Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8pm0
Q-score: 0.546
Krischuns T, Arragain B, Isel C, Paisant S, Budt M, Wolff T, Cusack S, Naffakh N
Nat Commun (2024) 15 pp. 1064-1064 [ DOI: doi:10.1038/s41467-024-45205-2 Pubmed: 38316757 ]
- 51-mer vrna loop (v51_mut_s) (16 kDa, RNA from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Polymerase acidic protein (84 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Rna pol ii ctd 6 repeats (site 1a/2a) (4 kDa, Protein from Homo sapiens)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Polymerase basic protein 2 (89 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Magnesium ion (24 Da, Ligand)
- Influenza a/h7n9 polymerase in replicase-like conformation in pre-initiation state with pol ii ps5 ctd peptide mimic bound in site 1a/2a (Complex from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
Resolution: 2.49 Å
EM Method: Single-particle
Fitted PDBs: 8pnp
Q-score: 0.611
Krischuns T, Arragain B, Isel C, Paisant S, Budt M, Wolff T, Cusack S, Naffakh N
Nat Commun (2024) 15 pp. 1064-1064 [ DOI: doi:10.1038/s41467-024-45205-2 Pubmed: 38316757 ]
- 51-mer vrna loop (v51_mut_s) (16 kDa, RNA from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Rna pol ii ctd 6 repeats (site 1a/2a) (4 kDa, Protein from Homo sapiens)
- Polymerase acidic protein (84 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Polymerase basic protein 2 (89 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Influenza a/h7n9 polymerase in replicase-like conformation in pre-initiation state with pol ii ps5 ctd peptide mimic bound in site 1a/2a (Complex from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Water (18 Da, Ligand)
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8pnq
Q-score: 0.586
Krischuns T, Arragain B, Isel C, Paisant S, Budt M, Wolff T, Cusack S, Naffakh N
Nat Commun (2024) 15 pp. 1064-1064 [ DOI: doi:10.1038/s41467-024-45205-2 Pubmed: 38316757 ]
- 51-mer vrna loop (v51_mut_s) (16 kDa, RNA from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Rna pol ii ctd 6 repeats (site 1a/2a) (4 kDa, Protein from Homo sapiens)
- Polymerase acidic protein (84 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Polymerase basic protein 2 (89 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Magnesium ion (24 Da, Ligand)
- Rna-directed rna polymerase catalytic subunit (86 kDa, Protein from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- Influenza a/h7n9 polymerase in replicase-like conformation in pre-initiation state with pol ii ps5 ctd peptide mimic bound in site 1a/2a (Complex from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
- 5'-o-[(s)-hydroxy{[(s)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]uridine (483 Da, Ligand)
- Replication product (10 kDa, RNA from Influenza A virus (A/Zhejiang/DTID-ZJU01/2013(H7N9)))
Resolution: 2.42 Å
EM Method: Single-particle
Fitted PDBs: 8psz
Q-score: 0.647
Arragain B, Pelosse M, Thompson A, Cusack S
Nat Commun (2023) 14 pp. 8145-8145 [ Pubmed: 38066000 DOI: doi:10.1038/s41467-023-44044-x ]
- Zinc ion (65 Da, Ligand)
- 5' vrna end - vrna loop (40-mer) (12 kDa, RNA from Tilapia lake virus)
- Tilapia lake virus polymerase (Complex from Tilapia lake virus)
- Putative pb1 (57 kDa, Protein from Tilapia lake virus)
- Rna-dependent rna polymerase (53 kDa, Protein from Tilapia lake virus)
- Transcription-like product (6 kDa, RNA from Tilapia lake virus)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- [(2~{r},3~{s},4~{r},5~{r})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{n}-[oxidanyl(phosphonooxy)phosphoryl]phosphonamidic acid (482 Da, Ligand)
- Polymerase acidic protein (pa-like) (47 kDa, Protein from Tilapia lake virus)
Tilapia Lake Virus polymerase in vRNA initiation state (transcriptase conformation)
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8psn
Q-score: 0.632
Arragain B, Pelosse M, Thompson A, Cusack S
Nat Commun (2023) 14 pp. 8145-8145 [ Pubmed: 38066000 DOI: doi:10.1038/s41467-023-44044-x ]
- Zinc ion (65 Da, Ligand)
- 5' vrna end - vrna loop (40-mer) (12 kDa, RNA from Tilapia lake virus)
- Tilapia lake virus polymerase (Complex from Tilapia lake virus)
- Dna (5'-d(*(ctp))-3') (483 Da, DNA from synthetic construct)
- Putative pb1 (57 kDa, Protein from Tilapia lake virus)
- Rna-dependent rna polymerase (53 kDa, Protein from Tilapia lake virus)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Polymerase acidic protein (pa-like) (47 kDa, Protein from Tilapia lake virus)
Tilapia Lake Virus polymerase in vRNA initiation state (core only)
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 8pso
Q-score: 0.679
Arragain B, Pelosse M, Thompson A, Cusack S
Nat Commun (2023) 14 pp. 8145-8145 [ Pubmed: 38066000 DOI: doi:10.1038/s41467-023-44044-x ]
- Zinc ion (65 Da, Ligand)
- 5' vrna end - vrna loop (40-mer) (12 kDa, RNA from Tilapia lake virus)
- Tilapia lake virus polymerase (Complex from Tilapia lake virus)
- Dna (5'-d(*(ctp))-3') (483 Da, DNA from synthetic construct)
- Putative pb1 (57 kDa, Protein from Tilapia lake virus)
- Rna-dependent rna polymerase (53 kDa, Protein from Tilapia lake virus)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Polymerase acidic protein (pa-like) (47 kDa, Protein from Tilapia lake virus)
Tilapia Lake Virus polymerase in cRNA pre-initiation state mode A (core only)
Resolution: 2.65 Å
EM Method: Single-particle
Fitted PDBs: 8psq
Q-score: 0.648
Arragain B, Pelosse M, Thompson A, Cusack S
Nat Commun (2023) 14 pp. 8145-8145 [ Pubmed: 38066000 DOI: doi:10.1038/s41467-023-44044-x ]
- Zinc ion (65 Da, Ligand)
- 5' crna end - crna loop (40-mer) (12 kDa, RNA from Tilapia lake virus)
- Tilapia lake virus polymerase (Complex from Tilapia lake virus)
- Putative pb1 (57 kDa, Protein from Tilapia lake virus)
- Rna-dependent rna polymerase (53 kDa, Protein from Tilapia lake virus)
- Magnesium ion (24 Da, Ligand)
- Water (18 Da, Ligand)
- Polymerase acidic protein (pa-like) (47 kDa, Protein from Tilapia lake virus)
Tilapia Lake Virus polymerase in cRNA pre-initiation state mode B (core-endo only)
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 8pss
Q-score: 0.586
Arragain B, Pelosse M, Thompson A, Cusack S
Nat Commun (2023) 14 pp. 8145-8145 [ Pubmed: 38066000 DOI: doi:10.1038/s41467-023-44044-x ]
- Zinc ion (65 Da, Ligand)
- 5' crna end - crna loop (40-mer) (12 kDa, RNA from Tilapia lake virus)
- Tilapia lake virus polymerase (Complex from Tilapia lake virus)
- Putative pb1 (57 kDa, Protein from Tilapia lake virus)
- Rna-dependent rna polymerase (53 kDa, Protein from Tilapia lake virus)
- Magnesium ion (24 Da, Ligand)
- Polymerase acidic protein (pa-like) (47 kDa, Protein from Tilapia lake virus)
Tilapia Lake Virus polymerase in vRNA pre-initiation state mode A (core only)
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8psu
Q-score: 0.572
Arragain B, Pelosse M, Thompson A, Cusack S
Nat Commun (2023) 14 pp. 8145-8145 [ Pubmed: 38066000 DOI: doi:10.1038/s41467-023-44044-x ]
- Zinc ion (65 Da, Ligand)
- 5' vrna end - vrna loop (40-mer) (12 kDa, RNA from Tilapia lake virus)
- Tilapia lake virus polymerase (Complex from Tilapia lake virus)
- Putative pb1 (57 kDa, Protein from Tilapia lake virus)
- Rna-dependent rna polymerase (53 kDa, Protein from Tilapia lake virus)
- Polymerase acidic protein (pa-like) (47 kDa, Protein from Tilapia lake virus)
Tilapia Lake Virus polymerase in vRNA elongation state (transcriptase conformation)
Resolution: 2.96 Å
EM Method: Single-particle
Fitted PDBs: 8psx
Q-score: 0.595
Arragain B, Pelosse M, Thompson A, Cusack S
Nat Commun (2023) 14 pp. 8145-8145 [ Pubmed: 38066000 DOI: doi:10.1038/s41467-023-44044-x ]
- Zinc ion (65 Da, Ligand)
- 5' vrna end - vrna loop (40-mer) (12 kDa, RNA from Tilapia lake virus)
- Tilapia lake virus polymerase (Complex from Tilapia lake virus)
- Putative pb1 (57 kDa, Protein from Tilapia lake virus)
- Rna-dependent rna polymerase (53 kDa, Protein from Tilapia lake virus)
- Transcription-like product (6 kDa, RNA from Tilapia lake virus)
- Magnesium ion (24 Da, Ligand)
- [(2~{r},3~{s},4~{r},5~{r})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{n}-[oxidanyl(phosphonooxy)phosphoryl]phosphonamidic acid (482 Da, Ligand)
- Polymerase acidic protein (pa-like) (47 kDa, Protein from Tilapia lake virus)