Alpha7-nicotinic acetylcholine receptor time resolved resting state
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8v89
Q-score: 0.647
Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE
Cell (2024) 187 pp. 1160-1176.e21 [ DOI: doi:10.1016/j.cell.2024.01.032 Pubmed: 38382524 ]
- Hexadecane (226 Da, Ligand)
- Neuronal acetylcholine receptor subunit alpha-7,soluble cytochrome b562 (67 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Alpha7-nicotinic acetylcholine receptor time resolved resting state (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.19 Å
EM Method: Single-particle
Fitted PDBs: 8v8a
Q-score: 0.712
Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE
Cell (2024) 187 pp. 1160-1176.e21 [ DOI: doi:10.1016/j.cell.2024.01.032 Pubmed: 38382524 ]
- Neuronal acetylcholine receptor subunit alpha-7,soluble cytochrome b562 (67 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- (3beta,14beta,17beta,25r)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en (544 Da, Ligand)
- Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and pnu-120596 desensitized intermediate state (Complex from Homo sapiens)
- N-(5-chloro-2,4-dimethoxyphenyl)-n'-(5-methyl-3-isoxazolyl)-urea (311 Da, Ligand)
- Epibatidine (208 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8v8c
Q-score: 0.479
Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE
Cell (2024) 187 pp. 1160-1176.e21 [ DOI: doi:10.1016/j.cell.2024.01.032 Pubmed: 38382524 ]
- Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and pnu-120596 asymmetric state 1 (Complex from Homo sapiens)
- Neuronal acetylcholine receptor subunit alpha-7,soluble cytochrome b562 (67 kDa, Protein from Homo sapiens)
- N-(5-chloro-2,4-dimethoxyphenyl)-n'-(5-methyl-3-isoxazolyl)-urea (311 Da, Ligand)
- Epibatidine (208 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.31 Å
EM Method: Single-particle
Fitted PDBs: 8v8d
Q-score: 0.467
Burke SM, Avstrikova M, Noviello CM, Mukhtasimova N, Changeux JP, Thakur GA, Sine SM, Cecchini M, Hibbs RE
Cell (2024) 187 pp. 1160-1176.e21 [ DOI: doi:10.1016/j.cell.2024.01.032 Pubmed: 38382524 ]
- Neuronal acetylcholine receptor subunit alpha-7,soluble cytochrome b562 (67 kDa, Protein from Homo sapiens)
- Alpha7-nicotinic acetylcholine receptor time resolved bound to epibatidine and pnu-120596 asymmetric state 2 (Complex from Homo sapiens)
- N-(5-chloro-2,4-dimethoxyphenyl)-n'-(5-methyl-3-isoxazolyl)-urea (311 Da, Ligand)
- Epibatidine (208 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)