Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8th3
Q-score: 0.532
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ DOI: doi:10.1038/s41589-024-01620-6 Pubmed: 38744986 ]
- At118-h nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion, anti-bril fab, and anti-fab nanobody (Complex from Homo sapiens)
- At118-h nanobody, type-1 angiotensin ii receptor, soluble cytochrome b562 complex (65 kDa, Protein from Homo sapiens)
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
- Cholesterol hemisuccinate (486 Da, Ligand)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8th4
Q-score: 0.495
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ DOI: doi:10.1038/s41589-024-01620-6 Pubmed: 38744986 ]
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
- [2-butyl-5-chloranyl-3-[[4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol (422 Da, Ligand)
- At118-l nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion protein, anti-bril fab, anti-fab nanobody, and losartan (Complex from Homo sapiens)
- At118-l nanobody (15 kDa, Protein from synthetic construct)
- Type-1 angiotensin ii receptor soluble cytochrome b562 complex (49 kDa, Protein from Homo sapiens)
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6vms
Q-score: 0.38
Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM
Nature (2020) 584 pp. 125-129 [ Pubmed: 32528175 DOI: doi:10.1038/s41586-020-2379-5 ]
- Endolysin,d(2) dopamine receptor,d(2) dopamine receptor (51 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (9 kDa, Protein from Homo sapiens)
- D2 dopamine receptor-g protein complex (Complex from Homo sapiens)
- Bromoergocryptine (654 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Rattus norvegicus)
- Scfv16 (27 kDa, Protein from Homo sapiens)
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane
Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai X, Sunahara RK, Barth P, Rosenbaum DM
Nature (2020) [ DOI: doi:10.1038/s41586-020-2379-5 ]
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane
Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai X, Sunahara RK, Barth P, Rosenbaum DM
Nature (2020) [ DOI: doi:10.1038/s41586-020-2379-5 ]