Local refinement of SARS-CoV-2 (HP-GSAS-Mut7) spike NTD in complex with TXG-0078 Fab
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 8swh
Q-score: 0.326
Hurtado J, Rogers TF, Jaffe DB, Adams BA, Bangaru S, Garcia E, Capozzola T, Messmer T, Sharma P, Song G, Beutler N, He W, Dueker K, Musharrafieh R, Burbach S, Truong A, Stubbington MJT, Burton DR, Andrabi R, Ward AB, McDonnell WJ, Briney B
Cell Rep (2024) 43 pp. 114307-114307 [ Pubmed: 38848216 DOI: doi:10.1016/j.celrep.2024.114307 ]
- Txg-0078 fab heavy chain (16 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Structure of sars-cov-2(hp-gsas-mut7) spike in complex with txg-0078 fab- local refinement (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Txg-0078 fab light chain (14 kDa, Protein from Homo sapiens)
CC6.33 IgG in complex with SARS-CoV-2-6P-Mut7 S protein (non-uniform refinement)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ru3
Q-score: 0.413
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ Pubmed: 35971553 DOI: doi:10.1016/j.isci.2022.104914 ]
- Cc6.33 igg kappa chain fv (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg in complex with sars-2-cov-6p-mut7 s protein (Complex)
- Cc6.33 igg heavy chain fv (12 kDa, Protein from Homo sapiens)
CC6.33 IgG in complex with SARS-CoV-2-6P-Mut7 S protein (RBD/Fv local refinement)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ru4
Q-score: 0.457
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ Pubmed: 35971553 DOI: doi:10.1016/j.isci.2022.104914 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cc6.33 igg heavy chain fv (12 kDa, Protein from Homo sapiens)
- Cc6.33 igg in complex with sars-2-cov-6p-mut7 s protein (Complex)
- Cc6.33 igg kappa chain fv (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg (Complex from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7ru5
Q-score: 0.315
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab kappa chain fv (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab heavy chain fv (13 kDa, Protein from Homo sapiens)
- Cc6.30 fab in complex with sars-cov-2-6p-mut7 s protein (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cc6.30 fab (Complex from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7ru8
Q-score: 0.334
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
- Cc6.30 fab in complex with sars-2-cov-6p-mut7 s protein (Complex)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab kappa chain fv (11 kDa, Protein from Homo sapiens)
- Cc6.30 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab heavy chain fv (13 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cc6.30 fab (Complex from Homo sapiens)
SARS-2 CoV 6P Mut7 in complex with Fab CC84.5
He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schafer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R
Nat Immunol (2022) 23 pp. 960-970 [ Pubmed: 35654851 DOI: doi:10.1038/s41590-022-01222-1 ]
SARS-2 CoV 6P Mut7 in complex with Fab CC25.1
He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schafer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R
Nat Immunol (2022) 23 pp. 960-970 [ Pubmed: 35654851 DOI: doi:10.1038/s41590-022-01222-1 ]
SARS-2 CoV 6P Mut7 in complex with Fab CC25.54
He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schafer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R
Nat Immunol (2022) 23 pp. 960-970 [ DOI: doi:10.1038/s41590-022-01222-1 Pubmed: 35654851 ]
SARS-2 CoV 6P Mut7 + Fab CC25.52
He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schafer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R
Nat Immunol (2022) 23 pp. 960-970 [ Pubmed: 35654851 DOI: doi:10.1038/s41590-022-01222-1 ]
SARS-2 CoV 6P Mut7 in complex with Fab CC25.56
He WT, Musharrafieh R, Song G, Dueker K, Tse LV, Martinez DR, Schafer A, Callaghan S, Yong P, Beutler N, Torres JL, Volk RM, Zhou P, Yuan M, Liu H, Anzanello F, Capozzola T, Parren M, Garcia E, Rawlings SA, Smith DM, Wilson IA, Safonova Y, Ward AB, Rogers TF, Baric RS, Gralinski LE, Burton DR, Andrabi R
Nat Immunol (2022) 23 pp. 960-970 [ Pubmed: 35654851 DOI: doi:10.1038/s41590-022-01222-1 ]