Structure of Niacin-GPR109A-G protein complex
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8iy9
Q-score: 0.494
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (antibody fragment) (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Structure of gpr109a-g protein in complex with niacin (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of MK6892-GPR109A-G-protein complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8iyh
Q-score: 0.498
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Scfv16 antibody (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Structure of mk6892-gpr109a-g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of GSK256073-GPR109A-G-protein complex
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8iyw
Q-score: 0.469
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- 8-chloranyl-3-pentyl-7h-purine-2,6-dione (256 Da, Ligand)
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Structure of gsk256073-gpr109a-g-protein complex (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Scfv16 antibody fragment (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of Acipimox-GPR109A-G protein complex
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8jer
Q-score: 0.468
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid (155 Da, Ligand)
- Scfv16 antibody fragment (26 kDa, Protein from Mus musculus)
- Acipimox-gpr109a-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of MMF-GPR109A-G protein complex
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8jhn
Q-score: 0.441
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 (antibody) (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Gpr109a-g protein in complex with mmf (Complex from Homo sapiens)
- Hydrocarboxylic acid receptor 2/gpr109a (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (antibody) (Complex from Mus musculus)
- G protein subunit alpha o1,guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s) /g(t) subunit beta-1 (Complex from Homo sapiens)
- Monomethyl fumarate (130 Da, Ligand)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8go9
Q-score: 0.46
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ DOI: doi:10.1126/science.adj3347 Pubmed: 38175886 ]
- Fab30 (Complex from Mus musculus)
- Peptide bound beta-arrestin2 in complex with fab30 (190 kDa, Complex)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
- Atypical chemokine receptor 2 (Complex from Homo sapiens)
- Beta-arrestin-2 (47 kDa, Protein from Bos taurus)
- Beta-arrestin2 (Complex from Bos taurus)
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Atypical chemokine receptor 2 (2 kDa, Protein from Homo sapiens)
Structure of beta-arrestin2 in complex with M2Rpp
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 8j8r
Q-score: 0.543
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ DOI: doi:10.1126/science.adj3347 Pubmed: 38175886 ]
- Beta-arrestin2 in complex with m2rpp (Complex)
- Fab30 (Complex from Mus musculus)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
- Beta-arrestin-2 (47 kDa, Protein from Bos taurus)
- Beta-arrestin2 (Complex from Bos taurus)
- Muscarinic acetylcholine receptor m2 (2 kDa, Protein from Homo sapiens)
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Muscarinic receptor m2r (Complex from Homo sapiens)
Structure of beta-arrestin2 in complex with D6Rpp (Local Refine)
Resolution: 3.22 Å
EM Method: Single-particle
Fitted PDBs: 8j8v
Q-score: 0.514
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ DOI: doi:10.1126/science.adj3347 Pubmed: 38175886 ]
- Fab30 (Complex from Mus musculus)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
- Atypical chemokine receptor 2 (Complex from Homo sapiens)
- Beta-arrestin-2 (47 kDa, Protein from Bos taurus)
- Beta-arrestin2 in complex with d6rpp (Complex)
- Beta-arrestin2 (Complex from Bos taurus)
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Atypical chemokine receptor 2 (2 kDa, Protein from Homo sapiens)
Structure of beta-arrestin1 in complex with D6Rpp
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8j8z
Q-score: 0.489
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ DOI: doi:10.1126/science.adj3347 Pubmed: 38175886 ]
- Beta-arrestin1 in complex with d6rpp (Complex)
- Beta-arrestin-1 (47 kDa, Protein from Rattus norvegicus)
- Fab30 heavy chain (25 kDa, Protein from Mus musculus)
- Beta-arrestin-1 (Complex from Rattus norvegicus)
- Atypical chemokine receptor 2 (2 kDa, Protein from Homo sapiens)
- Fab30 heavy chain (Complex from Mus musculus)
- Fab30 light chain (Complex from Mus musculus)
- Fab30 light chain (23 kDa, Protein from Mus musculus)
- Phosphopeptide derived from the c-terminal tail of ackr2 (d6r) receptor (Complex from Homo sapiens)
Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local refine, cross-linked)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8j97
Q-score: 0.456
Maharana J, Sano FK, Sarma P, Yadav MK, Duan L, Stepniewski TM, Chaturvedi M, Ranjan A, Singh V, Saha S, Mahajan G, Chami M, Shihoya W, Selent J, Chung KY, Banerjee R, Nureki O, Shukla AK
Science (2024) 383 pp. 101-108 [ DOI: doi:10.1126/science.adj3347 Pubmed: 38175886 ]
- Fab30 (Complex from Mus musculus)
- Beta-arrestin1 (Complex from Bos taurus)
- Fab30 heavy chain (12 kDa, Protein from Mus musculus)
- Beta-arrestin-1 (39 kDa, Protein from Bos taurus)
- Muscarinic receptor (m2r) in complex with beta-arrestin1 (Complex)
- Fab30 light chain (11 kDa, Protein from Mus musculus)
- Muscarinic receptor m2r (Complex from Homo sapiens)
- Muscarinic acetylcholine receptor m2 (1 kDa, Protein from Homo sapiens)