Huntingtin C-HEAT domain in complex with HAP40
Alteen MG, Deme JC, Alvarez CP, Loppnau P, Hutchinson A, Seitova A, Chandrasekaran R, Silva Ramos E, Secker C, Alqazzaz M, Wanker EE, Lea SM, Arrowsmith CH, Harding RJ
bioRxiv (2022) [ DOI: doi:10.1101/2022.11.21.516512 ]
Full-length Huntingtin-HAP40 complex from subdomain fragments
Alteen MG, Deme JC, Alvarez CP, Loppnau P, Hutchinson A, Seitova A, Chandrasekaran R, Silva Ramos E, Secker C, Alqazzaz M, Wanker EE, Lea SM, Arrowsmith CH, Harding RJ
bioRxiv (2022) [ DOI: doi:10.1101/2022.11.21.516512 ]
Structure of human excitatory amino acid transporter 3 (EAAT3) in complex with HIP-B
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 7nsg
Q-score: 0.539
Baronina A, Pike ACW, Yu X, Dong YY, Shintre CA, Tessitore A, Chu A, Rotty B, Venkaya S, Mukhopadhyay SMM, Borkowska O, Chalk R, Shrestha L, Burgess-Brown NA, Edwards AM, Arrowsmith CH, Bountra C, Han S, Carpenter EP
To Be Published
- (-)-3-hydroxy-4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (172 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Excitatory amino acid transporter 3 (53 kDa, Protein from Homo sapiens)
- (+)-3-hydroxy-4,5,6,6a-tetrahydro-3ah-pyrrolo[3,4-d]isoxazole-6-carboxylic acid (172 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Ternary complex of excitatory amino acid transporter 3 with inhibitor hip-b (160 kDa, Complex from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7yxx
Q-score: 0.258
Halabelian L, Deme JC, Lea SM, Arrowsmith CH, Structural Genomics Consortium (SGC)
To Be Published
- Probable ubiquitin carboxyl-terminal hydrolase faf-x (293 kDa, Protein from Homo sapiens)
- Trimer of usp9x (Complex from Homo sapiens)
Cryo-EM structure of USP9X, local refinement of monomer
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7yxy
Q-score: 0.344
Halabelian L, Deme JC, Lea SM, Arrowsmith CH, Structural Genomics Consortium (SGC)
To Be Published
High resolution cryoEM structure of huntingtin in complex with HAP40
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6x9o
Q-score: 0.579
Harding RJ, Deme JC, Hevler JF, Tamara S, Lemak A, Cantle JP, Szewczyk MM, Begeja N, Goss S, Zuo X, Loppnau P, Seitova A, Hutchinson A, Fan L, Truant R, Schapira M, Carroll JB, Heck AJR, Lea SM, Arrowsmith CH
Commun Biol (2021) 4 pp. 1374-1374 [ DOI: doi:10.1038/s42003-021-02895-4 Pubmed: 34880419 ]
- Human huntingtin-hap40 complex (Complex from Homo sapiens)
- 40-kda huntingtin-associated protein (41 kDa, Protein from Homo sapiens)
- Huntingtin (349 kDa, Protein from Homo sapiens)
Structure of Human Potassium Chloride Transporter KCC3 in NaCl
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 6y5r
Q-score: 0.461
Chi G, Man H, Ebenhoch R, Reggiano G, Pike ACW, Wang D, McKinley G, Mukhopadhyay SMM, Chalk R, Moreau C, Snee M, Bohstedt T, Singh NK, Abrusci P, Arrowsmith CH, Bountra C, Edwards AM, Marsden BD, Burgess-Brown NA, DiMaio F, Duerr KL, Structural Genomics Consortium (SGC)
To Be Published
- Homodimeric complex of human potassium chloride transporter (246 kDa, Complex from Homo sapiens)
- Solute carrier family 12 member 6 (122 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6gyn
Q-score: 0.479
Shintre CA, Pike ACW, Tessitore A, Young M, Bushell SR, Strain-Damerell C, Mukhopadhyay S, Burgess-Brown NA, Huiskonen JT, Arrowsmith CH, Edwards AM, Bountra C, Carpenter EP
To Be Published
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (60 kDa, Protein from Homo sapiens)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 4 (Cellular component from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)