Structure of human SARS-CoV-2 neutralizing antibody C1C-A3 Fab
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 7sn2
Q-score: 0.399
Nabel KG, Clark SA, Shankar S, Pan J, Clark LE, Yang P, Coscia A, McKay LGA, Varnum HH, Brusic V, Tolan NV, Zhou G, Desjardins M, Turbett SE, Kanjilal S, Sherman AC, Dighe A, LaRocque RC, Ryan ET, Tylek C, Cohen-Solal JF, Darcy AT, Tavella D, Clabbers A, Fan Y, Griffiths A, Correia IR, Seagal J, Baden LR, Charles RC, Abraham J
Science (2022) 375 pp. eabl6251-eabl6251 [ Pubmed: 34855508 DOI: doi:10.1126/science.abl6251 ]
- Sars-cov-2 spike protein sars-cov-2 hexapro (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2_hexapro in complex with neutralizing antibody c1c-a3 fab from human patient (50 kDa, Complex from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody c1c-a3 fab light chain (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody c1c-a3 fab heavy chain (27 kDa, Protein from Homo sapiens)
- C1c-a3 fab (Complex from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7sn3
Q-score: 0.451
Nabel KG, Clark SA, Shankar S, Pan J, Clark LE, Yang P, Coscia A, McKay LGA, Varnum HH, Brusic V, Tolan NV, Zhou G, Desjardins M, Turbett SE, Kanjilal S, Sherman AC, Dighe A, LaRocque RC, Ryan ET, Tylek C, Cohen-Solal JF, Darcy AT, Tavella D, Clabbers A, Fan Y, Griffiths A, Correia IR, Seagal J, Baden LR, Charles RC, Abraham J
Science (2022) 375 pp. eabl6251-eabl6251 [ Pubmed: 34855508 DOI: doi:10.1126/science.abl6251 ]
- C1c-a3 fab (variable region) (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neutralizing antibody c1c-a3 light chain variable region (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein trimer in complex with human patient antibody c1c-a3 fab (50 kDa, Complex from Homo sapiens)
- Neutralizing antibody c1c-a3 heavy chain variable region (27 kDa, Protein from Homo sapiens)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7m6e
Q-score: 0.394
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Bg10-19 fab light chain (22 kDa, Protein from Homo sapiens)
- Bg10-19 fab heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ternary complex of bg10-19 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Bg10-19 fab (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7m6f
Q-score: 0.32
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg1-22 fab light chain (22 kDa, Protein from Homo sapiens)
- Bg1-22 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ternary complex of bg1-22 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Bg1-22 fab (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7m6g
Q-score: 0.317
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- Ternary complex of bg7-15 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Bg7-15 fab light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg7-15 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Bg7-15 fab (Complex from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7m6h
Q-score: 0.254
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg7-20 fab (Complex from Homo sapiens)
- Bg7-20 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ternary complex of bg7-20 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Bg7-20 fab light chain (22 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7m6i
Q-score: 0.277
Scheid JF, Barnes CO, Eraslan B, Hudak A, Keeffe JR, Cosimi LA, Brown EM, Muecksch F, Weisblum Y, Zhang S, Delorey T, Woolley AE, Ghantous F, Park SM, Phillips D, Tusi B, Huey-Tubman KE, Cohen AA, Gnanapragasam PNP, Rzasa K, Hatziioanno T, Durney MA, Gu X, Tada T, Landau NR, West Jr AP, Rozenblatt-Rosen O, Seaman MS, Baden LR, Graham DB, Deguine J, Bieniasz PD, Regev A, Hung D, Bjorkman PJ, Xavier RJ
Cell (2021) 184 pp. 3205- [ DOI: doi:10.1016/j.cell.2021.04.032 Pubmed: 34015271 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg1-24 fab light chain (23 kDa, Protein from Homo sapiens)
- Ternary complex of bg1-24 fab bound to sars-cov-2 spike trimer (720 kDa, Complex)
- Bg1-24 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Bg1-24 fab (Complex from Homo sapiens)
- Sars-cov-2 spike trimer (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (139 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)