Cryo-EM structure of long form insulin receptor (IR-B) in the apo state
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8u4b
Q-score: 0.388
An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E
Nat Commun (2024) 15 pp. 2609-2609 [ DOI: doi:10.1038/s41467-024-46990-6 Pubmed: 38521788 ]
- Long form insulin receptor in the apo state (Complex from Homo sapiens)
- Insulin receptor (156 kDa, Protein from Homo sapiens)
Cryo-EM structure of long form insulin receptor (IR-B) with four IGF2 bound, symmetric conformation.
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8u4c
Q-score: 0.359
An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E
Nat Commun (2024) 15 pp. 2609-2609 [ DOI: doi:10.1038/s41467-024-46990-6 Pubmed: 38521788 ]
- Long form insulin receptor (ir-b) with four igf2 bound, symmetric conformation. (Complex from Homo sapiens)
- Insulin receptor (156 kDa, Protein from Homo sapiens)
- Insulin-like growth factor ii (20 kDa, Protein from Homo sapiens)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 8u4e
Q-score: 0.279
An W, Hall C, Li J, Hung A, Wu J, Park J, Wang L, Bai XC, Choi E
Nat Commun (2024) 15 pp. 2609-2609 [ DOI: doi:10.1038/s41467-024-46990-6 Pubmed: 38521788 ]
- Insulin receptor (156 kDa, Protein from Homo sapiens)
- Long form insulin receptor (ir-b) with three igf2 bound, asymmetric conformation. (Complex from Homo sapiens)
- Insulin-like growth factor ii (20 kDa, Protein from Homo sapiens)
DNQX-bound GluK2-1xNeto2 complex, with asymmetric LBD
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7f56
Q-score: 0.309
He L, Sun J, Gao Y, Li B, Wang Y, Dong Y, An W, Li H, Yang B, Ge Y, Zhang XC, Shi YS, Zhao Y
Nature (2021) 599 pp. 325-329 [ Pubmed: 34552241 DOI: doi:10.1038/s41586-021-03936-y ]
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
- Dnqx-bound gluk2-1xneto2 complex, with asymmetric lbd (Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neuropilin and tolloid-like protein 2 (59 kDa, Protein from Rattus norvegicus)
Kainate-bound GluK2-1xNeto2 complex, at the desensitized state
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7f57
Q-score: 0.373
He L, Sun J, Gao Y, Li B, Wang Y, Dong Y, An W, Li H, Yang B, Ge Y, Zhang XC, Shi YS, Zhao Y
Nature (2021) 599 pp. 325-329 [ Pubmed: 34552241 DOI: doi:10.1038/s41586-021-03936-y ]
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Kainate-bound gluk2-1xneto2 complex, at the desensitized state (Complex from Rattus norvegicus)
- Neuropilin and tolloid-like protein 2 (59 kDa, Protein from Rattus norvegicus)
DNQX-bound GluK2-1xNeto2 complex
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 7f59
Q-score: 0.311
He L, Sun J, Gao Y, Li B, Wang Y, Dong Y, An W, Li H, Yang B, Ge Y, Zhang XC, Shi YS, Zhao Y
Nature (2021) 599 pp. 325-329 [ Pubmed: 34552241 DOI: doi:10.1038/s41586-021-03936-y ]
- Neuropilin and tolloid-like protein 2 (59 kDa, Protein from Rattus norvegicus)
- Dnqx-bound gluk2-1xneto2 complex (Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)
DNQX-bound GluK2-2xNeto2 complex
Resolution: 6.4 Å
EM Method: Single-particle
Fitted PDBs: 7f5a
Q-score: 0.171
He L, Sun J, Gao Y, Li B, Wang Y, Dong Y, An W, Li H, Yang B, Ge Y, Zhang XC, Shi YS, Zhao Y
Nature (2021) 599 pp. 325-329 [ Pubmed: 34552241 DOI: doi:10.1038/s41586-021-03936-y ]
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
- Structure of a complex (Complex from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neuropilin and tolloid-like protein 2 (59 kDa, Protein from Rattus norvegicus)
LBD-TMD focused reconstruction of DNQX-bound GluK2-1xNeto2 complex
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7f5b
Q-score: 0.405
He L, Sun J, Gao Y, Li B, Wang Y, Dong Y, An W, Li H, Yang B, Ge Y, Zhang XC, Shi YS, Zhao Y
Nature (2021) 599 pp. 325-329 [ Pubmed: 34552241 DOI: doi:10.1038/s41586-021-03936-y ]
- Neuropilin and tolloid-like protein 2 (59 kDa, Protein from Rattus norvegicus)
- Calcium ion (40 Da, Ligand)
- Lbd-tmd focused reconstruction of dnqx-bound gluk2-1xneto2 complex (Complex from Rattus norvegicus)
- Glutamate receptor ionotropic, kainate 2 (102 kDa, Protein from Rattus norvegicus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (1s)-2-{[{[(2r)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(palmitoyloxy)methyl]ethyl stearate (751 Da, Ligand)