Cryo-EM reconstruction of SARS-CoV-2 M protein dimer in LMNG/CHS micelle
SARS-CoV-2 M protein dimer (long form) in complex with YN7756_1 Fab
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7vgr
Q-score: 0.504
Zhang Z, Nomura N, Muramoto Y, Ekimoto T, Uemura T, Liu K, Yui M, Kono N, Aoki J, Ikeguchi M, Noda T, Iwata S, Ohto U, Shimizu T
Nat Commun (2022) 13 pp. 4399-4399 [ Pubmed: 35931673 DOI: doi:10.1038/s41467-022-32019-3 ]
- Membrane protein (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Yn7756_1 fab (Complex from Mus musculus)
- Sars-cov-2 m protein dimer (long form) in complex with yn7756_1 fab (Complex)
- Yn7756_1 fab heavy chain (25 kDa, Protein from Mus musculus)
- Yn7756_1 fab light chain (24 kDa, Protein from Mus musculus)
- Membrane protein (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 M protein dimer (short form) in complex with YN7717_9 Fab
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7vgs
Q-score: 0.451
Zhang Z, Nomura N, Muramoto Y, Ekimoto T, Uemura T, Liu K, Yui M, Kono N, Aoki J, Ikeguchi M, Noda T, Iwata S, Ohto U, Shimizu T
Nat Commun (2022) 13 pp. 4399-4399 [ Pubmed: 35931673 DOI: doi:10.1038/s41467-022-32019-3 ]
- Membrane protein (28 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Yn7717_9 fab heavy chain (24 kDa, Protein from Mus musculus)
- Yn7717_9 fab (Complex from Mus musculus)
- Sars-cov-2 m protein dimer (short form) in complex with yn7717_9 fab (Complex)
- Membrane protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Yn7717_9 fab light chain (23 kDa, Protein from Mus musculus)
human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6os9
Q-score: 0.51
Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G
Nature (2019) 572 pp. 80-85 [ Pubmed: 31243364 DOI: doi:10.1038/s41586-019-1337-6 ]
- Neurotensin receptor type 1 (48 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hntsr1-gi1 complex in canonical conformation (c state) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Jmv449 (762 Da, Protein from synthetic construct)
- Scfv16 (27 kDa, Protein from Mus musculus)
human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 6osa
Q-score: 0.497
Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G
Nature (2019) 572 pp. 80-85 [ Pubmed: 31243364 DOI: doi:10.1038/s41586-019-1337-6 ]
- Neurotensin receptor type 1 (48 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Hntsr1-gi1 complex in non-canonical conformation (nc state) (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Jmv449 (762 Da, Protein from synthetic construct)