Catalytic domain of human DNA polymerase alpha in complex with DNA and RPA
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 9mj5
Q-score: 0.436
Baranovskiy AG, Morstadt LM, Romero EE, Babayeva ND, Tahirov TH
To Be Published
- Dna template (35-mer) (10 kDa, DNA from Homo sapiens)
- Replication protein a 14 kda subunit (13 kDa, Protein from Homo sapiens)
- Ternary complex of dna polymerase alpha with dna and replication protein a (Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
- Replication protein a 70 kda dna-binding subunit (21 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- 2'-deoxycytidine-5'-triphosphate (467 Da, Ligand)
- Dna polymerase alpha catalytic subunit (103 kDa, Protein from Homo sapiens)
- Replication protein a 32 kda subunit (25 kDa, Protein from Homo sapiens)
- Rna-dna primer (11-mer) (3 kDa, Macromolecule from Homo sapiens)
Movies for human polymerase alpha-primase in DNA elongation states
He Q, Baranovskiy AG, Morstadt LM, Lisova AE, Babayeva ND, Lusk BL, Lim CJ, Tahirov TH
Nat Struct Mol Biol (2023) [ DOI: 10.1038/s41594-023-00971-3 Pubmed: 37069376 ]
Image sets:
Human DNA polymerase alpha/primase elongation complex I bound to primer/template
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8d96
Q-score: 0.426
He Q, Baranovskiy AG, Morstadt LM, Lisova AE, Babayeva ND, Lusk BL, Lim CJ, Tahirov TH
Nat Struct Mol Biol (2023) 30 pp. 579-583 [ Pubmed: 37069376 DOI: doi:10.1038/s41594-023-00971-3 ]
- Magnesium ion (24 Da, Ligand)
- Iron/sulfur cluster (351 Da, Ligand)
- Dna/rna (5'-gtp)-r(p*gp*cp*gp*gp*cp*ap*cp*g)-d(p*ap*cp*c)-3') (3 kDa, Macromolecule from Homo sapiens)
- Elongation complex i of human dna polymerase alpha/primase bound to rna-dna primer and dna template (340 kDa, Complex from Homo sapiens)
- Dna polymerase alpha catalytic subunit (166 kDa, Protein from Homo sapiens)
- Dna (5'-d(*ap*tp*ap*ap*tp*gp*gp*tp*cp*gp*tp*gp*cp*cp*gp*cp*cp*ap*ap*tp*ap*a)-3') (6 kDa, DNA from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- Dna primase large subunit (58 kDa, Protein from Homo sapiens)
Human DNA polymerase-alpha/primase elongation complex II bound to primer/template
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8d9d
Q-score: 0.347
He Q, Baranovskiy AG, Morstadt LM, Lisova AE, Babayeva ND, Lusk BL, Lim CJ, Tahirov TH
Nat Struct Mol Biol (2023) 30 pp. 579-583 [ Pubmed: 37069376 DOI: doi:10.1038/s41594-023-00971-3 ]
- Magnesium ion (24 Da, Ligand)
- Dna/rna (5'-d(*(gtp))-r(p*gp*cp*gp*gp*cp*ap*cp*g)-d(p*ap*cp*c)-3') (3 kDa, Macromolecule from Homo sapiens)
- Elongation complex ii of human dna polymerase alpha/primase bound to rna-dna primer and dna template (340 kDa, Complex from Homo sapiens)
- Dna (5'-d(*ap*tp*gp*gp*tp*cp*gp*tp*gp*cp*cp*gp*cp*cp*ap*ap*tp*ap*a)-3') (5 kDa, DNA from Homo sapiens)
- Dna primase small subunit (49 kDa, Protein from Homo sapiens)
- Iron/sulfur cluster (351 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dna polymerase alpha catalytic subunit (166 kDa, Protein from Homo sapiens)
- 2'-deoxyadenosine 5'-triphosphate (491 Da, Ligand)
- Dna polymerase alpha subunit b (49 kDa, Protein from Homo sapiens)
- Dna primase large subunit (58 kDa, Protein from Homo sapiens)