Faull SV, Elliston ELK, Gooptu B, Jagger AM, Aldobiyan I, Redzej A, Badaoui M, Heyer-Chauhan N, Rashid ST, Reynolds GM, Adams DH, Miranda E, Orlova EV, Irving JA, Lomas DA
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1370 Pubmed: 33087346 ]
- Complex between two 4b12 fab fragments and a dimer component of polymers induced by heating of the wild-type m alpha-1 antitrypsin variant (200 kDa, Complex from Homo sapiens)
- Alpha-1 antitrypsin (Protein from Homo sapiens)
- Polymers induced by heating monomeric wild-type alpha-1 antitrypsin and labelled with 4b12 fab fragments (Tissue from Homo sapiens)
- 4b12 fab heavy chain (Protein from Mus musculus)
- 4b12 fab light chain (Protein from Mus musculus)
Faull SV, Elliston ELK, Gooptu B, Jagger AM, Aldobiyan I, Redzej A, Badaoui M, Heyer-Chauhan N, Rashid ST, Reynolds GM, Adams DH, Miranda E, Orlova EV, Irving JA, Lomas DA
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1370 Pubmed: 33087346 ]
- Polymers of the severe deficiency z variant of alpha-1 antitrypsin labelled with 4b12 fab fragments (Tissue from Homo sapiens)
- Complex between two 4b12 fab fragments and a dimer component of polymers of the severe deficiency z alpha-1 antitrypsin variant (200 kDa, Complex from Homo sapiens)
- Alpha-1 antitrypsin (Protein from Homo sapiens)
- 4b12 fab heavy chain (Protein from Mus musculus)
- 4b12 fab light chain (Protein from Mus musculus)
Faull SV, Elliston ELK, Gooptu B, Jagger AM, Aldobiyan I, Redzej A, Badaoui M, Heyer-Chauhan N, Rashid ST, Reynolds GM, Adams DH, Miranda E, Orlova EV, Irving JA, Lomas DA
Sci Adv (2020) 6 [ DOI: doi:10.1126/sciadv.abc1370 Pubmed: 33087346 ]
- Polymers of the severe deficiency z variant of alpha-1 antitrypsin labelled with 4b12 fab fragments (Tissue from Homo sapiens)
- Complex between two 4b12 fab fragments and a dimer component of polymers of the severe deficiency z alpha-1 antitrypsin variant (200 kDa, Complex from Homo sapiens)
- Alpha-1 antitrypsin (Protein from Homo sapiens)
- 4b12 fab heavy chain (Protein from Mus musculus)
- 4b12 fab light chain (Protein from Mus musculus)
Resolution: 3.36 Å
EM Method: Single-particle
Fitted PDBs: 6rwl
Q-score: 0.471
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
- Sivrcm intasome in complex with bictegravir (Complex)
- Zinc ion (65 Da, Ligand)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Pol protein (Complex from Simian immunodeficiency virus)
SIVrcm intasome in complex with bictegravir
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 6rwm
Q-score: 0.563
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
- Sivrcm intasome in complex with bictegravir (Complex)
- Zinc ion (65 Da, Ligand)
- Water (18 Da, Ligand)
- Bictegravir (449 Da, Ligand)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Magnesium ion (24 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pol protein (Complex from Simian immunodeficiency virus)
SIVrcm intasome in complex with dolutegravir
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6rwn
Q-score: 0.524
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- (4r,12as)-n-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2h-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide (419 Da, Ligand)
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
- Zinc ion (65 Da, Ligand)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Magnesium ion (24 Da, Ligand)
- Pol protein (Complex from Simian immunodeficiency virus)
- Sivrcm intasome in complex with dolutegravir (Complex)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
SIVrcm intasome (Q148H/G140S) in complex with bictegravir
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 6rwo
Q-score: 0.538
Cook NJ, Li W, Berta D, Badaoui M, Ballandras-Colas A, Nans A, Kotecha A, Rosta E, Engelman AN, Cherepanov P
Science (2020) 367 pp. 806-810 [ Pubmed: 32001525 DOI: doi:10.1126/science.aay4919 ]
- Dna (5'-d(p*gp*cp*tp*ap*ap*gp*ap*ap*ap*ap*ap*tp*cp*tp*cp*tp*ap*cp*cp*a)-3') (9 kDa, DNA from Simian immunodeficiency virus)
- Dna (Complex from Simian immunodeficiency virus)
- Sivrcm intasome in complex with bictegravir (Complex)
- Pol protein (32 kDa, Protein from Simian immunodeficiency virus)
- Zinc ion (65 Da, Ligand)
- Bictegravir (449 Da, Ligand)
- Water (18 Da, Ligand)
- Dna (5'-d(*ap*ap*cp*tp*gp*gp*tp*ap*gp*ap*gp*ap*tp*tp*tp*tp*tp*cp*tp*tp*ap*gp*c)-3') (10 kDa, DNA from Simian immunodeficiency virus)
- Magnesium ion (24 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Pol protein (Complex from Simian immunodeficiency virus)