Resolution: 3.25 Å
EM Method: Single-particle
Fitted PDBs: 8rmr
Q-score: 0.326
Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, Cusack S
Nat Commun (2024) 15 pp. 6910-6910 [ Pubmed: 39160148 DOI: doi:10.1038/s41467-024-51007-3 ]
- Asymmetric dimer composed of one flupola/h7n9-4m replicase and one flupola/h7n9-4m encapsidase, bridged by human anp32a (Complex from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Polymerase basic protein 2 (89 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Magnesium ion (24 Da, Ligand)
- Acidic leucine-rich nuclear phosphoprotein 32 family member a (31 kDa, Protein from Homo sapiens)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, Cusack S
Nat Commun (2024) 15 pp. 6910-6910 [ Pubmed: 39160148 DOI: doi:10.1038/s41467-024-51007-3 ]
- Heterotrimeric complex (Complex from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Magnesium ion (24 Da, Ligand)
- Polymerase basic protein 2 (89 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, Cusack S
Nat Commun (2024) 15 pp. 6910-6910 [ Pubmed: 39160148 DOI: doi:10.1038/s41467-024-51007-3 ]
- Polymerase acidic protein (82 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Heterotrimeric complex (from the asymmetric dimer composed of one flupola/h7n9-4m replicase and one flupola/h7n9-4m encapsidase, bridged by human anp32a) (Complex from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Polymerase basic protein 2 (89 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Acidic leucine-rich nuclear phosphoprotein 32 family member a (31 kDa, Protein from Homo sapiens)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
Influenza B polymerase, monomeric encapsidase with 5' cRNA hook bound
Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, Cusack S
Nat Commun (2024) 15 pp. 6910-6910 [ Pubmed: 39160148 DOI: doi:10.1038/s41467-024-51007-3 ]
- Rna-directed rna polymerase catalytic subunit (84 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Polymerase basic protein 2 (90 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Polymerase acidic protein (83 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- 5' crna hook (1-12) (3 kDa, RNA from Influenza B virus (B/Memphis/13/2003))
- Heterotrimeric complex (Complex from Influenza B virus (B/Memphis/13/2003))
Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, Cusack S
Nat Commun (2024) 15 pp. 6910-6910 [ Pubmed: 39160148 DOI: doi:10.1038/s41467-024-51007-3 ]
- Rna-directed rna polymerase catalytic subunit (84 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Heterotrimeric complex from a pseudo-symmetrical dimer (Complex from Influenza B virus (B/Memphis/13/2003))
- Polymerase basic protein 2 (90 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Polymerase acidic protein (83 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Magnesium ion (24 Da, Ligand)
Influenza B polymerase, replicase (from "Influenza B polymerase apo-trimer" | Local refinement)
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8rn9
Q-score: 0.433
Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, Cusack S
Nat Commun (2024) 15 pp. 6910-6910 [ Pubmed: 39160148 DOI: doi:10.1038/s41467-024-51007-3 ]
- Heterotrimeric complex (Complex from Influenza B virus (B/Memphis/13/2003))
- Rna-directed rna polymerase catalytic subunit (84 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Polymerase acidic protein (83 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Polymerase basic protein 2 (90 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
Influenza B polymerase apo-trimer
Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, Cusack S
Nat Commun (2024) 15 pp. 6910-6910 [ Pubmed: 39160148 DOI: doi:10.1038/s41467-024-51007-3 ]
- Rna-directed rna polymerase catalytic subunit (84 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Influenza b polymerase apo-trimer (Complex from Influenza B virus (B/Memphis/13/2003))
- Polymerase basic protein 2 (90 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Polymerase acidic protein (83 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Acidic leucine-rich nuclear phosphoprotein 32 family member a (31 kDa, Protein from Homo sapiens)
Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, Cusack S
Nat Commun (2024) 15 pp. 6910-6910 [ Pubmed: 39160148 DOI: doi:10.1038/s41467-024-51007-3 ]
- Rna-directed rna polymerase catalytic subunit (84 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Polymerase basic protein 2 (90 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Polymerase acidic protein (83 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Acidic leucine-rich nuclear phosphoprotein 32 family member a (31 kDa, Protein from Homo sapiens)
- Heterotrimeric complex (Complex from Influenza B virus (B/Memphis/13/2003))
Arragain B, Krischuns T, Pelosse M, Drncova P, Blackledge M, Naffakh N, Cusack S
Nat Commun (2024) 15 pp. 6910-6910 [ Pubmed: 39160148 DOI: doi:10.1038/s41467-024-51007-3 ]
- Rna-directed rna polymerase catalytic subunit (84 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Asymmetric dimer of two flupolb heterotrimers, bridged by human anp32a (Complex from Influenza B virus (B/Memphis/13/2003))
- Polymerase basic protein 2 (90 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Polymerase acidic protein (83 kDa, Protein from Influenza B virus (B/Memphis/13/2003))
- Acidic leucine-rich nuclear phosphoprotein 32 family member a (31 kDa, Protein from Homo sapiens)
Influenza A/H7N9 polymerase symmetric dimer bound to the promoter (PA K289A/C489R)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8poh
Q-score: 0.497
Krischuns T, Arragain B, Isel C, Paisant S, Budt M, Wolff T, Cusack S, Naffakh N
Nat Commun (2024) 15 pp. 1064-1064 [ DOI: doi:10.1038/s41467-024-45205-2 Pubmed: 38316757 ]
- 51-mer vrna loop (v51_mut_s) (16 kDa, RNA from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Polymerase acidic protein, rna-directed rna polymerase catalytic subunit and polymerase basic protein 2 (Complex from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- 51-mer vrna loop (v51_mut_s) (Complex from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Influenza a/h7n9 polymerase in replicase-like conformation in pre-initiation state with pol ii ps5 ctd peptide mimic bound in site 1a/2a (Complex)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Magnesium ion (24 Da, Ligand)
- Polymerase acidic protein (84 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Polymerase basic protein 2 (88 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))