refined domains and merged (540 kDa, Complex from Homo sapiens)
Prim1 (Protein from Homo sapiens)
Ctc1 (Protein from Homo sapiens)
Pola2 (Protein from Homo sapiens)

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EMD-27104

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Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template

Release date: June 22, 2022
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8d0b
Q-score: 0.417

He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ

Nature (2022) 608 pp. 826-832 [ Pubmed: 35830881 DOI: doi:10.1038/s41586-022-05040-1 ]

Sample:

Cst complex subunit stn1 (41 kDa, Protein from Homo sapiens)
Cst complex subunit ten1 (13 kDa, Protein from Homo sapiens)
Cst complex subunit ctc1 (133 kDa, Protein from Homo sapiens)
Dna polymerase alpha subunit b (50 kDa, Protein from Homo sapiens)
Dna (5'-d(p*tp*ap*gp*gp*gp*tp*tp*ap*gp*gp*gp*tp*tp*ap*g)-3') (4 kDa, DNA from Homo sapiens)
Dna primase large subunit (28 kDa, Protein from Homo sapiens)
Dna primase small subunit (49 kDa, Protein from Homo sapiens)
Dna polymerase alpha catalytic subunit (130 kDa, Protein from Homo sapiens)
Human cst-dna polymerase alpha/primase preinitiation complex bound to 4xtel-foldback dna template (540 kDa, Complex from Homo sapiens)

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EMD-27107

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Human CST-DNA polymerase alpha/primase preinitiation complex bound to 4xTEL-foldback template - PRIM2C advanced PIC

Release date: June 22, 2022
Resolution: 4.27 Å
EM Method: Single-particle
Fitted PDBs: 8d0k
Q-score: 0.311

He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ

Nature (2022) 608 pp. 826-832 [ Pubmed: 35830881 DOI: doi:10.1038/s41586-022-05040-1 ]

Sample:

Dna (5'-d(p*tp*ap*gp*gp*gp*tp*tp*ap*gp*gp*gp*tp*tp*ap*gp*gp*gp*tp*tp*a)-3') (18 kDa, DNA from Homo sapiens)
Dna polymerase alpha subunit b (67 kDa, Protein from Homo sapiens)
Cst complex subunit ctc1 (138 kDa, Protein from Homo sapiens)
Cst complex subunit stn1 (43 kDa, Protein from Homo sapiens)
Cst complex subunit ten1 (17 kDa, Protein from Homo sapiens)
Dna polymerase alpha catalytic subunit (172 kDa, Protein from Homo sapiens)
Dna primase large subunit (60 kDa, Protein from Homo sapiens)
Dna primase small subunit (51 kDa, Protein from Homo sapiens)
Human cst-dna polymerase alpha/primase advanced preinitiation complex bound to 4xtel-foldback dna template (540 kDa, Complex from Homo sapiens)

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EMD-27109

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Human CST-DNA polymerase alpha/primase preinitiation complex bound to 6xTEL DNA template

Release date: June 22, 2022
Resolution: 3.69 Å
EM Method: Single-particle

He Q, Lin X, Chavez BL, Agrawal S, Lusk BL, Lim CJ

Nature (2022) 608 pp. 826-832 [ Pubmed: 35830881 DOI: doi:10.1038/s41586-022-05040-1 ]

Sample:

Prim2 (Protein from Homo sapiens)
Pola1 (Protein from Homo sapiens)
Ten1 (Protein from Homo sapiens)
Stn1 (Protein from Homo sapiens)
Prim1 (Protein from Homo sapiens)
Ctc1 (Protein from Homo sapiens)
C-6xtel (Protein from Homo sapiens)
Human cst-dna polymerase alpha/primase preinitiation complex bound to 6xtel dna template (540 kDa, Complex from Homo sapiens)
Pola2 (Protein from Homo sapiens)

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