Huntingtin C-HEAT domain in complex with HAP40
Alteen MG, Deme JC, Alvarez CP, Loppnau P, Hutchinson A, Seitova A, Chandrasekaran R, Silva Ramos E, Secker C, Alqazzaz M, Wanker EE, Lea SM, Arrowsmith CH, Harding RJ
bioRxiv (2022) [ DOI: doi:10.1101/2022.11.21.516512 ]
Full-length Huntingtin-HAP40 complex from subdomain fragments
Alteen MG, Deme JC, Alvarez CP, Loppnau P, Hutchinson A, Seitova A, Chandrasekaran R, Silva Ramos E, Secker C, Alqazzaz M, Wanker EE, Lea SM, Arrowsmith CH, Harding RJ
bioRxiv (2022) [ DOI: doi:10.1101/2022.11.21.516512 ]
High resolution cryoEM structure of huntingtin in complex with HAP40
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 6x9o
Q-score: 0.579
Harding RJ, Deme JC, Hevler JF, Tamara S, Lemak A, Cantle JP, Szewczyk MM, Begeja N, Goss S, Zuo X, Loppnau P, Seitova A, Hutchinson A, Fan L, Truant R, Schapira M, Carroll JB, Heck AJR, Lea SM, Arrowsmith CH
Commun Biol (2021) 4 pp. 1374-1374 [ DOI: doi:10.1038/s42003-021-02895-4 Pubmed: 34880419 ]
- Human huntingtin-hap40 complex (Complex from Homo sapiens)
- 40-kda huntingtin-associated protein (41 kDa, Protein from Homo sapiens)
- Huntingtin (349 kDa, Protein from Homo sapiens)
Structure of Human Potassium Chloride Transporter KCC3 in NaCl
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 6y5r
Q-score: 0.461
Chi G, Man H, Ebenhoch R, Reggiano G, Pike ACW, Wang D, McKinley G, Mukhopadhyay SMM, Chalk R, Moreau C, Snee M, Bohstedt T, Singh NK, Abrusci P, Arrowsmith CH, Bountra C, Edwards AM, Marsden BD, Burgess-Brown NA, DiMaio F, Duerr KL, Structural Genomics Consortium (SGC)
To Be Published
- Homodimeric complex of human potassium chloride transporter (246 kDa, Complex from Homo sapiens)
- Solute carrier family 12 member 6 (122 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6gyn
Q-score: 0.479
Shintre CA, Pike ACW, Tessitore A, Young M, Bushell SR, Strain-Damerell C, Mukhopadhyay S, Burgess-Brown NA, Huiskonen JT, Arrowsmith CH, Edwards AM, Bountra C, Carpenter EP
To Be Published
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (60 kDa, Protein from Homo sapiens)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 4 (Cellular component from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6gyo
Q-score: 0.502
Shintre CA, Pike ACW, Tessitore A, Young M, Bushell SR, Strain-Damerell C, Mukhopadhyay S, Burgess-Brown NA, Huiskonen JT, Arrowsmith CH, Edwards AM, Bountra C, Carpenter EP
To Be Published
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 4 (Cellular component from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Adenosine-3',5'-cyclic-monophosphate (329 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (60 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphoinositol (836 Da, Ligand)
- Unknown atom or ion (65 Da, Ligand)
RNF169 chromatin binding region bound to a ubiquitylated nucleosome
Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE
eLife (2017) 6 [ Pubmed: 28406400 DOI: doi:10.7554/eLife.23872 ]
- Rnf169/ncp-ub complex (230 MDa, Complex)
- Rnf169 miu-lrm region (10 MDa, Complex from Homo sapiens)
- H2ak13 ubiquitylated nucleosome core particle (220 MDa, Complex from Drosophila melanogaster)
Nucleosome core particle Ubiquitylated at H2A Lys-13
Kitevski-LeBlanc J, Fradet-Turcotte A, Kukic P, Wilson MD, Portella G, Yuwen T, Panier S, Duan S, Canny MD, van Ingen H, Arrowsmith CH, Rubinstein JL, Vendruscolo M, Durocher D, Kay LE
eLife (2017) 6 [ Pubmed: 28406400 DOI: doi:10.7554/eLife.23872 ]
- Ncp-ub complex (Complex)
- H2ak13 ubiquitylated nucleosome core particle (220 MDa, Complex from Drosophila)