Calcitonin Receptor in complex with Gs and Pramlintide analogue peptide San45
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 8f0j
Q-score: 0.621
Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM
Nat Chem Biol (2024) 20 pp. 162-169 [ DOI: doi:10.1038/s41589-023-01393-4 Pubmed: 37537379 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- N-hexadecanoyl-l-glutamic acid (385 Da, Ligand)
- Calcitonin receptor in complex with gs protein and san45 peptide (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Pramlintide analogue san45 (3 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Phosphatidylethanolamine (734 Da, Ligand)
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8f2a
Q-score: 0.556
Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM
Nat Chem Biol (2024) 20 pp. 162-169 [ DOI: doi:10.1038/s41589-023-01393-4 Pubmed: 37537379 ]
- Human amylin 3 receptor in complex with gs protein and san385 peptide in another conformation (cluster 5) (Complex from Homo sapiens)
- Pramlintide analogue san385 (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Receptor activity-modifying protein 3 (16 kDa, Protein from Homo sapiens)
Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45
Resolution: 2.0 Å
EM Method: Single-particle
Fitted PDBs: 8f2b
Q-score: 0.556
Cao J, Belousoff MJ, Gerrard E, Danev R, Fletcher MM, Dal Maso E, Schreuder H, Lorenz K, Evers A, Tiwari G, Besenius M, Li Z, Johnson RM, Wootten D, Sexton PM
Nat Chem Biol (2024) 20 pp. 162-169 [ DOI: doi:10.1038/s41589-023-01393-4 Pubmed: 37537379 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Amylin 3 receptor in complex with gs protein and san45 peptide (Complex from Homo sapiens)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-hexadecanoyl-l-glutamic acid (385 Da, Ligand)
- Pramlintide analogue san45 (3 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Receptor activity-modifying protein 3 (16 kDa, Protein from Homo sapiens)
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7ttw
Q-score: 0.598
Perlaza-Jimenez L, Tan KS, Piper SJ, Johnson RM, Bamert RS, Stubenrauch CJ, Wright A, Lupton D, Lithgow T, Belousoff MJ
Microbiol Spectr (2022) 10 pp. e0058322-e0058322 [ Pubmed: 35736238 DOI: doi:10.1128/spectrum.00583-22 ]
- 50s ribosomal protein l3 (23 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l15 (15 kDa, Protein from Staphylococcus aureus)
- 23s rrna (946 kDa, RNA from Staphylococcus aureus)
- 50s ribosomal protein l33 (5 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l35 (7 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l2 (30 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l24 (11 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l19 (13 kDa, Protein from Staphylococcus aureus)
- 5s rrna (36 kDa, RNA from Staphylococcus aureus)
- 50s ribosomal protein l23 (10 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l17 (13 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l4 (22 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l29 (8 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l21 (11 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal subunit from staphylococcus aureus - double mutation in ul3 leading to linezolid resistance (Complex from Staphylococcus aureus)
- 50s ribosomal protein l14 (13 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l20 (13 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l16 (16 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l28 (6 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l34 (5 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l25 (23 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l22 (12 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l32 (6 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l27 (10 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l18 (13 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l13 (16 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l30 (6 kDa, Protein from Staphylococcus aureus)
- 50s ribosomal protein l36 (4 kDa, Protein from Staphylococcus aureus)
Calcitonin Receptor in complex with Gs and salmon calcitonin peptide
Resolution: 2.6 Å
EM Method: Single-particle
Fitted PDBs: 7tyn
Q-score: 0.575
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Calcitonin-1 (3 kDa, Protein from Salmo salar)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Calcitonin receptor in complex with gs and salmon calcitonin peptide (Complex)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from Lama glama)
Human Amylin2 Receptor in complex with Gs and rat amylin peptide
Resolution: 2.55 Å
EM Method: Single-particle
Fitted PDBs: 7tyx
Q-score: 0.488
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ DOI: doi:10.1126/science.abm9609 Pubmed: 35324283 ]
- Amylin peptide (3 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Human amylin2 receptor in complex with gs and rat amylin peptide (Complex)
- Palmitic acid (256 Da, Ligand)
- Receptor activity-modifying protein 2 (17 kDa, Protein from Homo sapiens)
Human Amylin1 Receptor in complex with Gs and rat amylin peptide
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7tyf
Q-score: 0.631
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Human amylin1 receptor in complex with gs and rat amylin peptide (Complex)
- Receptor activity-modifying protein 1 (17 kDa, Protein from Homo sapiens)
- Amylin peptide (3 kDa, Protein from Rattus norvegicus)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Calcitonin receptor in complex with Gs and human calcitonin peptide
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7tyo
Q-score: 0.563
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Calcitonin receptor in complex with gs and human calcitonin peptide (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Calcitonin (3 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
Human Amylin3 Receptor in complex with Gs and rat amylin peptide
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7tzf
Q-score: 0.564
Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM
Science (2022) 375 pp. eabm9609-eabm9609 [ Pubmed: 35324283 DOI: doi:10.1126/science.abm9609 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Calcitonin receptor (58 kDa, Protein from Homo sapiens)
- Nanobody 35 (15 kDa, Protein from Lama glama)
- (2s)-2-{[(1r)-1-hydroxyhexadecyl]oxy}-3-{[(1r)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate (766 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Amylin peptide (3 kDa, Protein from Rattus norvegicus)
- Receptor activity-modifying protein 3 (16 kDa, Protein from Homo sapiens)
- Human amylin 3 receptor in complex with gs and rat amylin peptide (Complex)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7lci
Q-score: 0.428
Zhang X, Johnson RM, Drulyte I, Yu L, Kotecha A, Danev R, Wootten D, Sexton PM, Belousoff MJ
Structure (2021) 29 pp. 963- [ Pubmed: 33957078 DOI: doi:10.1016/j.str.2021.04.008 ]
- Glp-1:gs complex with small molecule agonist bound (pf-06882961) (Complex from Homo sapiens)
- Water (18 Da, Ligand)
- 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2s)-oxetan-2-yl]methyl}-1h-benzimidazole-6-carboxylic acid (555 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Glucagon-like peptide 1 receptor (56 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)