Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 8jps
Q-score: 0.353
Saha S, Khanppnavar B, Maharana J, Kim H, Carino CMC, Daly C, Houston S, Sharma S, Zaidi N, Dalal A, Mishra S, Ganguly M, Tiwari D, Kumari P, Jhingan GD, Yadav PN, Plouffe B, Inoue A, Chung KY, Banerjee R, Korkhov VM, Shukla AK
Cell (2024) 187 pp. 4751-4769.e25 [ Pubmed: 39089252 DOI: doi:10.1016/j.cell.2024.07.005 ]
- Duffy antigen receptor for chemokines (darc)/ackr1 in complex with the chemokine, ccl7 (Complex from Homo sapiens)
- Ccl7 (Complex)
- Atypical chemokine receptor 1 (28 kDa, Protein from Homo sapiens)
- C-c motif chemokine 7 (7 kDa, Protein from Homo sapiens)
- Duffy antigen receptor for chemokines (darc)/ackr1 (Complex)
Saha S, Khanppnavar B, Maharana J, Kim H, Carino CMC, Daly C, Houston S, Sharma S, Zaidi N, Dalal A, Mishra S, Ganguly M, Tiwari D, Kumari P, Jhingan GD, Yadav PN, Plouffe B, Inoue A, Chung KY, Banerjee R, Korkhov VM, Shukla AK
Cell (2024) 187 pp. 4751-4769.e25 [ Pubmed: 39089252 DOI: doi:10.1016/j.cell.2024.07.005 ]
Saha S, Khanppnavar B, Maharana J, Kim H, Carino CMC, Daly C, Houston S, Sharma S, Zaidi N, Dalal A, Mishra S, Ganguly M, Tiwari D, Kumari P, Jhingan GD, Yadav PN, Plouffe B, Inoue A, Chung KY, Banerjee R, Korkhov VM, Shukla AK
Cell (2024) 187 pp. 4751-4769.e25 [ Pubmed: 39089252 DOI: doi:10.1016/j.cell.2024.07.005 ]
Structure of Niacin-GPR109A-G protein complex
Resolution: 3.37 Å
EM Method: Single-particle
Fitted PDBs: 8iy9
Q-score: 0.494
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (antibody fragment) (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Structure of gpr109a-g protein in complex with niacin (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Nicotinic acid (123 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of MK6892-GPR109A-G-protein complex
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8iyh
Q-score: 0.498
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Scfv16 antibody (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid (386 Da, Ligand)
- Structure of mk6892-gpr109a-g-protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of GSK256073-GPR109A-G-protein complex
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8iyw
Q-score: 0.469
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- 8-chloranyl-3-pentyl-7h-purine-2,6-dione (256 Da, Ligand)
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Structure of gsk256073-gpr109a-g-protein complex (Complex from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Scfv16 antibody fragment (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of Acipimox-GPR109A-G protein complex
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 8jer
Q-score: 0.468
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 antibody fragment (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid (155 Da, Ligand)
- Scfv16 antibody fragment (26 kDa, Protein from Mus musculus)
- Acipimox-gpr109a-g protein complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Hydroxycarboxylic acid receptor 2/gpr109a (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of MMF-GPR109A-G protein complex
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8jhn
Q-score: 0.441
Yadav MK, Sarma P, Maharana J, Ganguly M, Mishra S, Zaidi N, Dalal A, Singh V, Saha S, Mahajan G, Sharma S, Chami M, Banerjee R, Shukla AK
Nat Commun (2024) 15 pp. 1939-1939 [ DOI: doi:10.1038/s41467-024-46239-2 Pubmed: 38431681 ]
- Scfv16 (antibody) (26 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Gpr109a-g protein in complex with mmf (Complex from Homo sapiens)
- Hydrocarboxylic acid receptor 2/gpr109a (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (antibody) (Complex from Mus musculus)
- G protein subunit alpha o1,guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s) /g(t) subunit beta-1 (Complex from Homo sapiens)
- Monomethyl fumarate (130 Da, Ligand)
- Hydroxycarboxylic acid receptor 2 (47 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of C5a-pep bound mouse C5aR1 in complex with Go
Resolution: 3.39 Å
EM Method: Single-particle
Fitted PDBs: 8hpt
Q-score: 0.491
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Mus musculus)
- Antibody fragment (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Gpcr-g protein in complex with a synthetic peptide agonist (Complex)
- C5a anaphylatoxin chemotactic receptor 1 (44 kDa, Protein from Mus musculus)
- Mea-lys-pro-zal-alc-dar (869 Da, Protein from synthetic construct)
- Antibody fragment scfv16 (27 kDa, Protein from Mus musculus)
- Synthetic peptide (Complex)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)
Structure of a GPCR-G protein in complex with a natural peptide agonist
Resolution: 3.89 Å
EM Method: Single-particle
Fitted PDBs: 8hqc
Q-score: 0.443
Yadav MK, Maharana J, Yadav R, Saha S, Sarma P, Soni C, Singh V, Saha S, Ganguly M, Li XX, Mohapatra S, Mishra S, Khant HA, Chami M, Woodruff TM, Banerjee R, Shukla AK, Gati C
Cell (2023) 186 pp. 4956-4973.e21 [ Pubmed: 37852260 DOI: doi:10.1016/j.cell.2023.09.020 ]
- C5a anaphylatoxin chemotactic receptor 1 (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin chemotactic receptor 1 (44 kDa, Protein from Mus musculus)
- Antibody fragment (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(o) subunit alpha (27 kDa, Protein from Homo sapiens)
- Antibody fragment (27 kDa, Protein from Mus musculus)
- C5a anaphylatoxin (8 kDa, Protein from Homo sapiens)
- C5a anaphylatoxin (Complex from Homo sapiens)
- Gpcr-g protein in complex with a natural peptide agonist (Complex)
- Guanine nucleotide-binding protein g(o) subunit alpha (Complex from Homo sapiens)