Human SCNN1D-SCNN1B-SCNN1G ENaC trimer
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 9blr
Q-score: 0.459
Structure (2025) 33 pp. 349-362.e4 [ DOI: doi:10.1016/j.str.2024.11.013 Pubmed: 39667931 ]
- Human delta subunit isoform 1 (70 MDa, Complex from Homo sapiens)
- Human gamma subunit isoform 1 (74 MDa, Complex from Homo sapiens)
- Human beta subunit isoform 1 (72 MDa, Complex from Homo sapiens)
- Amiloride-sensitive sodium channel subunits delta, beta, and gamma (Cell)
- Amiloride-sensitive sodium channel subunit gamma (74 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amiloride-sensitive sodium channel subunit beta (72 kDa, Protein from Homo sapiens)
- Isoform 1 of amiloride-sensitive sodium channel subunit delta (70 kDa, Protein from Homo sapiens)
Human SCNN1B-SCNN1B-SCNN1G ENaC trimer
Resolution: 3.12 Å
EM Method: Single-particle
Fitted PDBs: 9btg
Q-score: 0.523
Structure (2025) 33 pp. 349-362.e4 [ DOI: doi:10.1016/j.str.2024.11.013 Pubmed: 39667931 ]
- Human gamma subunit isoform 1 (Complex from Homo sapiens)
- Amiloride-sensitive sodium channel subunits delta, beta, and gamma (Cell)
- Amiloride-sensitive sodium channel subunit gamma (74 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amiloride-sensitive sodium channel subunit beta (72 kDa, Protein from Homo sapiens)
- Human beta subunit isoform 1 (Complex from Homo sapiens)
Human SCNN1B-SCNN1G ENaC dimers
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 9btu
Q-score: 0.42
Structure (2025) 33 pp. 349-362.e4 [ DOI: doi:10.1016/j.str.2024.11.013 Pubmed: 39667931 ]
- Amiloride-sensitive sodium channel subunit gamma (74 kDa, Protein from Homo sapiens)
- Amiloride-sensitive sodium channel subunits beta, and gamma in complex with 10d4 fab (Complex)
- Human gamma subunit isoform 1 (Complex from Homo sapiens)
- 10d4 fab (9 kDa, Protein from Mus musculus)
- Fab fragment from 10d4 igg (Complex from Homo sapiens)
- Amiloride-sensitive sodium channel subunit beta (72 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 10d4 fab (6 kDa, Protein from Mus musculus)
- Human beta subunit isoform 1 (Complex from Homo sapiens)
Map of an acid-sensing ion channel in a desensitized state after photo-uncaging protons.
Yoder N, Jalali-Yazdi F, Noreng S, Houser A, Baconguis I, Gouaux E
J Struct Biol (2020) 212 pp. 107624-107624 [ DOI: doi:10.1016/j.jsb.2020.107624 Pubmed: 32950604 ]
- Acid-sensing ion channel (180 kDa, Complex from Gallus gallus)
- Acid-sensing ion channel (Protein from Gallus gallus)
Map of an acid-sensing ion channel in a resting state at high pH.
Yoder N, Jalali-Yazdi F, Noreng S, Houser A, Baconguis I, Gouaux E
J Struct Biol (2020) 212 pp. 107624-107624 [ DOI: doi:10.1016/j.jsb.2020.107624 Pubmed: 32950604 ]
- Acid-sensing ion channel 1 (180 kDa, Complex from Gallus gallus)
- Acid-sensing ion channel 1 (Protein from Gallus gallus)
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 6wth
Q-score: 0.521
Noreng S, Posert R, Bharadwaj A, Houser A, Baconguis I
eLife (2020) 9 [ DOI: doi:10.7554/eLife.59038 Pubmed: 32729833 ]
- Amiloride-sensitive sodium channel subunit gamma (74 kDa, Protein from Homo sapiens)
- Amiloride-sensitive sodium channel subunit alpha (75 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Full-length human enac heterotrimer bound with two high-affinity fabs (320 kDa, Complex from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- 7b1 fab (10 kDa, Protein from Mus musculus)
- Amiloride-sensitive sodium channel subunit beta (72 kDa, Protein from Homo sapiens)
- 10d4 fab (9 kDa, Protein from Mus musculus)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6bqn
Q-score: 0.305
Noreng S, Bharadwaj A, Posert R, Yoshioka C, Baconguis I
eLife (2018) 7 [ DOI: doi:10.7554/eLife.39340 Pubmed: 30251954 ]
- Membrane protein complex (Cell from Homo sapiens)
- Scnn1b (55 kDa, Protein from Homo sapiens)
- 10d4 fab (9 kDa, Protein from Mus musculus)
- 7b1 fab (10 kDa, Protein from Mus musculus)
- Egfp-scnn1g chimera (55 kDa, Protein from Homo sapiens)
- 10d4 fab (9 kDa, Protein from Mus musculus)
- Scnn1a (54 kDa, Protein from Homo sapiens)
- 7b1 fab (9 kDa, Protein from Mus musculus)
Resolution: 7.3 Å
EM Method: Single-particle
Fitted PDBs: 5kk2
Q-score: 0.207
Zhao Y, Chen S, Yoshioka C, Baconguis I, Gouaux E
Nature (2016) 536 pp. 108-111 [ DOI: doi:10.1038/nature18961 Pubmed: 27368053 ]