Structure of mouse C5a-human C5aR1-Go complex
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8jzp
Q-score: 0.438
Yadav MK, Yadav R, Maharana J, Sarma P, Banerjee R, Shukla AK, Gati C
To Be Published
- Antibody fragment scfv16 (26 kDa, Protein from Mus musculus)
- Antibody fragment - scfv16 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Complement c5a (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Mouse c5a-human c5ar1-go complex (Complex)
- C5a anaphylatoxin chemotactic receptor 1 (45 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Homo sapiens)
- C5a anaphylatoxin (12 kDa, Protein from Mus musculus)
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 8jps
Q-score: 0.353
Saha S, Khanppnavar B, Maharana J, Kim H, Carino CMC, Daly C, Houston S, Sharma S, Zaidi N, Dalal A, Mishra S, Ganguly M, Tiwari D, Kumari P, Jhingan GD, Yadav PN, Plouffe B, Inoue A, Chung KY, Banerjee R, Korkhov VM, Shukla AK
Cell (2024) 187 pp. 4751-4769.e25 [ DOI: doi:10.1016/j.cell.2024.07.005 Pubmed: 39089252 ]
- Duffy antigen receptor for chemokines (darc)/ackr1 in complex with the chemokine, ccl7 (Complex from Homo sapiens)
- Duffy antigen receptor for chemokines (darc)/ackr1 (Complex)
- C-c motif chemokine 7 (7 kDa, Protein from Homo sapiens)
- Ccl7 (Complex)
- Atypical chemokine receptor 1 (28 kDa, Protein from Homo sapiens)
Saha S, Khanppnavar B, Maharana J, Kim H, Carino CMC, Daly C, Houston S, Sharma S, Zaidi N, Dalal A, Mishra S, Ganguly M, Tiwari D, Kumari P, Jhingan GD, Yadav PN, Plouffe B, Inoue A, Chung KY, Banerjee R, Korkhov VM, Shukla AK
Cell (2024) 187 pp. 4751-4769.e25 [ DOI: doi:10.1016/j.cell.2024.07.005 Pubmed: 39089252 ]
Saha S, Khanppnavar B, Maharana J, Kim H, Carino CMC, Daly C, Houston S, Sharma S, Zaidi N, Dalal A, Mishra S, Ganguly M, Tiwari D, Kumari P, Jhingan GD, Yadav PN, Plouffe B, Inoue A, Chung KY, Banerjee R, Korkhov VM, Shukla AK
Cell (2024) 187 pp. 4751-4769.e25 [ DOI: doi:10.1016/j.cell.2024.07.005 Pubmed: 39089252 ]
Structure of Niacin-GPR109A-G protein complex
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8iy9
Q-score: 0.494
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Structure of gpr109a-g protein in complex with niacin (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Scfv16 (antibody fragment) (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
Structure of MK6892-GPR109A-G-protein complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8iyh
Q-score: 0.498
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Structure of mk6892-gpr109a-g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 antibody (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
Structure of GSK256073-GPR109A-G-protein complex
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8iyw
Q-score: 0.469
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- 8-chloranyl-3-pentyl-7h-purine-2,6-dione (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Structure of gsk256073-gpr109a-g-protein complex (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Scfv16 antibody fragment (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
Structure of Acipimox-GPR109A-G protein complex
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8jer
Q-score: 0.468
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Scfv16 antibody fragment (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid (155 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Acipimox-gpr109a-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
Structure of MMF-GPR109A-G protein complex
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8jhn
Q-score: 0.441
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Guanine nucleotide-binding protein g(i)/g(s) /g(t) subunit beta-1 (Complex from Homo sapiens)
- Scfv16 (antibody) (Complex from Mus musculus)
- G protein subunit alpha o1,guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
- Gpr109a-g protein in complex with mmf (Complex from Homo sapiens)
- Monomethyl fumarate (130 Da, Ligand)
- Hydrocarboxylic acid receptor 2/gpr109a (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (antibody) (26 kDa, Protein from Mus musculus)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8go9
Q-score: 0.46
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ DOI: doi:10.1126/science.adj3347 Pubmed: 38175886 ]
- Fab30 (Complex from Mus musculus)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
- Beta-arrestin-2 (47 kDa, Protein from Bos taurus)
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Beta-arrestin2 (Complex from Bos taurus)
- Atypical chemokine receptor 2 (Complex from Homo sapiens)
- Atypical chemokine receptor 2 (2 kDa, Protein from Homo sapiens)
- Peptide bound beta-arrestin2 in complex with fab30 (190 kDa, Complex)